Stone Breaker Ingredients & Drug Interactions
by Herb Pharm
What is this page for?
First and foremost: checking Stone Breaker against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Stone Breaker is a dietary supplement by Herb Pharm with 4 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 1,155 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stone Breaker extract, Celery extract, Burdock extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
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HelloPharmacist Scorecard of Stone Breaker by Herb Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Stone Breaker contains four active ingredients: burdock extract, hydrangea root extract, celery extract, and chanca piedra (stone breaker plant) extract. These are combined with certified organic cane alcohol and distilled water in a liquid form.
Burdock is a traditional root used for skin and general wellness. Hydrangea root has been used historically as a diuretic.
Celery and chanca piedra are both traditionally associated with urinary and kidney support. The specific roles and potency of each ingredient in this blend aren't detailed in the product facts we hold.
Does it work?
Moderate evidence
The evidence behind these ingredients is limited. Chanca piedra is rated Possibly Effective for kidney stones — the main use this product targets — but stronger evidence is needed.
For burdock, no reliable evidence supports its use for acne, aging skin, breast cancer, common cold, or eczema. Celery shows insufficient evidence for sexual dysfunction, anxiety, headache, depression, diabetes, or digestive upset.
Hydrangea's effectiveness for any specific condition isn't established in the data we hold. If you're considering this for kidney stone prevention or management, talk with your doctor about whether the current evidence supports it for your situation.
How safe is it?
Well-documented data
Burdock is likely safe as a food and for short-term use in healthy adults, though human safety data are limited. It's generally well tolerated, but rare allergic reactions including contact dermatitis and anaphylaxis have occurred.
One case of liver injury was reported after taking an herbal blend containing burdock, though it's unclear whether burdock or other ingredients were responsible. Hydrangea may cause gastroenteritis, dizziness, or chest tightness, and safety data are limited.
Celery is generally well tolerated as food but concentrates in supplements carry allergy risk — oral allergy syndrome (itching and burning in the mouth), contact dermatitis, and rare anaphylaxis have been reported. Photosensitivity is possible with celery.
Chanca piedra is often well tolerated short-term but may cause abdominal pain, nausea, vomiting, or fatigue; comprehensive safety data are lacking. All four ingredients lack adequate safety data in pregnancy and breastfeeding — see the pregnancy/breastfeeding section below.
Meds to double-check
Moderate interaction found
Before taking Stone Breaker, double-check with your own pharmacist or doctor if you use blood thinners or antiplatelet drugs (like warfarin or aspirin), as burdock, celery, and chanca piedra theoretically increase bleeding risk. Also check if you take lithium (a mood stabilizer) — hydrangea and celery may theoretically raise its levels.
If you're on venlafaxine (an antidepressant), levothyroxine (thyroid medication), norepinephrine (a blood pressure support drug), or drugs processed by the liver through CYP1A2 or CYP3A4 pathways, mention this product to your pharmacist. Anyone on blood pressure medication, diabetes medication, or photosensitizing drugs should confirm it's safe to combine before starting.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Stone Breaker is a traditional herbal blend aimed at kidney and urinary support, with chanca piedra rated Possibly Effective for kidney stones but other ingredients lacking strong evidence. If you take any blood thinners, mood stabilizers like lithium, antidepressants, thyroid medication, blood pressure drugs, diabetes medication, or photosensitizing drugs, check your specific medications with the tool on this page before starting.
Talk with your own doctor or pharmacist to make sure it's right for your situation and won't interfere with anything you're already taking.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Stone Breaker, straight from the product label.
| Brand | Herb Pharm |
|---|---|
| Barcode (UPC) | 090700014452 |
| Net contents | 2 fl. Oz.; 60 mL |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2023 |
| DSLD ID | 273157 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Stone Breaker by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Burdock extract | 0 NP | -- |
| Hydrangea Root Extract | 0 NP | -- |
| Celery extract | 0 NP | -- |
| Proprietary Extract Blend | 625 mg | -- |
| Stone Breaker extract | 0 NP | -- |
Other ingredients: certified organic Cane Alcohol, distilled Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use Shake well before using Add 1 full squeeze of the dropper bulb to 8 oz. of water or juice, 3 times per day. Best taken between meals.
Precautions
Caution: Seek expert medical advice before taking during pregnancy.
Keep out of the reach of children
Storage
Store away from heat & light
Formulation
System restoration Urinary
Gluten-free
FDA Statement of Identity
Herbal Supplement
Formula
Stone breaker compound
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Stone Breaker by Herb Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Stone Breaker by Herb Pharm
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container84 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
Other (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.
Stone Breaker by Herb Pharm Drug Interactions
HelloPharmacist Interaction Report
Stone Breaker by Herb Pharm interacts with medications through its burdock, hydrangea, celery, and chanca piedra extracts.
The most serious documented interaction is Moderate: celery and chanca piedra may theoretically increase bleeding risk when combined with blood thinners or antiplatelet drugs (like warfarin or aspirin), though this hasn't been reported in humans yet.
Read the full breakdown — every affected drug type, severity by severity
Celery poses the broadest interaction profile. It may theoretically raise levels of certain antidepressants (venlafaxine) and drugs processed through a liver pathway called CYP1A2, and lower the effectiveness of thyroid medication (levothyroxine).
It can also theoretically add to blood pressure-lowering drugs and raise sun-sensitivity risk with photosensitizing medications. Chanca piedra may theoretically reduce the effect of the blood pressure drug norepinephrine and raise levels of drugs processed through another liver pathway (CYP3A4).
Hydrangea and burdock each carry a Moderate theoretical risk with lithium (a mood stabilizer) — both may increase lithium levels.
Additionally, chanca piedra may theoretically boost diuretic effects or affect blood sugar control with diabetes medications. Altogether, these interactions span 1,156 individual medications.
None of these interactions have been confirmed in people. Check your exact medications with the search tool on this page, and talk with your own doctor or pharmacist before starting, stopping, or combining this product with any prescription drug.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Stone Breaker?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Stone Breaker interact with 1,155 drugs. Click any drug to see the details.
4 of the 4 ingredients in Stone Breaker interact with drugs. Each result below shows which ingredient is responsible. Stone Breaker extract Celery extract Burdock extract Hydrangea Root Extract
Fluticasone Proprionate, SalmeterolAirduo Respiclick
How Fluticasone Proprionate, Salmeterol interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fluticasone Proprionate, Salmeterol interactionFluticasone FuroateArnuity Ellipta, Avamys
How Fluticasone Furoate interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fluticasone Furoate interactionFluticasone, SalmeterolAdvair Diskus
How Fluticasone, Salmeterol interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fluticasone, Salmeterol interactionFluvoxamineLuvox
How Fluvoxamine interacts with Stone Breaker — through 2 ingredients. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Stone Breaker Extract + Fluvoxamine interactionCelery ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Photosensitizing Drugs Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Extract + Fluvoxamine interactionFondaparinuxArixtra
How Fondaparinux interacts with Stone Breaker — through 3 ingredients. Tap an ingredient for the detail:
Celery ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Celery Extract + Fondaparinux interactionStone Breaker ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
Read the full Stone Breaker Extract + Fondaparinux interactionBurdock ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock Extract + Fondaparinux interactionFosamprenavirLexiva, Telzir
How Fosamprenavir interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fosamprenavir interactionFosaprepitantEmend Injection, Focinvez
How Fosaprepitant interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fosaprepitant interactionFosinoprilMonopril
How Fosinopril interacts with Stone Breaker — through 2 ingredients. Tap an ingredient for the detail:
Celery ExtractAntihypertensive Drugs, Photosensitizing Drugs Moderate
Interaction Summary
Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Read the full Celery Extract + Fosinopril interactionStone Breaker ExtractAntihypertensive Drugs Minor
Interaction Summary
Theoretically, concomitant use of chanca piedra with antihypertensive drugs might have additive blood pressure lowering effects.
Read the full Stone Breaker Extract + Fosinopril interactionFosinopril, HydrochlorothiazideMonopril HCT
How Fosinopril, Hydrochlorothiazide interacts with Stone Breaker — through 2 ingredients. Tap an ingredient for the detail:
Celery ExtractPhotosensitizing Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery Extract + Fosinopril, Hydrochlorothiazide interactionStone Breaker ExtractDiuretic Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Read the full Stone Breaker Extract + Fosinopril, Hydrochlorothiazide interactionFosnetupitant, Palonosetron (iv)Akynzeo
How Fosnetupitant, Palonosetron (iv) interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fosnetupitant, Palonosetron (iv) interactionFostamatinibTavalisse
How Fostamatinib interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fostamatinib interactionFostemsavir TromethamineRukobia
How Fostemsavir Tromethamine interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fostemsavir Tromethamine interactionFruquintinibFruzaqla
How Fruquintinib interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Fruquintinib interactionFurosemideLasix
How Furosemide interacts with Stone Breaker — through 2 ingredients. Tap an ingredient for the detail:
Celery ExtractPhotosensitizing Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery Extract + Furosemide interactionStone Breaker ExtractDiuretic Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Read the full Stone Breaker Extract + Furosemide interactionFurosemide, PotassiumDiumide-K Continus, Lasikal
How Furosemide, Potassium interacts with Stone Breaker — through 2 ingredients. Tap an ingredient for the detail:
Stone Breaker ExtractDiuretic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Read the full Stone Breaker Extract + Furosemide, Potassium interactionCelery ExtractPhotosensitizing Drugs Minor
Interaction Summary
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Read the full Celery Extract + Furosemide, Potassium interactionFutibatinibLytgobi
How Futibatinib interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Futibatinib interactionGalantamineRazadyne, Reminyl
How Galantamine interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Galantamine interactionGalantamine Extended ReleaseRazadyne ER
How Galantamine Extended Release interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Galantamine Extended Release interactionGanaxoloneZtalmy
How Ganaxolone interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Ganaxolone interactionGefitinibIressa
How Gefitinib interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Gefitinib interactionGepironeExxua
How Gepirone interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Gepirone interactionGilteritinib FumarateXospata
How Gilteritinib Fumarate interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Gilteritinib Fumarate interactionGlasdegibDaurismo
How Glasdegib interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Glasdegib interactionGlecaprevir, PibrentasvirMavyret
How Glecaprevir, Pibrentasvir interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Glecaprevir, Pibrentasvir interactionGlycopyrrolate, Indacaterol MaleateUtibron
How Glycopyrrolate, Indacaterol Maleate interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Glycopyrrolate, Indacaterol Maleate interactionGrepafloxacinRaxar
How Grepafloxacin interacts with Stone Breaker — through 2 ingredients. Tap an ingredient for the detail:
Celery ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
Read the full Celery Extract + Grepafloxacin interactionStone Breaker ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
Read the full Stone Breaker Extract + Grepafloxacin interactionGuaifenesin, HydrocodoneEntuss, Pneumotussin
How Guaifenesin, Hydrocodone interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Guaifenesin, Hydrocodone interactionGuaifenesin, Hydrocodone BitartrateFlowtuss, Obredon
How Guaifenesin, Hydrocodone Bitartrate interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Guaifenesin, Hydrocodone Bitartrate interactionGuaifenesin, Hydrocodone Bitartrate, Pseudoephedrine HydrochlorideHycofenix
How Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride interactionGuaifenesin, Hydrocodone, PseudoephedrineEntuss-D, Tussi-Organidin DM NR
How Guaifenesin, Hydrocodone, Pseudoephedrine interacts with Stone Breaker — through 1 ingredient. Tap an ingredient for the detail:
Stone Breaker ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
Read the full Stone Breaker Extract + Guaifenesin, Hydrocodone, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Stone Breaker with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Stone Breaker extract
Anticoagulant/Antiplatelet Drugs
Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In vitro research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can inhibit platelet aggregation. This effect has not been reported in humans.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that chanca piedra extract increases CYP1A2 activity. Theoretically, chanca piedra might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that chanca piedra extract inhibits CYP3A4. Theoretically, chanca piedra might increase the levels of CYP3A4 substrates. This interaction has not been reported in humans.
Diuretic Drugs
Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking diuretic drugs.
Lithium
Theoretically, chanca piedra might reduce excretion and increase levels of lithium.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows that taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking lithium. The dose of lithium might need to be decreased.
Norepinephrine (Levophed)
Theoretically, chanca piedra may reduce the effects of norepinephrine.
Animal research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can reverse blood vessel contraction caused by norepinephrine.
Antidiabetes Drugs
Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Animal research suggests that chanca piedra can have hypoglycemic effects. However, a small clinical study in adults with diabetes shows that chanca piedra extract 25 grams orally daily for 1 week does not lower fasting or postprandial blood glucose levels.
Antihypertensive Drugs
Theoretically, concomitant use of chanca piedra with antihypertensive drugs might have additive blood pressure lowering effects.
Animal research suggests that chanca piedra can decrease blood pressure. However, this effect was not observed in most hypertensive patients treated with chanca piedra for 10 days.
Celery extract
Anticoagulant/Antiplatelet Drugs
Theoretically, celery root might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Celery root contains the constituents falcarinol and falcarindiol. Laboratory research suggests that these constituents can inhibit platelet aggregation. This effect has not been reported in humans.
Antihypertensive Drugs
Theoretically, celery seed extract might have additive effects with antihypertensive drugs.
Clinical research suggests that taking celery seed extract may reduce daytime systolic blood pressure by about 12 mmHg compared to less than 1 mmHg with placebo.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggests that constituents of celery can inhibit CYP1A2. This effect has not been reported in humans.
Levothyroxine (Synthroid, Others)
Theoretically, celery seed might decrease the effects of levothyroxine.
Several cases of hypothyroidism with low T4 levels have been reported in people who were previously stabilized on levothyroxine and then started taking celery seed tablets. They presented with symptoms such as lethargy, bloating, and dry skin, and recovered when celery seed was stopped. However, celery stem and leaf has been associated with case reports of hyperthyroidism in patients with no pre-existing thyroid disorders.
Lithium
Theoretically, celery might reduce excretion and increase levels of lithium due to potential diuretic effects.
Celery is thought to have diuretic properties. However, this effect has not been confirmed in humans.
Venlafaxine (Effexor)
Theoretically, celery root extract might increase blood levels of venlafaxine.
There is one case report of a patient who experienced medication-induced bipolar disorder after beginning to take celery root extract 1000 mg daily along with venlafaxine 75 mg and St. John's wort 600 mg daily. Symptoms included confusion, speech abnormalities, manic affect, and visual hallucinations. The plasma level of venlafaxine was 476.8 ng/mL (normal range 195-400 ng/mL). It is theorized that celery root increased venlafaxine levels by inhibiting cytochrome P450 2D6.
Acetaminophen (Tylenol, Others)
Theoretically, celery juice might increase the effects and side effects of acetaminophen.
Animal research suggests that concomitant use of celery juice plus acetaminophen prolongs the effects of acetaminophen. This effect has been attributed to a decrease in hepatic cytochrome P450 activity. However, other animal research shows that pretreatment with celery root extract protects against acetaminophen-induced acute liver failure. These effects have not been reported in humans.
Photosensitizing Drugs
Theoretically, celery might increase the risk of photosensitivity reactions when taken with photosensitizing drugs.
Laboratory research shows that celery contains photosensitizing agents such as phenols and psoralens.
Burdock extract
Anticoagulant/Antiplatelet Drugs
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.
Hydrangea Root Extract
Lithium
Hydrangea is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, hydrangea might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Stone Breaker, from the product label.
Herb Pharm
See all Herb Pharm products- Name
- Herb Pharm
- City
- Williams
- State
- OR
- ZipCode
- 97544
- Phone Number
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Stone Breaker by Herb Pharm: Common Questions
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How can one product interact with so many drugs?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Stone Breaker’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Burdock
Interacts with 122 drugsBurdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...
Read the full Burdock monograph → Herb & supplement monographHydrangea
Interacts with 1 drugHydrangea root has a long history in folk medicine, mainly for urinary and kidney stone complaints, but there is very little modern human research to confirm it works for any condition. Beca...
Read the full Hydrangea monograph → Herb & supplement monographCelery
Interacts with 651 drugsCelery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint discomfort. Human evidence for these supplement use...
Read the full Celery monograph → Herb & supplement monographChanca Piedra
Interacts with 1,020 drugsChanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence for these uses is limited and mostly smal...
Read the full Chanca Piedra monograph →Sources & How We Checked
Stone Breaker's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 78 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Burdock 11 references
- Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
- Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
- Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
- Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
- Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
- Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
- Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
- Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
- <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
- Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
- Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
Hydrangea 1 reference
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Celery 48 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603.
- Moses, G. Thyroxine interacts with celery seed tablets? Australian Prescriber 2001;24:6-7. DOI
- Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. PubMed
- Jakovljevic, V., Raskovic, A., Popovic, M., and Sabo, J. The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Eur.J Drug Metab Pharmacokinet. 2002;27(3):153-156. PubMed
- Wang, L., Sterling, B., and Don, P. Berloque dermatitis induced by "Florida water". Cutis 2002;70(1):29-30.
- Weber, I. C., Davis, C. P., and Greeson, D. M. Phytophotodermatitis: the other "lime" disease. J Emerg.Med 1999;17(2):235-237. PubMed
- Rueff, F., Eberlein-Konig, B., and Przybilla, B. Oral hyposensitization with celery juice. Allergy 2001;56(1):82-83. PubMed
- Lombaert, G. A., Siemens, K. H., Pellaers, P., Mankotia, M., and Ng, W. Furanocoumarins in celery and parsnips: method and multiyear Canadian survey. J AOAC Int 2001;84(4):1135-1143. DOI
- Ballmer-Weber, B. K., Hoffmann, A., Wuthrich, B., Luttkopf, D., Pompei, C., Wangorsch, A., Kastner, M., and Vieths, S. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy PubMed
- Hoerler, S. and Ukiwe, J. Laryngeal edema from celery allergic reaction. Am.J.Emerg.Med. 1992;10(6):613. PubMed
- DeLeo, V. A. Photocontact dermatitis. Dermatol Ther 2004;17(4):279-288. PubMed
- Groot, B. J., Belinfante-van Gelder, M. E., and Jans, H. W. [An epidemic of dermatitis caused by blanched celery]. Ned.Tijdschr.Geneeskd. 6-20-1992;136(25):1210-1213.
- Erdmann, S. M., Sachs, B., Schmidt, A., Merk, H. F., Scheiner, O., Moll-Slodowy, S., Sauer, I., Kwiecien, R., Maderegger, B., and Hoffmann-Sommergruber, K. In vitro analysis of birch-pollen-associated food allergy by use of recombinant allergens in the b
- Jeanmougin, M., Varroud-Vial, C., and Dubertret, L. [Phototoxic side-effect following celery ingestion during puvatherapy]. Ann.Dermatol Venereol 2005;132(6-7 Pt 1):566-567.
- Christensen, L. P. and Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. J Pharm.Biomed.Anal. 6-7-2006;41(3):683-693. PubMed
- Gorgus, E., Lohr, C., Raquet, N., Guth, S., and Schrenk, D. Limettin and furocoumarins in beverages containing citrus juices or extracts. Food Chem.Toxicol. 2010;48(1):93-98. PubMed
- Maso, M. J., Ruszkowski, A. M., Bauerle, J., DeLeo, V. A., and Gasparro, F. P. Celery phytophotodermatitis in a chef. Arch.Dermatol. 1991;127(6):912-913. DOI
- Ljunggren, B. Severe phototoxic burn following celery ingestion. Arch.Dermatol. 1990;126(10):1334-1336. DOI
- Held, J. L. Phytophotodermatitis. Am Fam.Physician 1989;39(4):143-146.
- Silverstein, S. R., Frommer, D. A., Dobozin, B., and Rosen, P. Celery-dependent exercise-induced anaphylaxis. J.Emerg.Med. 1986;4(3):195-199. PubMed
- Rose, M. H. and Altman, L. C. Anaphylaxis after ingestion of raw celery. Ann.Allergy 1985;54(2):166.
- Forsbeck, M. and Ros, A. M. Anaphylactoid reaction to celery. Contact Dermatitis 1979;5(3):191. PubMed
- DeChamp, C., Michel, J., Deviller, P., and Perrin, L. F. [Anaphylactic shock to celery and sensitization to ragweed and mugwort. Crossed or concomitant allergy?]. Presse Med. 3-31-1984;13(14):871-874.
- Johansson, S. G., Dannaeus, A., and Lilja, G. The relevance of anti-food antibodies for the diagnosis of food allergy. Ann.Allergy 1984;53(6 Pt 2):665-672.
- Beier, R. C., Ivie, G. W., Oertli, E. H., and Holt, D. L. HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). Food Chem.Toxicol. 1983;21(2):163-165. PubMed
- Kidd, J. M., III, Cohen, S. H., Sosman, A. J., and Fink, J. N. Food-dependent exercise-induced anaphylaxis. J Allergy Clin Immunol 1983;71(4):407-411. PubMed
- Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. A new French multicenter survey]. Ann.Gastroenterol Hepatol (Paris) 1995;31(4):256-263.
- Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery]. Allerg.Immunol.(Paris) 1995;27(6):209.
- Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery cross-reacting with ragweed]. Allerg.Immunol.(Paris) 1995;27(3):91-93.
- Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. A new French multicenter study]. Bull.Acad.Natl.Med 1995;179(1):161-184.
- Puig, L. and de Moragas, J. M. Enhancement of PUVA phototoxic effects following celery ingestion: cool broth also can burn. Arch.Dermatol. 1994;130(6):809-810. DOI
- Egan, C. L. and Sterling, G. Phytophotodermatitis: a visit to Margaritaville. Cutis 1993;51(1):41-42.
- Boffa, M. J., Gilmour, E., and Ead, R. D. Celery soup causing severe phototoxicity during PUVA therapy. Br.J.Dermatol. 1996;135(2):334.
- Wuthrich, B., Borga, A., and Yman, L. Oral allergy syndrome to a jackfruit (Artocarpus integrifolia). Allergy 1997;52(4):428-431.
- Peterson, S., Lampe, J. W., Bammler, T. K., Gross-Steinmeyer, K., and Eaton, D. L. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem.Toxicol. 2006;44(9):147 PubMed
- Baek CH, Bae YJ, Cho YS, Moon HB, Kim TB. Food-dependent exercise-induced anaphylaxis in the celery-mugwort-birch-spice syndrome. Allergy. 2010;65(6):792-3. PubMed
- Khalid Z, Osuagwu FC, Shah B, Roy N, Dillon JE, Bradley R. Celery root extract as an inducer of mania induction in a patient on venlafaxine and St John's Wort. Postgrad Med. 2016;128(7):682-3. PubMed
- Palgan K, Götz-Zbikowska M, Tykwinska M, Napiórkowska K, Bartuzi Z. Celery-cause of severe anaphylactic shock. Postepy Hig Med Dosw (Online). 2012;66:132-4.
- Maljaei MB, Moosavian SP, Mirmosayyeb O, Rouhani MH, Namjoo I, Bahreini A. Effect of celery extract on thyroid function; is herbal therapy safe in obesity? Int J Prev Med 2019;10:55. doi: 10.4103/ijpvm.IJPVM_209_17. PubMed
- Rouhi-Boroujeni H, Hosseini M, Gharipour M, Rouhi-Boroujeni H. Is herbal therapy safe in obesity? A case of Apium graveolens (Celery) induced hyperthyroidism. ARYA Atheroscler 2016;12(5):248-9.
- Emad AM, Ali SF, Abdel-Rahman EA, et al. Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity. J Food Biochem 2020:e13399. Online ahead of print.
- Shayani Rad M, Moohebati M, Mohajeri SA. Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple-blind, placebo-controlled, cross-over, clinical trial. Phytother Res 2022.
- Azimi M, Zahedi MJ, Raeiszadeh M, Iraji A, Cramer H, Pasalar M. Efficacy and Safety of a Persian Medicine Formula on Functional Dyspepsia Symptoms: A Randomized Double-Blind Active-Control Clinical Trial. Complement Med Res 2023;30(3):238-247. PubMed
- Ukleja-Sokolowska N, Lis K, Graczyk M, Bartuzi M, Bartuzi Z. The use of inhibition assay in Api g 7 suspected allergy in a female patient with anaphylaxis: A case report. Int J Immunopathol Pharmacol 2024;38:3946320231223004. PubMed
Chanca Piedra 18 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Indian J Exp Biol 1995; 33:861-4.
- Rao, M. V. and Alice, K. M. Contraceptive effects of Phyllanthus amarus in female mice. Phytother.Res 2001;15(3):265-267.
- Moshi, M. J., Lutale, J. J., Rimoy, G. H., Abbas, Z. G., Josiah, R. M., and Swai, A. B. The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Phytother.Res 2001;15(7):577-580.
- Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol.Res 2004;32(5):362-366. PubMed
- Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol.Pharm.Bull. 2006;29(1):177-179. PubMed
- Adeneye, A. A., Amole, O. O., and Adeneye, A. K. Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia 2006;77(7-8):511-514. PubMed
- Iizuka, T., Nagai, M., Taniguchi, A., Moriyama, H., and Hoshi, K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol.Pharm.Bull. 2007;30(2):382-384. PubMed
- Amaechina, F. C. and Omogbai, E. K. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol.Pharm. 2007;64(6):547-552.
- Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., and Salawu, O. A. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm.Biol. 2011;49(3):248-255.
- Moshi MJ, Uiso FC Mahunnah RL et al. A study of the effect of Phyllanthus amarus extracts on blood glucose in rabbits. International Journal of Pharmacognosy 1997;35(3):167-173. DOI
- Kumar NG, Nair AN Raghunandanan VR et al. Hypoglycaemic effect of Phyllanthus niruri leaves in rabbits. Kerala Journal of Veterinary Science 1989;20(1):77-80.
- Navarro M, Coussio J Hnatyszyn O et al. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Acta Farmaceutica Bonaerense 2004;23:520-523.
- Etta HE, Udoh PB Asuquo BO et al. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Global Journal of Agricultural Sciences 2007;215-217. DOI
- Etta H. Effects of Phyllanthus amarus on litter traits in albino rats. Scientific Research and Essays 2008;370-372.
- Pucci ND, Marchini GS, Mazzucchi E, et al. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol 2018;44(4):758-64. PubMed
- Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J Pharmacol 2021;53(6):448-456. PubMed
- Husain I, Abdulrahman B, Dale OR, et al. Interaction of Phyllanthus amarus extract and its lignans with human xenobiotic receptors, drug metabolizing enzymes and drug transporters. J Ethnopharmacol 2025;339:119142. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC