Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Test D-Aspartic Grape Ingredients & Drug Interactions

by ANS

Test D-Aspartic Grape label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Test D-Aspartic Grape against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Test D-Aspartic Grape is a dietary supplement by ANS with 5 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 407 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium D-Aspartic Acid, Mucuna Pruriens, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Test D-Aspartic Grape by ANS

Ask about any prescription or over-the-counter medication and we check it for interactions with Test D-Aspartic Grape by ANS — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Test D-Aspartic Grape by ANS

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 5 active ingredients.
  • “Testosterone & Nitric Oxide Matrix” is a proprietary blend — the label gives one combined amount (3,750 mg) without saying how much of each component you get.

ANS Test D-Aspartic Grape contains 5 active ingredients. Potassium and sodium help regulate fluid balance and blood pressure; glycine is an amino acid; L-Ornithine AKG is an amino acid derivative; and Mucuna pruriens is a plant extract containing levodopa, a compound that affects dopamine in the brain.

The powder also contains inactive ingredients — maltodextrin, natural and artificial flavors, potassium citrate, silicon dioxide, sucralose, and food colorings (FD&C Red 40 and Blue 1) — which serve as fillers, binders, and flavor.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: support healthy testosterone levels and male performance.
  • We looked for evidence on: Parkinson disease, Sexual desire, Physical performance, male fertility, libido, muscle function.
  • The closest evidence on file: Cowhage is rated "Insufficient Reliable Evidence To Rate" for Parkinson disease (Natural Medicines).
  • Also on file: Cowhage is rated "Insufficient Reliable Evidence To Rate" for Sexual desire.
  • Also on file: Glycine is rated "Insufficient Reliable Evidence To Rate" for Physical performance.

Evidence for this product's effectiveness is limited. Glycine is rated possibly effective for schizophrenia but has insufficient evidence for ADHD, benign prostatic hyperplasia, cystic fibrosis, or 3-PGDH deficiency.

Sodium D-aspartic acid shows evidence in cystic fibrosis and is possibly effective for amphotericin B kidney toxicity, but has insufficient evidence for bipolar disorder or congestive heart failure. Mucuna pruriens has insufficient evidence for anxiety, skin inflammation (erythema), high prolactin, muscle pain (myalgia), Parkinson disease, or rheumatoid arthritis.

No effectiveness ratings are available for potassium or L-Ornithine AKG in the data we hold.

The evidence, ingredient by ingredient Potassium Glycine Sodium Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium is generally well tolerated, but supplements can dangerously raise blood levels — especially in people with kidney disease — and cause abdominal pain, nausea, diarrhea, or in rare cases arrhythmia and low blood pressure. Glycine is generally well tolerated at typical doses, though long-term safety is unclear; rare side effects include mild sedation and memory problems.

Sodium is well tolerated at normal dietary amounts, but high intake is linked to high blood pressure, heart strain, kidney disease, and possibly gastric cancer. Mucuna pruriens contains a drug-like compound (levodopa) and should be used carefully; rare side effects include diarrhea, flatulence, nausea, headache, and insomnia in about 3% of those taking it at higher doses.

For pregnancy: potassium and sodium are likely safe at dietary amounts but supplements require your doctor's approval. Glycine has insufficient safety data, so avoid unless your doctor approves.

Mucuna pruriens is possibly unsafe in pregnancy. For breastfeeding: potassium and sodium supplements need your doctor's clearance; glycine has insufficient data; Mucuna pruriens should be avoided because levodopa can lower milk supply.

Side effects, ingredient by ingredient Potassium Glycine Sodium Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Potassium, Cowhage, Glycine, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; lithium; Parkinson's medications.
  • For scale: 407 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking ANS Test D-Aspartic Grape, check with your pharmacist or doctor if you take monoamine oxidase inhibitors (MAOIs) or methyldopa — Mucuna pruriens carries Major-severity risks of life-threatening blood pressure changes. Also check if you take potassium-sparing diuretics, ACE inhibitors (like lisinopril), or ARBs (like losartan) — potassium poses Moderate risk of dangerously high potassium.

Clear it too if you take antihypertensive drugs, corticosteroids, lithium, didanosine, or other sodium-containing drugs — sodium carries Moderate risk. Lastly, ask about antidiabetes drugs, antipsychotics, tricyclic antidepressants, anesthesia, guanethidine, and clozapine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is a multi-ingredient supplement with potassium, sodium, and an active plant compound (Mucuna pruriens) that all carry documented drug interactions — most notably Major-severity risks with blood pressure medications and MAOIs. Anyone taking prescription medications for blood pressure, heart, kidney, mood, diabetes, or psychosis should check their exact drugs with your pharmacist or doctor before starting this product.

Talk it over with your own healthcare provider to decide if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Test D-Aspartic Grape, straight from the product label.

Brand ANS
Barcode (UPC) 859582001277
Net contents 240 Gram(s); 8.5 oz.
Market status On market
Date entered into DSLD Feb 26, 2014
DSLD ID 30744
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Test D-Aspartic Grape by ANS, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Gram(s)
Maximum serving Sizes:
8 Gram(s)
Servings per container
30
UPC/BARCODE
859582001277
IngredientAmount% DV
Potassium90 mg2%
Glycine0 NP--
Sodium D-Aspartic Acid3000 mg--
L-Ornithine AKG0 NP--
Mucuna Pruriens0 NP--
Testosterone & Nitric Oxide Matrix3750 mg--

Other ingredients: Maltodextrin, Natural & Artificial flavors, Potassium Citrate, Silicon Dioxide, Sucralose, FD&C Red 40, FD&C Blue 1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

ANS

t {Twitter}

f {Facebook}

Precautions

Warning: This product is only intended to be consumed by healthy adults 18 years of age or older.

Before using product, seek advice from a physician if you are unaware of you current health condition or have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, difficulty urinating due to prostate enlargement, or if you are taking a MAO-B inhibitor or any other prescription or over the counter medication. Do not use if you are pregnant, nursing, prone to dehydration or exposed to excessive heat.

Discontinue use and consult your health care professional if sleeplessness, tremors, dizziness, nervousness, headaches, or heart palpitations occur or if you experience any adverse reaction to the product. Discontinue use two weeks prior to surgery. Do not exceed recommended dose.

KEEP OUT OF REACH OF CHILDREN.

ALLERGEN WARNING: Manufactured on equipment which processes products containing milk, eggs, soybeans, wheat, shellfish, fish oil, tree nuts, and peanut flavor.

General Statements

Contents may settle after shipping.

Moisture and humidity can cause clumping and discoloration.

lot #, Exp. date

ELEVATE TESTOSTERONE INCREASE STRENGTH ENHANCE VASCULARITY

{QR Code}

Suggested/Recommended/Usage/Directions

Shake container prior to each use to redistribute ingredients.

SUGGESTED USE: As a dietary supplement, mix 1 serving in 6-12 oz. of cold water 30 minutes prior to exercise. Do not exceed 1 scoop in a 24 hour period. Use for up to 4 weeks with a 2-4 week washout period between cycles. To be used as part of a physical conditioning program. Do not exceed recommended dose. For enhanced results, combine with ANS Methyl Pump and Post BCAA.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Test D-Aspartic Grape by ANS label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Test D-Aspartic Grape label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Test D-Aspartic Grape by ANS

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size8 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Potassium

Interacts with
62 drugs
90 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Testosterone & Nitric Oxide Matrix

3750 mg per serving

Other (inactive) ingredients: Maltodextrin, Natural & Artificial flavors, Potassium Citrate, Silicon Dioxide, Sucralose, FD&C Red 40, FD&C Blue 1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Test D-Aspartic Grape by ANS Drug Interactions

Want to check YOUR meds against Test D-Aspartic Grape?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
407Drugs
17 Major 390 Moderate

Ingredients driving the most interactions

Sodium D-Aspartic Acid 205
Mucuna Pruriens 193
Potassium 62
Glycine 1

Individual Drug Interactions

The ingredients in Test D-Aspartic Grape interact with 407 drugs. Click any drug to see the details.

4 of the 5 ingredients in Test D-Aspartic Grape interact with drugs. Each result below shows which ingredient is responsible. Sodium D-Aspartic Acid Mucuna Pruriens Potassium Glycine

Each ingredient & the kinds of drugs it affects

For each ingredient in Test D-Aspartic Grape with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium D-Aspartic Acid7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium D-Aspartic Acid full monograph & interactions

Mucuna Pruriens8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
Mucuna Pruriens full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Test D-Aspartic Grape, from the product label.

ANS

See all ANS products
Name
ANS(R) ADVANCED NUTRITION SYSTEMS, LLC
City
Greenville
State
SC
ZipCode
29607
Phone Number
1.888.247.5326
Web Address
www.advanced247.com
Pharmacist Counseling Corner

Test D-Aspartic Grape by ANS: Common Questions

Does Test D-Aspartic Grape by ANS interact with any medications?
Yes. Based on its ingredients, Test D-Aspartic Grape has a known interaction with 407 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Test D-Aspartic Grape contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Mucuna pruriens and why is it in this product?
Mucuna pruriens is a plant extract that contains levodopa, a compound affecting dopamine in the brain. It's included here as an active ingredient, though the data we hold show insufficient evidence for most of its proposed uses — including anxiety, Parkinson disease, and muscle pain.
Is this safe to take if I'm pregnant or breastfeeding?
Potassium and sodium from diet are fine in pregnancy and lactation, but supplements need your doctor's okay. Glycine safety data are limited — ask your doctor before using it. Mucuna pruriens is possibly unsafe in pregnancy and should be avoided while breastfeeding because its levodopa content can lower milk supply. Talk with your doctor about your individual situation.
What side effects might I experience?
Common side effects are rare but can include abdominal pain, nausea, diarrhea, and flatulence from the potassium and Mucuna pruriens. In clinical studies using higher doses of Mucuna pruriens, about 3% of people reported insomnia. Rare but serious effects from excess potassium include arrhythmia and low blood pressure. If you notice unusual heartbeat, severe stomach pain, or mood changes, stop and contact your doctor.
Does this product actually work for what it claims?
The evidence is mixed and incomplete. Glycine is possibly effective for schizophrenia, and sodium D-aspartic acid may help cystic fibrosis and amphotericin B kidney damage, but most other claimed uses have insufficient evidence in the data we hold. Ask your doctor whether this is the right choice for your specific health goal.
Why is there so much sodium and potassium in this?
Both are active ingredients here, included for their effects on blood pressure and electrolyte balance. However, because they interact with many medications and high amounts can be risky — especially if you have kidney disease — it's important you review your medications with your pharmacist before starting.
What is L-Ornithine AKG and does it interact with anything?
L-Ornithine AKG is an amino acid derivative included as an active ingredient. We don't hold interaction data for it, so we cannot confirm whether it interacts with medications. Discuss it with your pharmacist if you're on any prescriptions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Test D-Aspartic Grape label
Go deeper

The Full Monographs Behind Test D-Aspartic Grape’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

Test D-Aspartic Grape's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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