Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Super 5 Lozenge Probiotic Ingredients & Drug Interactions

by Flora

Super 5 Lozenge Probiotic label
See full label image
Lozenge Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super 5 Lozenge Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super 5 Lozenge Probiotic is a dietary supplement by Flora with 5 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus HA-122, Bifidobacterium bifidum HA-132. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super 5 Lozenge Probiotic by Flora

Ask about any prescription or over-the-counter medication and we check it for interactions with Super 5 Lozenge Probiotic by Flora — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super 5 Lozenge Probiotic by Flora

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Super 5 Probiotic Blend” is a proprietary blend — the label gives one combined amount (139.60 mg) without saying how much of each component you get.

This lozenge delivers five active probiotic strains: Lactobacillus casei HA-108, Lactobacillus rhamnosus HA-111, Lactobacillus acidophilus HA-122, Bifidobacterium bifidum HA-132, and Lactobacillus salivarius HA-118. These are beneficial bacteria meant to support your gut health.

The product also contains inactive ingredients like maltodextrin, xylitol, microcrystalline cellulose, natural raspberry flavor, ascorbic acid, citric acid, magnesium stearate, and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: healthy digestion and intestinal flora.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Travelers' diarrhea, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

For Lactobacillus acidophilus, the data shows it's possibly effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, Helicobacter pylori, and bacterial vaginosis. For Bifidobacterium bifidum, the evidence is possibly effective for IBS and respiratory tract infections.

For the other three strains in this product, we hold no effectiveness ratings. The evidence for some conditions — like Alzheimer's disease and generalized anxiety disorder — is too thin to rate.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both checked ingredients are generally well tolerated in healthy adults and children. That said, the data are limited, so talk with your doctor before starting.

Because these are live microorganisms, there's a theoretical risk of infection in people with weakened immune systems — though serious cases are rare. Gastrointestinal side effects like bloating, flatulence, and abdominal discomfort can occur but are uncommon.

A small number of trial participants reported rash or itching, though it's unclear whether the probiotics were responsible.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, separate them from this product — antibiotics can kill the live bacteria in the supplement and make it less effective. Ask your pharmacist how far apart to take them.

We couldn't check three of the five probiotic strains for interactions, so use the medication checker below for your full list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, respiratory health, or diarrhea after antibiotics, depending on which strain does the work. If you're on antibiotics, space them out from this supplement so the bacteria don't get killed off.

People with weakened immunity should check with their doctor first. Run your medications through our tool before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super 5 Lozenge Probiotic, straight from the product label.

Brand Flora
Barcode (UPC) 061998619506
Net contents 60 Lozenge(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 265490
Product type Non-nutrient/non-botanical
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super 5 Lozenge Probiotic by Flora, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
2 Lozenge(s)
Servings per container
30
UPC/BARCODE
061998619506
IngredientAmount% DV
Lactobacillus casei HA-1080 NP--
Lactobacillus rhamnosus HA-1110 NP--
Lactobacillus acidophilus HA-1220 NP--
Bifidobacterium bifidum HA-1320 NP--
Lactobacillus salivarius HA-1180 NP--
Super 5 Probiotic Blend139.6 mg--

Other ingredients: Maltodextrin, Xylitol, Microcrystalline Cellulose, natural Raspberry flavor, Ascorbic Acid, Citric Acid, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Super 5 Probiotic includes 5 strains of beneficial bacteria that provide support for healthy digestion, fresh breath, and intestinal flora.

The delicious raspberry flavor makes it easy for children and adults to take.

2 billion cells at time of manufacture Raw probiotics

Minimum 2 billion viable cells per lozenge at time of manufacture. (Minimum 1 billion viable cells per lozenge at printed two year expiration date.)

Formulation

Ideal for travelers to maintain healthy flora while away from home. Since probiotics are living organisms, their potency slowly decreases over time (2% per month).

Gluten free!

Supports fresh breath

Product of Canada

Storage

Keep refrigerated whenever possible and freeze to prolong shelf life.

For maximum potency keep product refrigerated. Freeze to prolong shelf life.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Precautions

Contains traces of milk and soy.

Caution: As with any dietary supplement, consult a physician if taking prescription medications or if you have a medical condition.

Security sealed for your protection. Do not use if seal is missing or damaged.

Suggested/Recommended/Usage/Directions

Suggested Use: Dissolve 1 lozenge gently in mouth after each meal. For extra strength, take 2 lozenges after each meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super 5 Lozenge Probiotic by Flora label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super 5 Lozenge Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super 5 Lozenge Probiotic by Flora

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Super 5 Probiotic Blend

139.6 mg per serving

Other (inactive) ingredients: Maltodextrin, Xylitol, Microcrystalline Cellulose, Natural Raspberry flavor, Ascorbic Acid, Citric Acid, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super 5 Lozenge Probiotic by Flora Drug Interactions

Want to check YOUR meds against Super 5 Lozenge Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus HA-122 182
Bifidobacterium bifidum HA-132 182

Individual Drug Interactions

The ingredients in Super 5 Lozenge Probiotic interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in Super 5 Lozenge Probiotic interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus HA-122 Bifidobacterium bifidum HA-132

Each ingredient & the kinds of drugs it affects

For each ingredient in Super 5 Lozenge Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus HA-1221 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus HA-122 full monograph & interactions

Bifidobacterium bifidum HA-1321 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum HA-132 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super 5 Lozenge Probiotic, from the product label.

Flora

See all Flora products
Name
FLORA INC.
Street Address
805 E. BADGER RD.
City
LYNDEN
State
WA
ZipCode
98264
Phone Number
1.800.446.2110
Web Address
www.florahealth.com
Pharmacist Counseling Corner

Super 5 Lozenge Probiotic by Flora: Common Questions

Does Super 5 Lozenge Probiotic by Flora interact with any medications?
Yes. Based on its ingredients, Super 5 Lozenge Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super 5 Lozenge Probiotic contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
You can, but timing matters. Antibiotics can kill the live organisms in this supplement and reduce how well it works. Your pharmacist can help you space them out properly — usually a few hours apart is enough.
What's this lozenge supposed to do?
The probiotics inside are possibly effective for irritable bowel syndrome, respiratory infections, and diarrhea that follows antibiotic use. The evidence is strongest for IBS. Results vary from person to person.
Are there any common side effects?
Gas, bloating, and abdominal discomfort can happen, but they're uncommon. A small number of people in trials reported rash or itching, though we can't be sure the probiotics caused it.
Is this safe if my immune system is weak?
These probiotics are generally well tolerated, but because they're live organisms, people with weakened immune systems should talk to their doctor first. Serious infections from them are rare, but it's worth a conversation.
What exactly are these five strains and why does it matter?
Each strain is a different beneficial bacteria. Lactobacillus acidophilus and Bifidobacterium bifidum have evidence behind them for certain conditions. We don't have effectiveness data for the other three strains in this product, so their individual benefits aren't clear from our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Super 5 Lozenge Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super 5 Lozenge Probiotic label
Go deeper

The Full Monographs Behind Super 5 Lozenge Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

Super 5 Lozenge Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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