Interactions on record — worth a quick check against your medications. Based on 7 of 10 ingredients. Check your meds →
Dietary supplement

ShredOne Ingredients & Drug Interactions

by NutraOne

ShredOne label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ShredOne against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ShredOne is a dietary supplement by NutraOne with 10 active ingredients. Its ingredients are commonly taken for lowering estrogen levels, post-cycle therapy after steroid or prohormone use, reducing gynecomastia ('gyno').Based on those ingredients, 1,217 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Resveratrol, Uva Ursi, Buchu. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ShredOne by NutraOne

Ask about any prescription or over-the-counter medication and we check it for interactions with ShredOne by NutraOne — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ShredOne by NutraOne

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

ShredOne contains 10 active ingredients. Arimistane is an aromatase inhibitor (a hormone-altering compound).

Indole-3-carbinol is a plant compound from cruciferous vegetables. Buchu, juniper berry, uva ursi, dandelion, and resveratrol are botanical extracts.

DIM, acacetin, and white button mushroom extract round out the formula. The product also contains inactive ingredients (maltodextrin, magnesium stearate, gelatin, titanium dioxide, and FD&C Blue #1) as binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: fat loss and estrogen reduction support.
  • We looked for evidence on: Obesity, body composition, hormonal balance, weight management.
  • The strongest evidence on file: Resveratrol is rated "Possibly Effective" for Obesity (Natural Medicines).
  • Also on file: Arimistane is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence for ShredOne's ingredients is sparse. Resveratrol is possibly effective for obesity and allergic rhinitis (hay fever), though it appears possibly ineffective for cardiovascular disease and high cholesterol.

For nearly every other use claimed by the product's ingredients—muscle strength, athletic performance, sexual function, urinary tract infections, joint pain, and others—we hold insufficient reliable evidence to rate their effectiveness. The data we have does not support claims that uva ursi works for urinary tract infections; it's rated possibly ineffective for that purpose.

The evidence, ingredient by ingredient Arimistane Indole-3-carbinol Buchu Juniper Uva Ursi Dandelion Resveratrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Several ingredients warrant caution or avoidance. Arimistane is a hormone-altering drug with little safety data and regulators warn against aromatase inhibitor supplements; do not use during pregnancy or breastfeeding.

Indole-3-carbinol, buchu, juniper berry, and uva ursi should be avoided in pregnancy due to potential uterine effects or lack of safety data, and breastfeeding is not recommended with any of them. Dandelion has limited pregnancy/breastfeeding data; caution is advised while breastfeeding.

Resveratrol is likely safe in pregnancy but should be avoided while breastfeeding. Common mild side effects from individual ingredients include diarrhea, nausea, and stomach upset.

Uva ursi at very high doses (30 grams or more) may be fatal; the product should not be used long-term. Indole-3-carbinol at higher doses has been associated with imbalance and tremor.

Side effects, ingredient by ingredient Arimistane Indole-3-carbinol Buchu Juniper Uva Ursi Dandelion Resveratrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Buchu, Resveratrol, Uva Ursi, Dandelion, Juniper, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,218 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking ShredOne, double-check with your doctor or pharmacist if you take blood thinners (anticoagulants or antiplatelets like warfarin or aspirin), diabetes medications, lithium, or any drug metabolized by your liver's cytochrome P450 system (including many antidepressants, heart drugs, and others). The product may also interfere with estrogen therapy and fluoroquinolone antibiotics.

Most serious interactions are Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

ShredOne is marketed for fat loss and body composition, but the evidence supporting its ingredients is weak to absent. The product carries multiple moderate interactions with common medications—especially blood thinners, diabetes drugs, and lithium—and contains a hormone-altering ingredient (Arimistane) that regulators warn against.

If you take any prescription medication or have plans to become pregnant or breastfeed, talk with your doctor or pharmacist before starting this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ShredOne, straight from the product label.

Brand NutraOne
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 172508
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ShredOne by NutraOne, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
IngredientAmount% DV
Androst-3,5-Dien-7,17-Dione50 mg--
Indole-3-Carbinol200 mg--
Buchu125 mg--
Juniper berry extract125 mg--
DIM200 mg--
Acacetin60 mg--
White Button Mushroom extract300 mg--
Uva Ursi125 mg--
Dandelion125 mg--
Resveratrol50 mg--

Other ingredients: Maltodextrin, Magnesium Stearate, Gelatin, Titanium Dioxide, FD&C Blue #1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

General Statements

Shred matrix Shred fat Insane definition Block estrogen

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ShredOne by NutraOne label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ShredOne label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ShredOne by NutraOne

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Androst-3,5-Dien-7,17-Dione

Interacts with
4 drugs
50 mg per serving

Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone,...

Androst-3,5-Dien-7,17-Dione monograph & interactions

Indole-3-Carbinol

Interacts with
294 drugs
200 mg per serving

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for...

Indole-3-Carbinol monograph & interactions

Buchu

Interacts with
481 drugs
125 mg per serving

Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies...

Buchu monograph & interactions

Juniper berry extract

Interacts with
162 drugs
125 mg per serving

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its he...

Juniper berry extract monograph & interactions

DIM

200 mg per serving

Acacetin

60 mg per serving

White Button Mushroom extract

300 mg per serving

Uva Ursi

Interacts with
803 drugs
125 mg per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva Ursi monograph & interactions

Dandelion

Interacts with
457 drugs
125 mg per serving

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for thes...

Dandelion monograph & interactions

Resveratrol

Interacts with
822 drugs
50 mg per serving Form: Polygonum cuspidatum

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

Resveratrol monograph & interactions

Other (inactive) ingredients: Maltodextrin, Magnesium Stearate, Gelatin, Titanium Dioxide, FD&C Blue #1. These complete the product’s ingredient list but are not active constituents.

Interaction report

ShredOne by NutraOne Drug Interactions

Want to check YOUR meds against ShredOne?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,217Drugs
1,119 Moderate 98 Minor

Ingredients driving the most interactions

Resveratrol 822
Uva Ursi 803
Buchu 481
Dandelion 457
Indole-3-Carbinol 294

Individual Drug Interactions

The ingredients in ShredOne interact with 1,217 drugs. Click any drug to see the details.

7 of the 10 ingredients in ShredOne interact with drugs. Each result below shows which ingredient is responsible. Resveratrol Uva Ursi Buchu Dandelion Indole-3-Carbinol Juniper berry extract Androst-3,5-Dien-7,17-Dione

Each ingredient & the kinds of drugs it affects

For each ingredient in ShredOne with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
Resveratrol full monograph & interactions

Uva Ursi6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva Ursi full monograph & interactions

Buchu3 drug types · 481 drugs

Anticoagulant/Antiplatelet Drugs

Buchu may have antiplatelet effects. Theoretically, buchu may enhance the effects of anticoagulant or antiplatelet drugs and increase the risk of bleeding in some patients. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Buchu contains pulegone, a known hepatotoxin. There is some concern that buchu may adversely affect the liver, especially when the leaf is used in large doses or the oil is ingested. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of liver damage. Some of these drugs include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo)

Likelihood Possible Evidence D
Lithium

Buchu is thought to have diuretic properties. Theoretically, buchu might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Buchu full monograph & interactions

Dandelion7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion full monograph & interactions

Indole-3-Carbinol3 drug types · 294 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, indole-3-carbinol might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro research shows that indole-3-carbinol inhibits platelet aggregation.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, indole-3-carbinol might increase the metabolism of CYP1A2 substrates and lower serum concentrations.
Animal research shows that indole-3-carbinol induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Estrogens

Indole-3-carbinol might interfere with the effects of estrogen therapy.
Preliminary clinical and in vitro evidence shows that indole-3-carbinol has antiestrogenic activity.

Likelihood Possible Evidence D
Indole-3-Carbinol full monograph & interactions

Juniper berry extract3 drug types · 162 drugs

Antidiabetes Drugs

Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.
Animal research shows that juniper berry can lower blood glucose.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, juniper berry might increase the risk of adverse effects from diuretic drugs.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Lithium

Theoretically, juniper berry might reduce lithium excretion and increase serum levels of lithium.
Juniper berry is thought to have mild diuretic effects.

Likelihood Possible Evidence D
Juniper berry extract full monograph & interactions

Androst-3,5-Dien-7,17-Dione1 drug type · 4 drugs

Aromatase Inhibitors

It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors. This interaction could potentially increase the risk of side effects associated with low estrogen levels or from additive side effects, such as an increased risk of liver toxicity. It is recommended to consult with a healthcare provider before combining Arimistane with other aromatase inhibitors to assess the potential risks and benefits.

Likelihood Probable Evidence C
Androst-3,5-Dien-7,17-Dione full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ShredOne, from the product label.

NutraOne

See all NutraOne products
Name
NutraOne Nutrition
Pharmacist Counseling Corner

ShredOne by NutraOne: Common Questions

Does ShredOne by NutraOne interact with any medications?
Yes. Based on its ingredients, ShredOne has a known interaction with 1,217 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ShredOne contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take ShredOne if I'm pregnant or trying to get pregnant?
No. Arimistane is rated possibly unsafe in pregnancy and should be avoided—lowering estrogen during pregnancy could be harmful. Indole-3-carbinol, buchu, juniper berry, and uva ursi are also rated unsafe or likely unsafe for pregnancy. Talk with your doctor or pharmacist before taking this product if you're pregnant or planning to be.
Is it safe to breastfeed while taking ShredOne?
No. Most of the active ingredients in this product—including arimistane, indole-3-carbinol, buchu, juniper berry, and uva ursi—either have no safety data or are not recommended while breastfeeding. Only resveratrol carries a likely safe rating during lactation. Discuss this with your doctor or pharmacist before use.
What are the most common side effects?
The most common mild effects reported from ingredients in this product are diarrhea, nausea, stomach discomfort, and heartburn. Indole-3-carbinol at higher doses has been linked to imbalance, tremor, and unsteadiness. Uva ursi at very high doses can cause serious effects; this product should not be used long-term.
Does ShredOne actually help you lose weight?
Only resveratrol, one ingredient in the formula, is rated possibly effective for obesity. For the other ingredients—arimistane, indole-3-carbinol, buchu, juniper berry, uva ursi, dandelion, DIM, acacetin, and white button mushroom extract—we hold insufficient evidence or no rating at all to support weight-loss claims.
What does Arimistane do?
Arimistane is a hormone-altering compound that inhibits the aromatase enzyme, which converts hormones like testosterone to estrogen. It has insufficient reliable evidence to support claims about athletic performance, muscle strength, erectile dysfunction, or sexual arousal. Regulators warn against aromatase inhibitor supplements due to safety concerns.
Can I take ShredOne with my blood thinner medication?
Possibly not without checking first. Several ingredients—indole-3-carbinol, buchu, dandelion, and resveratrol—may increase bleeding risk when combined with blood thinners like warfarin or aspirin. Talk with your doctor or pharmacist before adding ShredOne to your regimen.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ShredOne label
Go deeper

The Full Monographs Behind ShredOne’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Arimistane

Interacts with 4 drugs

Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohor...

Read the full Arimistane monograph → Herb & supplement monograph

Indole-3-carbinol

Interacts with 294 drugs

Indole-3-carbinol (I3C) is a compound formed when you eat cruciferous vegetables like broccoli and cabbage, and it is sold as a supplement mainly for hormone-related and cell-protective effe...

Read the full Indole-3-carbinol monograph → Herb & supplement monograph

Buchu

Interacts with 481 drugs

Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies are lacking, so its benefits are largely...

Read the full Buchu monograph → Herb & supplement monograph

Juniper

Interacts with 162 drugs

Juniper berry is a traditional herb best known for flavoring gin and for its folk use as a diuretic and digestive aid. Solid human evidence for its health benefits is limited, and it can irr...

Read the full Juniper monograph → Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph → Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph →
Sources

Sources & How We Checked

ShredOne's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 79 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Arimistane 1 reference
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed

See these in context on the Arimistane monograph →

Indole-3-carbinol 9 references
  1. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810-5. PubMed
  2. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123-9. PubMed
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Buchu 3 references
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Juniper 7 references
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Uva Ursi 8 references
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Dandelion 27 references
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Resveratrol 24 references
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