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Dietary supplement

TestoPlex Plus Ingredients & Drug Interactions

by XYMOGEN

TestoPlex Plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TestoPlex Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TestoPlex Plus is a dietary supplement by XYMOGEN with 2 active ingredients. Its ingredients are commonly taken for fatigue and low energy, male fertility and testosterone support, general vitality and aging.Based on those ingredients, 333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LJ100, PrimaVie. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TestoPlex Plus by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with TestoPlex Plus by XYMOGEN — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TestoPlex Plus by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

TestoPlex Plus has 2 active ingredients. PrimaVie is a purified form of shilajit, a mineral-rich substance traditionally used in Ayurvedic medicine.

LJ100 is eurycoma longifolia (also called Tongkat Ali), an herbal extract from Southeast Asia. The rest of the capsule is made up of inactive ingredients—the shell, binders, and fillers—which include hypromellose, microcrystalline cellulose, dicalcium phosphate, and silica.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support vitality and general physical well-being.
  • We looked for evidence on: Age-related testosterone deficiency, Athletic performance, Male Infertility, Muscle strength, Sexual desire, Sexual dysfunction — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence supporting TestoPlex Plus's ingredients is limited. For shilajit (PrimaVie), we don't have reliable evidence to rate it for Alzheimer's disease, sexual dysfunction, athletic performance, benign prostate enlargement, or bone density.

For eurycoma longifolia (LJ100), the data shows it may be effective for sexual desire, but it appears ineffective for athletic performance, and evidence is insufficient for back pain, osteoporosis, or diabetes. If you're considering this product for a specific health goal, talk with your pharmacist about what the research actually supports.

The evidence, ingredient by ingredient Shilajit Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Shilajit is generally well tolerated, but you need to use only purified, tested brands because unpurified products may contain heavy metals or other contaminants. Rare side effects include headache, and a few case reports describe allergic reactions (including one severe case of anaphylaxis linked to exercise) and a case of high blood pressure with mineral imbalances during pregnancy.

Eurycoma longifolia is generally well tolerated short-term in studies, but long-term safety isn't well established. If testosterone levels rise above the normal range, there's a risk of related side effects like acne, insulin resistance, and liver problems.

Do not use either ingredient during pregnancy or while breastfeeding—safety data is insufficient or absent for both.

Side effects, ingredient by ingredient Shilajit Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Eurycoma Longifolia, Shilajit.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 333 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start TestoPlex Plus, double-check the following with your pharmacist: antidiabetes drugs (metformin, glibenclamide, and others)—shilajit may lower your blood sugar too much; propranolol (Inderal)—eurycoma longifolia may reduce how well it works; and any medications processed by your liver as CYP1A2, CYP2C19, or CYP2A6 substrates, where eurycoma might raise drug levels. If you're on hormone replacement or testosterone therapy, mention that too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TestoPlex Plus is a two-ingredient supplement with documented interactions, most notably with antidiabetes drugs and propranolol. If you take any prescription medications, especially for blood sugar control or heart health, check your specific drugs with the tool below before starting.

The evidence for what this product actually does is thin. Talk to your pharmacist about whether it makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TestoPlex Plus, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149000288
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 303853
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TestoPlex Plus by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
871149000288
IngredientAmount% DV
PrimaVie500 mg--
LJ100200 mg--

Other ingredients: Hypromellose, Water, Microcrystalline Cellulose, Dicalcium Phosphate Dihydrate, Ascorbyl Palmitate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: Take two capsules in the morning, or as directed by your healthcare professional.

Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged. The labeling on this product does not comply with California's Proposition 65. Therefore, this product may not be sold in California.

STORAGE: Keep closed in a cool, dry place out of reach of children.

Formula

TestoPlex Plus features two safe, clinically-tested, standardized, and patented ingredients designed to support vitality and general physical and mental well-being in men and women. Numerous studies have demonstrated that PrimaVie shilajit and LJ100 Eurycoma longifolia support healthy androgen biosynthesis, which includes modulating the influence of sex hormone-binding globulin.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORAGE: Keep closed in a cool, dry place out of reach of children.

Formulation

FORMULATED TO EXCLUDE: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Vegetarian caps

Supports vitality, virility, and vigor

Brand IP Statement(s)

S1. PrimaVie is a registered trademark of Natreon, Inc. and is protected under U.S. patents 6,969,612 and 6,440,712. S2. LJ100 is a registered trademark of HP Ingredients. Bioactive Fraction of Eurycoma Longifolia is protected by Worldwide patent WO/02/17946 A1 and U.S. patent 7,132,117.

Copyright 2023 XYMOGEN

Xymogen Exclusive professional formulas

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Vegetarian caps ePV (ePedigree Verification)

GMP compliant third-party verified

General Statements

Scan to learn more! This package is completely recyclable

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See for yourself

TestoPlex Plus by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TestoPlex Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TestoPlex Plus by XYMOGEN

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

PrimaVie

Interacts with
86 drugs
500 mg per serving Form: Shilajit

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and v...

PrimaVie monograph & interactions

LJ100

Interacts with
248 drugs
200 mg per serving Form: Eurycoma longifolia Root Extract

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

LJ100 monograph & interactions

Other (inactive) ingredients: Hypromellose, Water, Microcrystalline Cellulose, Dicalcium Phosphate Dihydrate, Ascorbyl Palmitate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

TestoPlex Plus by XYMOGEN Drug Interactions

Want to check YOUR meds against TestoPlex Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
333Drugs
89 Moderate 244 Minor

Ingredients driving the most interactions

LJ100 248
PrimaVie 86

Individual Drug Interactions

The ingredients in TestoPlex Plus interact with 333 drugs. Click any drug to see the details.

2 of the 2 ingredients in TestoPlex Plus interact with drugs. Each result below shows which ingredient is responsible. LJ100 PrimaVie

Each ingredient & the kinds of drugs it affects

For each ingredient in TestoPlex Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

LJ1005 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
LJ100 full monograph & interactions

PrimaVie1 drug type · 86 drugs

Antidiabetes Drugs

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
PrimaVie full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TestoPlex Plus, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

TestoPlex Plus by XYMOGEN: Common Questions

Does TestoPlex Plus by XYMOGEN interact with any medications?
Yes. Based on its ingredients, TestoPlex Plus has a known interaction with 333 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TestoPlex Plus contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take TestoPlex Plus while I'm on metformin for diabetes?
Not without talking to your doctor first. Shilajit in this product can make metformin work stronger and increase your risk of low blood sugar. You'd need your blood sugar monitored closely and possibly a dose adjustment.
What is shilajit, and why is the label called PrimaVie?
Shilajit is a mineral-rich substance from traditional Ayurvedic medicine. PrimaVie is a purified, tested form of it. The label says purified because unpurified shilajit can contain heavy metals or other contaminants you want to avoid.
Is it safe to take this if I'm pregnant or breastfeeding?
No. Both ingredients should be avoided during pregnancy due to insufficient safety data and possible hormone effects. Avoid during breastfeeding too—there's not enough reliable information to know if it's safe.
What does eurycoma longifolia (LJ100) actually do?
Research suggests it may help with sexual desire, so that's the main claim backed by evidence. It doesn't appear to help athletic performance, and we don't have solid data for back pain, bone strength, or blood sugar control.
Has anyone had side effects from shilajit?
It's generally well tolerated, but headaches are reported rarely. A few case reports describe allergic reactions, including one severe case with anaphylaxis tied to taking a higher dose with exercise. One case of high blood pressure with mineral imbalances was reported during pregnancy, though shilajit's exact role wasn't confirmed.
Should I be concerned about long-term use?
Eurycoma longifolia's long-term safety isn't well studied. And if it raises your testosterone levels above normal, there's a risk of side effects like acne, insulin resistance, and liver problems. Stick with what clinical research has tested, and talk to your pharmacist about how long you plan to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TestoPlex Plus label
Go deeper

The Full Monographs Behind TestoPlex Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Shilajit

Interacts with 86 drugs

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and m...

Read the full Shilajit monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

TestoPlex Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Shilajit 8 references
  1. Sadeghi SMH, Hosseini Khameneh SM, Khodadoost M, et al. Efficacy of momiai in tibia fracture repair: A randomized double-blinded placebo-controlled clinical trial. J Altern Complement Med 2020;26(6):521-528.
  2. Losa F, Deidda M, Firinu D, Martino MLD, Barca MP, Giacco SD. Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor: A case report. World J Clin Cases 2019;7(5):623-627. PubMed
  3. Biswas TK, Pandit S, Mondal S, et al. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia 2010;42(1):48-56. PubMed
  4. Stavropoulos K, Sotiriadis A, Patoulias D, et al. Pseudohyperaldosteronism due to mumijo consumption during pregnancy: a licorice-like syndrome. Gynecol Endocrinol 2018;34(12):1019-1021. PubMed
  5. Ghezelbash B, Shahrokhi N, Khaksari M, Ghaderi-Pakdel F, Asadikaram G. Hepatoprotective effects of shilajit on high fat-diet induced non-alcoholic fatty liver disease (NAFLD) in rats. Horm Mol Biol Clin Investig 2020;41(1):/j/hmbci. PubMed
  6. Ghezelbash B, Shahrokhi N, Khaksari M, Asadikaram G, Shahrokhi M, Shirazpour S. Protective roles of shilajit in modulating resistin, adiponectin, and cytokines in rats with non-alcoholic fatty liver disease. Chin J Integr Med 2022;28(6):531-537. PubMed
  7. Jafari M, Forootanfar H, Ameri A, et al. Antioxidant, cytotoxic and hyperalgesia-suppressing activity of a native Shilajit obtained from Bahr Aseman mountains. Pak J Pharm Sci 2019;32(5):2167-2173. DOI
  8. Trivedi NA, Mazumdar B, Bhatt JD, Hemavathi KG. Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats. Ind. J. Pharmacol. 2004; 36(6):373-376.

See these in context on the Shilajit monograph →

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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