Shred Research Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Shred Research against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Shred Research is a dietary supplement by Sarms Pharm (SP) with 3 active ingredients. Its ingredients are commonly taken for muscle building, strength gains, fat loss / body recomposition.Based on those ingredients, 612 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ostarine MK-2866, Andarine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Shred Research by Sarms Pharm (SP)
Ask about any prescription or over-the-counter medication and we check it for interactions with Shred Research by Sarms Pharm (SP) — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Shred Research by Sarms Pharm (SP)
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Shred Research contains three active ingredients, each a selective androgen receptor modulator (SARM) or related research compound: Andarine (S-4), Stenabolic SR-9009, and Ostarine MK-2866. These are investigational drugs designed to affect how your body builds and uses muscle, but none are approved by the FDA and none are legal to sell as dietary supplements.
The product contains no inactive ingredients listed.
Does it work?
Couldn't assess
The evidence supporting these ingredients is not established. For Andarine, Stenabolic, and Ostarine, the data we hold shows insufficient reliable evidence to rate their effectiveness for athletic performance, weight management, muscle wasting, or any other claimed use.
These are research compounds without proven benefit in humans.
How safe is it?
Well-documented data
This product carries serious safety warnings. Andarine and Ostarine are unapproved investigational drugs with known risks: both may damage the liver, increase markers of liver injury, and raise the risk of heart attack or stroke according to FDA warnings.
Ostarine has caused abdominal pain, nausea, diarrhea, and in clinical trials, increases in liver enzymes in a meaningful portion of users. Stenabolic is an untested research chemical with no human safety data at all.
None of these ingredients should be used during pregnancy—Andarine and Ostarine affect hormone pathways, and Stenabolic is rated possibly unsafe with no safety information. Breastfeeding is also contraindicated for all three due to lack of safety data.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take androgens (androgenic drugs), hepatotoxic medications, drugs that induce or inhibit CYP3A4 metabolism, probenecid, rifampin, or substrates of CYP2C9. The moderate-severity interactions with androgens and liver-toxic drugs are the most serious concerns.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Shred Research is not a legal supplement; it contains three unapproved research compounds with significant gaps in human safety data and documented risks to your liver and heart. The evidence supporting their effectiveness is insufficient.
If you're considering this product, talk with your doctor or pharmacist first—do not start it without personalized medical guidance, and be honest with them about any medications you take, since the interactions are substantial.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Shred Research, straight from the product label.
| Brand | Sarms Pharm (SP) |
|---|---|
| Net contents | 90 Cap(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 242059 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | No Claim |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Shred Research by Sarms Pharm (SP), sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Andarine | 50 mg | -- |
| Stenabolic SR-9009 | 30 mg | -- |
| Ostarine MK-2866 | 30 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Research Product
90 Caps / 30 mg / 30 mg / 50 mg per 3 Caps
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Shred Research by Sarms Pharm (SP) label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Shred Research by Sarms Pharm (SP)
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size0 Not Present Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Andarine
Interacts with9 drugs
Andarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It i...
Andarine monograph & interactionsStenabolic SR-9009
No knowninteractions
Stenabolic (also called SR9009) is an experimental research chemical, not a true dietary supplement, herb, or approved drug. It is sold online for fat...
Stenabolic SR-9009 monograph & interactionsOstarine MK-2866
Interacts with611 drugs
Ostarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not a true di...
Ostarine MK-2866 monograph & interactionsShred Research by Sarms Pharm (SP) Drug Interactions
HelloPharmacist Interaction Report
Shred Research by Sarms Pharm contains three active ingredients—Andarine, Stenabolic SR-9009, and Ostarine MK-2866—two of which carry documented interactions with medications.
The most serious concern is Andarine's moderate-severity interaction with androgens (other androgenic drugs), which may increase the risk of androgenic side effects including masculinization, virilization, acne, hair loss, increased libido, and aggression.
Read the full breakdown — every affected drug type, severity by severity
Ostarine interacts with several drug types. It may increase the risk of liver damage (hepatotoxicity) when used alongside hepatotoxic drugs.
It can also be affected by CYP3A4 inducers (such as rifampin), which may reduce ostarine's effectiveness, and by probenecid, which may raise ostarine levels and increase both its effects and side effects. CYP3A4 inhibitors and CYP2C9 substrates carry minor-severity interactions with ostarine, though clinical significance is limited.
Stenabolic SR-9009 has no documented interactions in our data. Altogether, these interactions span 613 individual medications.
Because this product contains unapproved research compounds with significant safety gaps, you should discuss it with your doctor or pharmacist before considering use, and run your exact medications through the checker below if you do.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Shred Research?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Shred Research interact with 612 drugs. Click any drug to see the details.
2 of the 3 ingredients in Shred Research interact with drugs. Each result below shows which ingredient is responsible. Ostarine MK-2866 Andarine
AprocitentanTryvio
How Aprocitentan interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inhibitors, Cytochrome P450 3a4 (cyp3a4) Inducers +1 Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inhibitors could increase the effects and adverse effects of ostarine, although this is unlikely to be clinically significant.
Read the full Ostarine Mk-2866 + Aprocitentan interactionArmodafinilNuvigil
How Armodafinil interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Armodafinil interactionAsparaginase Erwinia Chrysanthemi (recombinant)-rywnRylaze
How Asparaginase Erwinia Chrysanthemi (recombinant)-rywn interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Asparaginase Erwinia Chrysanthemi (recombinant)-rywn interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Aspirin, Codeine Phosphate, Phenobarbital interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Atorvastatin Calcium interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Atropine, Phenobarbital interactionAvacopanTavneos
How Avacopan interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inhibitors, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inhibitors could increase the effects and adverse effects of ostarine, although this is unlikely to be clinically significant.
Read the full Ostarine Mk-2866 + Avacopan interactionAzamuneImmunoprin
How Azamune interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Azathioprine interactionBaricitinibOlumiant
How Baricitinib interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Baricitinib interactionBelinostatBeleodaq
How Belinostat interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Belinostat interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Belladonna Extract, Phenobarbital interactionBelladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Belladonna, Ergotamine, Phenobarbital interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Belladonna, Phenobarbital interactionBellafoline, PhenobarbitalBelladenal, Belladenal-S
How Bellafoline, Phenobarbital interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Read the full Ostarine Mk-2866 + Bellafoline, Phenobarbital interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Benzhydrocodone, Acetaminophen interactionBimekizumab-bkzxBimzelx
How Bimekizumab-bkzx interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Bimekizumab-bkzx interactionBinimetinibMektovi
How Binimetinib interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Binimetinib interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Cytochrome P450 3a4 (cyp3a4) Inhibitors, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of ostarine with CYP3A4 inhibitors could increase the effects and adverse effects of ostarine, although this is unlikely to be clinically significant.
Read the full Ostarine Mk-2866 + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionBortezomibVelcade
How Bortezomib interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Bortezomib interactionBosentanTracleer
How Bosentan interacts with Shred Research — through 1 ingredient. Tap an ingredient for the detail:
Ostarine Mk-2866Hepatotoxic Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Read the full Ostarine Mk-2866 + Bosentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Shred Research with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Ostarine MK-2866
Cytochrome P450 3A4 (Cyp3A4) Inducers
Theoretically, concomitant use of ostarine with CYP3A4 inducers could decrease the clinical effects of ostarine.
Ostarine is partially metabolized by CYP3A4. Clinical research shows that taking rifampin, a potent inducer of CYP3A4, reduces the maximum plasma concentration of ostarine by 23% and the area under the curve by 43%.
Hepatotoxic Drugs
Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.
Some clinical research shows that ostarine can increase alanine aminotransferase, a marker of liver damage, in some patients. Additionally, the U.S. Food and Drug Administration warns that supplements containing SARMs, such as ostarine, have been associated with reports of liver toxicity and there are at least two reports of drug-induced liver injury attributed to the use of ostarine.
Probenecid (Benemid)
Theoretically, concomitant use of ostarine with probenecid could increase the effects and adverse effects of ostarine.
Clinical research shows that probenecid increases ostarine levels and slows the clearance of ostarine, likely via inhibition of UDP-glucuronosyltransferase (UGT). Ostarine is partially metabolized by UGT.
Rifampin (Rifadin)
Theoretically, concomitant use of ostarine with rifampin could decrease the clinical effects of ostarine.
Clinical research shows that taking rifampin with ostarine reduces the maximum plasma concentration of ostarine by 23% and the area under the curve by 43%. Ostarine is partially metabolized by cytochrome P450 3A4 (CYP3A4), and rifampin is a potent CYP3A4 inducer.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, ostarine might increase levels of drugs metabolized by CYP2C9, although clinical research suggests this is not clinically relevant.
Although in vitro research suggests that ostarine inhibits CYP2C9, more robust clinical research shows that ostarine does not significantly affect CYP2C9.
Cytochrome P450 3A4 (Cyp3A4) Inhibitors
Theoretically, concomitant use of ostarine with CYP3A4 inhibitors could increase the effects and adverse effects of ostarine, although this is unlikely to be clinically significant.
Ostarine is partially metabolized by CYP3A4. However, clinical research shows that taking itraconazole, a potent inhibitor of CYP3A4, had minimal effects on the levels of ostarine in the body.
Andarine
Androgens
Due to its androgenic properties, Andarine (S-4) may theoretically interact with other androgenic drugs, potentially increasing the risk of side effects associated with androgenic activity (source: https://pubmed.ncbi.nlm.nih.gov/12604714/). These side effects can include masculinization, virilization, acne, hair loss, increased libido, aggression, mood changes, and liver toxicity.
Brand information
Manufacturer and brand details for Shred Research, from the product label.
Shred Research by Sarms Pharm (SP): Common Questions
Does Shred Research by Sarms Pharm (SP) interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this product legal to buy?
Can I take this if I'm pregnant or breastfeeding?
What are the main side effects I should know about?
Does this product actually work for muscle building or fat loss?
What happens if these ingredients affect my liver?
Should I have my liver checked if I take this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Shred Research is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Shred Research’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Andarine
Interacts with 9 drugsAndarine (S-4) is a synthetic selective androgen receptor modulator (SARM) that is not approved by the FDA for human use and is banned in sports. It is not a legal dietary supplement ingredi...
Read the full Andarine monograph → Herb & supplement monographStenabolic
Stenabolic (also called SR9009) is an experimental research chemical, not a true dietary supplement, herb, or approved drug. It is sold online for fat loss and endurance, but it has never be...
Read the full Stenabolic monograph → Herb & supplement monographOstarine
Interacts with 611 drugsOstarine (also called MK-2866 or enobosarm) is an experimental, unapproved drug known as a SARM (selective androgen receptor modulator), not a true dietary supplement. It is not approved by...
Read the full Ostarine monograph →Sources & How We Checked
Shred Research's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Andarine 1 reference
- FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
Stenabolic 1 reference
- What Should Tested Athletes Know About GW1516? Education, Spirit of Sport. U.S. Anti-Doping Agency (USADA). September 24, 2019. Available at: https://www.usada.org/spirit-of-sport/education/what-should-athletes-know-gw1516/
Ostarine 10 references
- Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
- Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
- Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
- Dobs AS, Boccia RV, Croot CC, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14(4):335-45. PubMed
- Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II tri
- Coss CC, Jones A, Dalton JT. Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024 (enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin. Invest New Drugs 2016;34(4):458-67. PubMed
- FDA. FDA Warns against using SARMs in body building products. October 2017. Available at: https://www.fda.gov/newsevents/newsroom/fdainbrief/ucm583021.htm.
- Bedi H, Hammond C, Sanders D, Yang HM, Yoshida EM. Drug-induced liver injury from enobosarm (ostarine), a selective androgen receptor modulator. ACG Case Rep J 2021;8(1):e00518. PubMed
- Kintz P, Gheddar L, Paradis C, et al. Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- d) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516
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