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Dietary supplement

TitanFlow Ingredients & Drug Interactions

by Zenith Labs

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

TitanFlow is a dietary supplement by Zenith Labs with 5 active ingredients. Its ingredients are commonly taken for high cholesterol, enlarged prostate (bph), heart health.Based on those ingredients, 284 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Broccoli Sprout Extract, Lycopene, Pumpkin Seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of TitanFlow by Zenith Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

TitanFlow contains five active ingredients. Beta-sitosterol and pygeum africanum bark extract are plant-derived compounds used to support prostate health.

Broccoli sprout extract provides glucosinolates (plant compounds that affect how your liver metabolizes drugs), and pumpkin seed oil has traditionally been used for urinary and prostate support. Lycopene is a red pigment from tomatoes linked to prostate health.

The product also contains inactive ingredients—rice flour, silicon dioxide, magnesium stearate, and gelatin—which serve as fillers and capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Prostate health and urinary function.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Overactive bladder, Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Urinary tract infections (UTIs), Prostate support, Lower urinary tract symptoms — and 1 related terms.
  • The strongest evidence on file: Pygeum is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Beta-sitosterol is rated "Likely Effective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH).

Beta-sitosterol is likely effective for benign prostatic hyperplasia (BPH, or enlarged prostate) and possibly effective for high cholesterol and heart disease. Pygeum is also likely effective for BPH, though it's not well studied for other conditions like Alzheimer's or sexual function.

Pumpkin seed oil is possibly effective for BPH. Lycopene is possibly effective for prostate cancer but possibly ineffective for bladder cancer and diabetes.

Broccoli sprout extract is possibly effective for colorectal cancer, but evidence is insufficient for most other conditions.

The evidence, ingredient by ingredient Beta-sitosterol Pygeum Broccoli Pumpkin Lycopene

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-sitosterol, pumpkin seed oil, and lycopene are generally well tolerated overall. The most common side effects are digestive—constipation, diarrhea, gas, indigestion, and nausea—reported with beta-sitosterol and pumpkin seed oil.

Broccoli sprout extract may cause loose stools, diarrhea, abdominal pain, or cramping, especially at higher doses. A rare case of pancreatitis has been reported with beta-sitosterol, though the link is uncertain.

Pregnancy and breastfeeding data are limited: beta-sitosterol and pumpkin seed oil should be avoided in pregnancy and breastfeeding due to insufficient safety information, and lycopene supplements are not well studied during these periods. Broccoli sprout extract is likely safe in pregnancy, but concentrated supplements haven't been thoroughly studied.

Side effects, ingredient by ingredient Beta-sitosterol Pygeum Broccoli Pumpkin Lycopene

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Lycopene, Pumpkin, Broccoli.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 284 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against broccoli sprout extract (which can weaken drugs broken down by CYP1A2 and CYP2A6 enzymes—a Moderate concern), pumpkin seed oil (if you take lithium, Moderate severity), and lycopene (with blood thinners or antiplatelet drugs, Moderate severity). No interactions are documented for beta-sitosterol or pygeum in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TitanFlow is aimed at prostate health with ingredients that have some evidence for BPH. If you take any liver-metabolized drugs, blood thinners, or lithium, run your medication list through the checker below before starting.

Talk to your pharmacist or doctor if you're pregnant, breastfeeding, or have any digestive concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TitanFlow, straight from the product label.

Brand Zenith Labs
Barcode (UPC) X00438XSUZ
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 326188
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Seniors/Mature (>50 Years) - Men ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TitanFlow by Zenith Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
X00438XSUZ
IngredientAmount% DV
Beta-Sitosterol30 mg--
Pygeum africanum Bark Extract100 mg--
Broccoli Sprout Extract50 mg--
Pumpkin Seed Oil500 mg--
Lycopene37.5 mg--

Other ingredients: Rice Flour, Silicon Dioxide, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take two (2) capsules once a day.

Precautions

Caution/Warning: Do not exceed recommended dose.

Not for use for those under the age of 18 or pregnant or nursing mothers. Consult with a physician prior to use especially if you are taking a medication or have a medical condition.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Storage: Store this product in a cool dry place below 30 degrees C (86 degrees F).

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Prostate

FDA Statement of Identity

Dietary Supplement

General Statements

Doctor Formulated

See for yourself

TitanFlow by Zenith Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in TitanFlow by Zenith Labs

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beta-Sitosterol

No known
interactions
30 mg per serving

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Eviden...

Beta-Sitosterol monograph & interactions

Pygeum africanum Bark Extract

No known
interactions
100 mg per serving

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...

Pygeum africanum Bark Extract monograph & interactions

Broccoli Sprout Extract

Interacts with
187 drugs
50 mg per serving

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

Broccoli Sprout Extract monograph & interactions

Pumpkin Seed Oil

Interacts with
1 drug
500 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin Seed Oil monograph & interactions

Lycopene

Interacts with
122 drugs
37.5 mg per serving Form: Tomato

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Other (inactive) ingredients: Rice Flour, Silicon Dioxide, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

TitanFlow by Zenith Labs Drug Interactions

Want to check YOUR meds against TitanFlow?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
284Drugs
284 Moderate

Ingredients driving the most interactions

Lycopene 122

Each ingredient & the kinds of drugs it affects

For each ingredient in TitanFlow with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Broccoli Sprout Extract2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D

Pumpkin Seed Oil1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for TitanFlow, from the product label.

Zenith Labs

See all Zenith Labs products
Name
Zenith Labs
Street Address
19655 E 35th Drive, Suite 100
City
Aurora
State
CO
ZipCode
80011
Phone Number
800-928-1184
Web Address
ZenithLabs.com
Pharmacist Counseling Corner

TitanFlow by Zenith Labs: Common Questions

Does TitanFlow by Zenith Labs interact with any medications?
Yes. Based on its ingredients, TitanFlow has a known interaction with 284 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TitanFlow contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will TitanFlow actually help my prostate symptoms?
Beta-sitosterol and pygeum in this product are both likely effective for BPH symptoms. Pumpkin seed oil is possibly effective. That said, prostate health is individual—talk to your doctor about whether this fits your situation and whether you need other treatment too.
What are the most common side effects I might experience?
Digestive upset is the main concern: constipation, diarrhea, gas, indigestion, nausea, or abdominal discomfort. These are usually mild and tend to happen more at higher doses. If you have loose stools or cramping, it may be worth starting with a lower dose or talking to us.
Can I take this if I'm pregnant or breastfeeding?
No, not safely. Beta-sitosterol, pumpkin seed oil, and lycopene don't have enough safety data during pregnancy or breastfeeding, so they should be avoided. Broccoli sprout extract is likely safe in pregnancy, but the product as a whole isn't recommended. Talk to your OB or pharmacist if you need prostate support while pregnant or nursing.
Why does broccoli in this product matter for my medications?
Broccoli sprout extract contains compounds that speed up how your liver breaks down certain drugs, potentially making them less effective. If you take medications metabolized by your liver—especially for heart rhythm, anxiety, or pain—you need to check with us before adding this product.
I take lithium for my mood. Is this safe?
Not without talking to your doctor first. Pumpkin seed oil in TitanFlow may increase lithium levels in your blood, which could be unsafe. Your lithium dose might need to be adjusted if you start this supplement. Check with your prescriber or pharmacist before starting.
What is lycopene and why is it in this product?
Lycopene is a red pigment found in tomatoes. It's in TitanFlow because it's possibly effective for prostate cancer. If you're on blood thinners or antiplatelet drugs, lycopene theoretically raises your bleeding risk, so use the drug checker to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TitanFlow is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TitanFlow label
Go deeper

The Full Monographs Behind TitanFlow’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

TitanFlow's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-sitosterol 7 references
  1. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
  3. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 1999;83:976-83. PubMed
  4. Oster P, Schlierf G, Heuck CC, et al. [Sitosterol in familial hyperlipoproteinemia type II. A randomized, double-blind, cross-over study]. Dtsch Med Wochenschr 1976;101:1308-11.
  5. Becker M, Staab D, Von Bergman K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 1992;89:138-42. DOI
  6. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  7. Lorenze A, Hsueh W, Nasr J. Beta-sitosterol-induced acute pancreatitis: A case report and review of the literature. Cureus. 2020;12(3):e7407. PubMed

See these in context on the Beta-sitosterol monograph →

Pygeum 3 references
  1. Ishani A, MacDonald R, Nelson D, et al. Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis. Am J Med 2000;109:654-64.. PubMed
  2. Wilt T, Ishani A, Mac Donald R, et al. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev 2002;CD001044.. PubMed
  3. Andro M and Riffaud J. Pygeum africanum extract for the treatment of patients with benign prostatic hyperplasia: a review of 25 years of published experience. Curr Ther Res 1995;56(8):796-817. DOI

See these in context on the Pygeum monograph →

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
  8. Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
  9. Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
  10. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

See these in context on the Lycopene monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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