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Dietary supplement

Superior Cissus Ingredients & Drug Interactions

by InnovaPharm

Superior Cissus label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Superior Cissus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Superior Cissus is a dietary supplement by InnovaPharm with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are QuadraFlex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Superior Cissus by InnovaPharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Superior Cissus by InnovaPharm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Superior Cissus by InnovaPharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Superior Cissus contains one active ingredient: Cissus quadrangularis (a plant extract also called QuadraFlex). The product also includes gelatin, magnesium stearate, silicon dioxide, and rice flour as inactive ingredients to hold the capsule together and improve how it's manufactured.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support bone joint and connective tissue health.
  • We looked for evidence on: Fractures, Joint pain, Osteopenia, Osteoporosis, Rheumatoid arthritis (RA), Muscle strength — and 3 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteopenia (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Muscle strength, Osteoporosis, Joint pain, and more.

Cissus quadrangularis is possibly effective for obesity — small studies hint it may help with weight management. For high cholesterol (hyperlipidemia), bone density loss (osteopenia), cancer, and epilepsy, the evidence we have isn't strong enough to say whether it works or not.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, though long-term safety hasn't been well studied. The most commonly reported side effects in trials — headache, insomnia, flatulence, diarrhea, stomach irritation, and dry mouth — occurred at rates similar to or lower than placebo.

There isn't enough safety data to recommend this supplement during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes medication — insulin, metformin, sulfonylureas, or any other glucose-lowering drug — double-check it with our medication tool before you start this supplement. The risk of low blood sugar (Moderate severity) needs careful monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in this supplement for weight management and don't take antidiabetes medication, it's worth a conversation with your pharmacist. If you take any diabetes drugs, check them against our medication tool first — the risk of low blood sugar is real.

Long-term safety data is limited, so this isn't something to take indefinitely without professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Superior Cissus, straight from the product label.

Brand InnovaPharm
Barcode (UPC) 682500369995
Net contents 180 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299187
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Superior Cissus by InnovaPharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
682500369995
IngredientAmount% DV
QuadraFlex4800 mg--

Other ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Superior Cissus contains a highly dosed engineered extract of Cissus Quadrangularis known as QuadraFlex.

Formulation

This unique herbal extract has been shown to support bone, joint and connective tissue health. Whether you are a competitive bodybuilder, powerlifter, collegiate athlete or weekend warrior, Superior Cissus can provide a multitude of benefits to the active male and female.

Powerful connective tissue support

100% Shellfish free

Supports a healthy inflammatory response Maximum strength formula Promotes bone & joint health

Allergen Information: Not manufactured with wheat, gluten, soy, fish, shellfish, egg, milk or tree nut ingredients.

Precautions

Warning: This product is only intended to be consumed by healthy adults, 18 years of age or older. Keep out of reach of children.

Do not use if you are pregnant or nursing. Before using this product, consult with a licensed, qualified, health care professional, including but not limited to, if you suspect you have or have been treated for, diagnosed with or have a family history of any medical condition, or if you are using any prescription or over the counter medication.

Do not use this product if you have any serious medical conditions. Immediately discontinue use and contact a medical doctor if you experience any adverse reaction to this product. Discontinue use 2 weeks prior to surgery. Do not use if safety seal is broken or missing.

Allergen Information: Not manufactured with wheat, gluten, soy, fish, shellfish, egg, milk or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Storage

Store in a cool dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 3 capsules twice daily with food.

General Statements

Twitter Instagram Facebook Follow Us: @InnovaPharm

Brand IP Statement(s)

QuadraFlex is a Registered Trademark of Nova Naturals

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Superior Cissus by InnovaPharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Superior Cissus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Superior Cissus by InnovaPharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

QuadraFlex

Interacts with
86 drugs
4800 mg per serving Form: Cissus quadrangularis Stem Extract

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

QuadraFlex monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Superior Cissus by InnovaPharm Drug Interactions

Want to check YOUR meds against Superior Cissus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

QuadraFlex 86

Individual Drug Interactions

The ingredients in Superior Cissus interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Superior Cissus interact with drugs. Each result below shows which ingredient is responsible. QuadraFlex

Each ingredient & the kinds of drugs it affects

For each ingredient in Superior Cissus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

QuadraFlex1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
QuadraFlex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Superior Cissus, from the product label.

InnovaPharm

See all InnovaPharm products
Name
InnovaPharm
Street Address
53 E Merrick Rd. #215
City
Freeport
State
NY
ZipCode
11520
Web Address
InnovaPharm.com
Pharmacist Counseling Corner

Superior Cissus by InnovaPharm: Common Questions

Does Superior Cissus by InnovaPharm interact with any medications?
Yes. Based on its ingredients, Superior Cissus has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Superior Cissus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me lose weight?
Cissus quadrangularis is possibly effective for obesity based on the evidence we have, but small studies suggest it works best as part of a broader approach. Talk with your pharmacist or doctor about realistic expectations and whether it's right for your situation.
What are the most common side effects?
Headache, insomnia, bloating, diarrhea, stomach irritation, and dry mouth have been reported, but they occurred at rates similar to or lower than placebo in trials. Most people tolerate it well in the short term.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data, so it's best avoided during pregnancy and while breastfeeding. Talk with your doctor or pharmacist to discuss what's right for you.
How long is it safe to take?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. This isn't something to take indefinitely — check in with your pharmacist about how long you should use it.
What is QuadraFlex?
QuadraFlex is the branded extract of Cissus quadrangularis, a plant used in traditional medicine. It's the single active ingredient in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Superior Cissus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Superior Cissus label
Go deeper

The Full Monographs Behind Superior Cissus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Superior Cissus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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