Shred Ingredients & Drug Interactions
by Anabolic Warfare Savage Series
What is this page for?
First and foremost: checking Shred against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Shred is a dietary supplement by Anabolic Warfare Savage Series with 9 active ingredients. Its ingredients are commonly taken for estrogen and hormone balance support, breast and cervical health, prostate health.Based on those ingredients, 1,216 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polygonum cuspidatum, Bearberry, Buchu. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Shred by Anabolic Warfare Savage Series
Ask about any prescription or over-the-counter medication and we check it for interactions with Shred by Anabolic Warfare Savage Series — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Shred by Anabolic Warfare Savage Series
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains nine ingredients. The active ones include indole-3-carbinol (a compound from cruciferous vegetables), white button mushroom extract, dandelion, juniper, buchu (a plant used in herbal medicine), 3,3' diindolylmethane (also called DIM, another plant compound), acacetin (a plant-derived flavonoid), polygonum cuspidatum (hu zhang, a traditional Chinese herb), and bearberry (also called uva ursi).
The inactive ingredients—gelatin, dicalcium phosphate, microcrystalline cellulose, magnesium stearate, and silicon dioxide—are the capsule material and fillers that hold the active compounds together.
Does it work?
Not established
We don't have established evidence in our data that these ingredients effectively treat any condition. Indole-3-carbinol, diindolylmethane, and polygonum cuspidatum have all been studied for cancers and other conditions, but the evidence we hold is rated insufficient to make a recommendation.
The same applies to the other ingredients—their roles haven't been proven in rigorous human trials, at least not in the data we have on file. That doesn't mean they don't work; it means we don't have the data to say either way.
How safe is it?
Well-documented data
Indole-3-carbinol is generally well tolerated at food levels, but supplement doses are less studied. The most common side effects are diarrhea, nausea, rash, and tremor; higher doses have caused imbalance and unsteadiness.
Dandelion is generally tolerated but can cause diarrhea, heartburn, and stomach upset, and in sensitive individuals, allergic reactions including anaphylaxis. Juniper is tolerated short-term in low doses but may irritate the kidneys with long-term use.
Buchu lacks detailed adverse-effect data but contains pulegone, a known liver toxin, so high doses or the essential oil should be avoided. Diindolylmethane commonly causes diarrhea, gas, headache, nausea, and rash; a rare serious effect (DRESS syndrome) has been reported.
Bearberry is tolerated short-term but is toxic at high doses, with effects including convulsions and delirium reported above 20 grams. For pregnancy: indole-3-carbinol, dandelion, juniper, and bearberry safety data advises against use.
Diindolylmethane is rated Likely Safe in pregnancy, but data for buchu, polygonum cuspidatum, white button mushroom extract, and acacetin isn't on file—ask your doctor or pharmacist for personalized advice. None of these ingredients have sufficient breastfeeding safety data; caution is advised across the board.
Meds to double-check
Moderate interaction found
Before taking Shred, check whether you're on blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel), estrogen or hormone replacement therapy, antidiabetes drugs, lithium, diuretics (water pills), liver-metabolizing drugs processed by CYP1A2, CYP2C19, CYP2E1, or CYP3A4 enzymes, or carbamazepine. Use the medication search tool on this page to see if your specific drugs interact with any of these ingredients.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This is a multi-ingredient product with wide-ranging interactions, especially with blood thinners, liver-metabolized drugs, estrogen therapy, diabetes medications, and lithium. If you take any prescription medications—particularly blood thinners, hormone therapy, diabetes drugs, or anticonvulsants—run them through the interaction checker on this page before you start.
Talk to your pharmacist about whether it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 7 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Shred, straight from the product label.
| Brand | Anabolic Warfare Savage Series |
|---|---|
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 16, 2022 |
| DSLD ID | 267071 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Shred by Anabolic Warfare Savage Series, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Indole-3-Carbinol | 200 mg | -- |
| White Button Mushroom extract | 300 mg | -- |
| Dandelion | 125 mg | -- |
| Juniper | 125 mg | -- |
| Buchu | 125 mg | -- |
| 3,3' Diindolylmethane | 200 mg | -- |
| Acacetin | 60 mg | -- |
| Polygonum cuspidatum | 50 mg | -- |
| Bearberry | 125 mg | -- |
Other ingredients: Gelatin, Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Shred matrix Reduce cortisol levels & water retention Suppress estrogen conversion Improve hormone health
Seals/Symbols
Made in the USA with Pride Inspected cGMP Facility Good Manufacturing Practices
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Shred by Anabolic Warfare Savage Series label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Shred by Anabolic Warfare Savage Series
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Indole-3-Carbinol
Interacts with294 drugs
Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for...
Indole-3-Carbinol monograph & interactionsWhite Button Mushroom extract
Dandelion
Interacts with457 drugs
Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for thes...
Dandelion monograph & interactionsJuniper
Interacts with162 drugs
Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its he...
Juniper monograph & interactionsBuchu
Interacts with481 drugs
Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies...
Buchu monograph & interactions3,3' Diindolylmethane
Interacts with269 drugs
Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...
3,3' Diindolylmethane monograph & interactionsAcacetin
Polygonum cuspidatum
Interacts with826 drugs
Hu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and ear...
Polygonum cuspidatum monograph & interactionsBearberry
Interacts with803 drugs
Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...
Bearberry monograph & interactionsOther (inactive) ingredients: Gelatin, Dicalcium Phosphate, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Shred by Anabolic Warfare Savage Series Drug Interactions
HelloPharmacist Interaction Report
Shred by Anabolic Warfare Savage Series contains nine ingredients, seven of which we could check for interactions with medications.
Altogether, these interactions span 1,195 individual medications. The most serious documented interaction is with blood thinners (anticoagulants and antiplatelet drugs) — indole-3-carbinol, dandelion, buchu, polygonum cuspidatum, and bearberry all carry Moderate severity warnings.
Indole-3-carbinol and dandelion can inhibit platelet clumping (aggregation); buchu and polygonum cuspidatum may also boost anticoagulant effects; bearberry's mechanism isn't specified, but the risk is the same: increased bruising and bleeding.
Read the full breakdown — every affected drug type, severity by severity
Moderate interactions also affect your liver's ability to clear certain drugs. Indole-3-carbinol, dandelion, polygonum cuspidatum, and bearberry all interact with cytochrome P450 enzymes—a group of liver proteins that metabolize many medications.
Depending on the enzyme involved and the drug, this may lower drug levels (making them less effective) or raise them (causing toxicity). Additionally, diindolylmethane, dandelion, and bearberry interact with estrogen therapy or hormone replacement; dandelion and juniper may increase low blood sugar (hypoglycemia) risk with diabetes medications; dandelion, juniper, buchu, and bearberry interact with lithium and diuretics (water pills); and polygonum cuspidatum carries a Minor warning for carbamazepine (an anti-seizure drug).
White button mushroom extract and acacetin could not be checked—we hold no interaction data for them. Use the medication search tool on this page to check your exact drugs against these ingredients.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Shred?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Shred interact with 1,216 drugs. Click any drug to see the details.
7 of the 9 ingredients in Shred interact with drugs. Each result below shows which ingredient is responsible. Polygonum cuspidatum Bearberry Buchu Dandelion Indole-3-Carbinol 3,3' Diindolylmethane Juniper
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Shred — through 1 ingredient. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Shred — through 2 ingredients. Tap an ingredient for the detail:
BearberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Ado-trastuzumab Emtansine interactionPolygonum CuspidatumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Polygonum Cuspidatum + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Shred — through 1 ingredient. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Shred — through 1 ingredient. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Shred — through 4 ingredients. Tap an ingredient for the detail:
BuchuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu may have antiplatelet effects.
Read the full Buchu + Abciximab interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Abciximab interactionDandelionAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
Read the full Dandelion + Abciximab interactionPolygonum CuspidatumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Polygonum Cuspidatum + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Shred — through 2 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Polygonum Cuspidatum + Abemaciclib interactionBearberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Shred — through 3 ingredients. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Abiraterone interactionBearberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Abiraterone interactionPolygonum CuspidatumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Polygonum Cuspidatum + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Shred — through 3 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Polygonum Cuspidatum + Abiraterone Acetate interactionBearberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Abiraterone Acetate interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Shred — through 5 ingredients. Tap an ingredient for the detail:
BuchuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu may have antiplatelet effects.
Read the full Buchu + Abrocitinib interactionBearberryCytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
Read the full Bearberry + Abrocitinib interactionPolygonum CuspidatumAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Polygonum Cuspidatum + Abrocitinib interactionDandelionAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
Read the full Dandelion + Abrocitinib interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Shred — through 2 ingredients. Tap an ingredient for the detail:
BearberryCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Acalabrutinib interactionPolygonum CuspidatumCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Polygonum Cuspidatum + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Shred — through 3 ingredients. Tap an ingredient for the detail:
DandelionAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Read the full Dandelion + Acarbose interactionJuniperAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Read the full Juniper + Acarbose interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Shred — through 1 ingredient. Tap an ingredient for the detail:
BuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Shred — through 4 ingredients. Tap an ingredient for the detail:
BuchuAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu may have antiplatelet effects.
Read the full Buchu + Acenocoumarol interactionPolygonum CuspidatumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Polygonum Cuspidatum + Acenocoumarol interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Acenocoumarol interactionDandelionAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
Read the full Dandelion + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
DandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen interactionPolygonum CuspidatumCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Polygonum Cuspidatum + Acetaminophen interactionBearberryGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Polygonum Cuspidatum + Acetaminophen, Aspirin interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Aspirin interactionIndole-3-carbinolAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Indole-3-carbinol + Acetaminophen, Aspirin interactionBuchuHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Aspirin interactionBearberryGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Aspirin interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
BearberryGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Aspirin, Caffeine interactionDandelionCytochrome P450 1a2 (cyp1a2) Substrates, Glucuronidated Drugs +1 Moderate
Interaction Summary
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion + Acetaminophen, Aspirin, Caffeine interactionBuchuHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Aspirin, Caffeine interactionPolygonum CuspidatumAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Polygonum Cuspidatum + Acetaminophen, Aspirin, Caffeine interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Aspirin, Caffeine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
DandelionCytochrome P450 1a2 (cyp1a2) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionPolygonum CuspidatumCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Polygonum Cuspidatum + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionBearberryGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Brompheniramine, Phenylpropanolamine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Read the full Polygonum Cuspidatum + Acetaminophen, Butalbital interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Butalbital interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital interactionBearberryGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Butalbital interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
BearberryGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Butalbital, Caffeine interactionDandelionCytochrome P450 1a2 (cyp1a2) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion + Acetaminophen, Butalbital, Caffeine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital, Caffeine interactionPolygonum CuspidatumCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Read the full Polygonum Cuspidatum + Acetaminophen, Butalbital, Caffeine interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital, Caffeine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
DandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Butalbital, Caffeine, Codeine interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital, Caffeine, Codeine interactionPolygonum CuspidatumCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Polygonum Cuspidatum + Acetaminophen, Butalbital, Caffeine, Codeine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital, Caffeine, Codeine interactionBearberryGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Butalbital, Caffeine, Codeine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Read the full Polygonum Cuspidatum + Acetaminophen, Butalbital, Codeine interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital, Codeine interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Butalbital, Codeine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital, Codeine interactionBearberryGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Butalbital, Codeine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
BearberryGlucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Butalbital, Codeine Phosphate interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Butalbital, Codeine Phosphate interactionPolygonum CuspidatumCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Read the full Polygonum Cuspidatum + Acetaminophen, Butalbital, Codeine Phosphate interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Butalbital, Codeine Phosphate interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Butalbital, Codeine Phosphate interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionPolygonum CuspidatumCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Polygonum Cuspidatum + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionBearberryCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Polygonum Cuspidatum + Acetaminophen, Caffeine, Codeine interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Codeine interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Caffeine, Codeine interactionBearberryGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Caffeine, Codeine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Codeine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
BearberryCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Codeine, Salicylamide interactionPolygonum CuspidatumCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Read the full Polygonum Cuspidatum + Acetaminophen, Caffeine, Codeine, Salicylamide interactionDandelionCytochrome P450 1a2 (cyp1a2) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion + Acetaminophen, Caffeine, Codeine, Salicylamide interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Codeine, Salicylamide interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Indole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Dihydrocodeine interactionPolygonum CuspidatumCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Polygonum Cuspidatum + Acetaminophen, Caffeine, Dihydrocodeine interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Caffeine, Dihydrocodeine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Dihydrocodeine interactionBearberryCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Acetaminophen, Caffeine, Dihydrocodeine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Read the full Polygonum Cuspidatum + Acetaminophen, Caffeine, Isometheptene interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Caffeine, Isometheptene interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Isometheptene interactionBearberryGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Caffeine, Isometheptene interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Isometheptene interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Shred — through 7 ingredients. Tap an ingredient for the detail:
BearberryCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Acetaminophen, Caffeine, Pyrilamine interactionDandelionCytochrome P450 1a2 (cyp1a2) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Read the full Dandelion + Acetaminophen, Caffeine, Pyrilamine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Caffeine, Pyrilamine interactionPolygonum CuspidatumCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Polygonum Cuspidatum + Acetaminophen, Caffeine, Pyrilamine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Caffeine, Pyrilamine interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Caffeine, Pyrilamine interactionJuniperDiuretic Drugs Minor
Interaction Summary
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Read the full Juniper + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Read the full Polygonum Cuspidatum + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionBearberryCytochrome P450 3a4 (cyp3a4) Substrates, Glucuronidated Drugs Moderate
Interaction Summary
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
Read the full Bearberry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Shred — through 6 ingredients. Tap an ingredient for the detail:
Polygonum CuspidatumCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Read the full Polygonum Cuspidatum + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionDandelionGlucuronidated Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
Read the full Dandelion + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionIndole-3-carbinolCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Read the full Indole-3-carbinol + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBearberryGlucuronidated Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
Read the full Bearberry + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionBuchuHepatotoxic Drugs Moderate
Interaction Summary
Buchu contains pulegone, a known hepatotoxin.
Read the full Buchu + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interaction3,3' DiindolylmethaneCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
Read the full 3,3' Diindolylmethane + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Shred with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Polygonum cuspidatum
Anticoagulant/Antiplatelet Drugs
Theoretically, hu zhang might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Hu zhang contains the constituent resveratrol. Resveratrol seems to have antiplatelet effects.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, hu zhang might increase levels of drugs metabolized by CYP1A2.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP1A2 enzyme. This interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, hu zhang might increase levels of drugs metabolized by CYP2C19.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2C19 enzyme. This interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, hu zhang might increase levels of drugs metabolized by CYP2E1.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP2E1 enzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, hu zhang might increase levels of drugs metabolized by CYP3A4.
Hu zhang contains the constituent resveratrol. In vitro research shows that resveratrol might inhibit the CYP3A4 enzyme. However, a clinical study in adults with NAFLD found that adding resveratrol 3000 mg daily for 8 weeks did not necessitate dose adjustments to any established medications metabolized by CYP3A4.
Estrogens
Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that hu zhang might have estrogenic activity.
Carbamazepine (Tegretol)
Theoretically, hu zhang might increase the effects and adverse effects of carbamazepine.
In animals, blood and tissue levels of carbamazepine were increased when given in combination with hu zhang. It is thought that increased levels of carbamazepine are due to cytochrome P450 3A4 (CYP3A4) inhibition. This interaction has not been reported in humans.
Bearberry
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.
Glucuronidated Drugs
Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.
Lithium
Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.
Urinary Acidifying Agents
Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.
P-Glycoprotein Substrates
Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.
Buchu
Anticoagulant/Antiplatelet Drugs
Buchu may have antiplatelet effects. Theoretically, buchu may enhance the effects of anticoagulant or antiplatelet drugs and increase the risk of bleeding in some patients. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Hepatotoxic Drugs
Buchu contains pulegone, a known hepatotoxin. There is some concern that buchu may adversely affect the liver, especially when the leaf is used in large doses or the oil is ingested. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo)
Lithium
Buchu is thought to have diuretic properties. Theoretically, buchu might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Dandelion
Anticoagulant/Antiplatelet Drugs
Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.
Antidiabetes Drugs
Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.
Glucuronidated Drugs
Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.
Lithium
Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.
Potassium-Sparing Diuretics
Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.
Quinolone Antibiotics
Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.
Indole-3-Carbinol
Anticoagulant/Antiplatelet Drugs
Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.
Estrogens
Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.
3,3' Diindolylmethane
Diuretic Drugs
Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.
Estrogens
Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.
Juniper
Antidiabetes Drugs
Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.
Diuretic Drugs
Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.
Lithium
Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.
Brand information
Manufacturer and brand details for Shred, from the product label.
Anabolic Warfare Savage Series
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The Full Monographs Behind Shred’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Indole-3-carbinol
Interacts with 294 drugsIndole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...
Read the full Indole-3-carbinol monograph → Herb & supplement monographDandelion
Interacts with 457 drugsDandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...
Read the full Dandelion monograph → Herb & supplement monographJuniper
Interacts with 162 drugsJuniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...
Read the full Juniper monograph → Herb & supplement monographBuchu
Interacts with 481 drugsBuchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies are lacking, so its benefits are largely...
Read the full Buchu monograph → Herb & supplement monographDiindolylmethane
Interacts with 269 drugsDiindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...
Read the full Diindolylmethane monograph → Herb & supplement monographHu Zhang
Interacts with 826 drugsHu Zhang (Japanese knotweed root) is a traditional Chinese herb that is one of the richest natural sources of resveratrol and emodin. Some lab and early human research looks interesting for...
Read the full Hu Zhang monograph → Herb & supplement monographUva Ursi
Interacts with 803 drugsUva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...
Read the full Uva Ursi monograph →Sources & How We Checked
Shred's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 87 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Indole-3-carbinol 9 references
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- He YH, Friesen MD, Ruch RJ, Schut HA. Indole-3-carbinol as a chemopreventive agent in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis: inhibition of PhIP-DNA adduct formation, acceleration of PhIP metabolism, and induction of cytoch
- Kim, Y. S. and Milner, J. A. Targets for indole-3-carbinol in cancer prevention. J.Nutr.Biochem. 2005;16(2):65-73. PubMed
- Anon. Indole-3-carbinol. Monograph. Alternative Medicine Review 2005;10(4):337-42.
- McAlindon TE, Gulin J, Chen T, et al. Indole-3-carbinol in women with SLE: effect on estrogen metabolism and disease activity. Lupus 2001;10:779-83. PubMed
- Reed GA, Peterson KS, Smith HJ, et al. A phase I study of indole-3-carbinol in women: tolerability and effects. Cancer Epidemiol Biomarkers Prev 2005;14:1953-60. PubMed
- Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591-5.
- Paliwal P, Chauhan G, Gautam D, Dash D, Patne SCU, Krishnamurthy S. Indole-3-carbinol improves neurobehavioral symptoms in a cerebral ischemic stroke model. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(6):613-625. PubMed
Dandelion 27 references
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- Williams CA, Goldstone F, Greenham J. Flavonoids, cinnamic acids and coumarins from the different tissues and medicinal preparations of Taraxacum officinale. Phytochemistry 1996;42:121-7. PubMed
- Hussain Z, Waheed A, Qureshi RA, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res 2004;18:73-7. PubMed
- Racz-Kotilla E, Racz G, Solomon A. The action of Taraxacum officinale extracts on the body weight and diuresis of laboratory animals. Planta Med 1974;26:212-7. PubMed
- Zhu M, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci 1999;88:632-4. PubMed
- Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
- Chivato T, Juan F, Montoro A, Laguna R. Anaphylaxis induced by ingestion of a pollen compound. J Investig Allergol Clin Immunol 1996;6:208-9.
- Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
- Lovell CR, Rowan M. Dandelion dermatitis. Contact Dermatitis 1991;25:185-8. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Martín-Muñoz MF, Bartolome B, Caminoa M, et al. Bee pollen: a dangerous food for allergic children. Identification of responsible allergens. Allergol Immunopathol (Madr) 2010;38:263-5. PubMed
- Neef H, Cilli F, Declerck PJ, et al. Platelet anti-aggregating activity of Taraxacum officinale Weber. Phytotherapy Research 1996;10:s138-s140.
- Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
- Posadzki, P., Watson, L. K., and Ernst, E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med 2013;13(1):7-12. PubMed
- Wakelin, S. H., Marren, P., Young, E., and Shaw, S. Compositae sensitivity and chronic hand dermatitis in a seven-year-old boy. Br J Dermatol 1997;137(2):289-291. PubMed
- Ingber, A. Seasonal allergic contact dermatitis from Taraxacum officinale (dandelion) in an Israeli florist. Contact Dermatitis 2000;43(1):49.
- Rodriguez, B., Rodriguez, A., de Barrio, M., Tornero, P., and Baeza, M. L. Asthma induced by canary food mix. Allergy Asthma Proc. 2003;24(4):265-268.
- Syhaieva, I. A. [Efficiency of specific immunotherapy in treatment of patients with seasonal allergic rhinitis]. Lik.Sprava. 2006;(1-2):51-53.
- Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. PubMed
- Goksu, E., Eken, C., Karadeniz, O., and Kucukyilmaz, O. First report of hypoglycemia secondary to dandelion (Taraxacum officinale) ingestion. Am J Emerg.Med 2010;28(1):111-112. PubMed
- Fernandez-Gonzalez, D., Gonzalez-Parrado, Z., Vega-Maray, A. M., Valencia-Barrera, R. M., Camazon-Izquierdo, B., De, Nuntiis P., and Mandrioli, P. Platanus pollen allergen, Pla a 1: quantification in the atmosphere and influence on a sensitizing populati
- Liang, K. L., Su, M. C., Shiao, J. Y., Wu, S. H., Li, Y. H., and Jiang, R. S. Role of pollen allergy in Taiwanese patients with allergic rhinitis. J Formos.Med Assoc. 2010;109(12):879-885. PubMed
- Yang, Y., Zhao, Y., Wang, C. S., Wang, X. D., and Zhang, L. [Prevalence of sensitization to aeroallergens in 10 030 patients with allergic rhinitis]. Zhonghua Er.Bi Yan.Hou Tou.Jing.Wai Ke Za Zhi 2011;46(11):914-920.
- Davies, M. G. and Kersey, P. J. Contact allergy to yarrow and dandelion. Contact Dermatitis 1986;14(4):256-257. PubMed
- Collins JM and Miller DR. Dandelion green bezoar following antrectomy and vagotomy - case report. J Kansas Med Soc 1966;67(6):303-304.
- Moriarty B, Pinney JH, Owen-Casey MP, Rustin MH, Deroide F, Laing C, Davenport A. Digital necrosis from dandelion tea. Br J Dermatol. 2013 Jul;169(1):227-30. PubMed
- Onal S, Timur S, Okutucu B, Zihnioglu F. Inhibition of alphaglucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep Biochem Biotechnol 2005;35:29-36.
Juniper 7 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Robbers JE, Tyler VE. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. New York, NY: The Haworth Herbal Press, 1999.
- Sanchez de Medina F, Gamez MJ, Jimenez I, et al. Hypoglycemic activity of juniper "berries." Planta Med 1994;60:197-200. PubMed
- Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990;33:462-4. PubMed
- Tammaro A, Adebanjo GAR, Chello C, et al. Bullous dermatitis caused by common juniper. Contact Dermatitis. 2020. PubMed
Buchu 3 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Moolla A, Viljoen AM. 'Buchu' - Agathosma betulina and Agathosma crenulata (Retaceae): a review. J Ethnopharmacol 2008;119(3):413-9.
Diindolylmethane 14 references
- Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
- Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
- Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
- Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
- Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
- Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
- Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
- Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
- Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
- Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
- Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
- Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
- Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
- Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed
Hu Zhang 19 references
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- Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
- Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
- Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
- Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
- Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
- Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg Med Chem Lett 2001;11:1839-42. PubMed
- Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
- Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
- Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
- Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
- Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
- Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
- Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
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Uva Ursi 8 references
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- Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
- Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
- de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
- Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
- Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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