Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Tri Sugar Shield Ingredients & Drug Interactions

by Life Extension

Tri Sugar Shield label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tri Sugar Shield against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tri Sugar Shield is a dietary supplement by Life Extension with 3 active ingredients. Its ingredients are commonly taken for gluten-free food source, blood sugar support, heart and cholesterol health.Based on those ingredients, 87 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are White Mulberry extract, Phloridzin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tri Sugar Shield by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Tri Sugar Shield by Life Extension — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tri Sugar Shield by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Sorghum bran (Sorghum bicolor) extract” is listed as a grouped ingredient — the label gives one combined amount (300 mg) without saying how much of each component you get.
  • “White Mulberry extract” is listed as a grouped ingredient — the label gives one combined amount (150 mg) without saying how much of each component you get.

Tri Sugar Shield contains three active ingredients chosen for blood sugar support. The product includes phlorizin, an extract compound that works on kidney sugar transporters; 1-deoxynojirimycin and proanthocyanidins; and extracts from sorghum bran and white mulberry, each of which contributes multiple active components.

The capsules also contain inactive ingredients—vegetable cellulose, microcrystalline cellulose, maltodextrin, silica, and stearic acid—that serve as binders and fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: support healthy blood sugar levels.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), postprandial glucose control, metabolic health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We don't have effectiveness data on file for the ingredients in this product. While animal research shows phlorizin can lower blood glucose, human trial data for phlorizin supplements aren't available in our records.

The same goes for proanthocyanidins, 1-deoxynojirimycin, sorghum bran, and white mulberry—their effectiveness in people isn't established in the data we hold.

The evidence, ingredient by ingredient Sorghum White Mulberry Phlorizin

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for phlorizin taken as a supplement are very limited. The safety notes advise against phlorizin in pregnancy because reliable data don't exist, and the same goes for breastfeeding—there's no safety information, so it's best avoided if you're nursing.

For the other active ingredients in this product, we don't have adverse effect or safety data on file, so we can't tell you what to expect.

Side effects, ingredient by ingredient Sorghum White Mulberry Phlorizin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phlorizin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antidiabetes drugs before you start—phlorizin has a Moderate interaction risk because it could theoretically add to their blood-sugar-lowering effect. We cannot evaluate the interaction risk of the other active ingredients, so run your complete medication list through the search tool below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you take antidiabetes medication, talk to your pharmacist before starting Tri Sugar Shield—phlorizin might lower your blood sugar further. Because we can't fully check most of the ingredients in this product and human safety data are sparse, a conversation with your healthcare provider makes sense, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tri Sugar Shield, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870180364
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232033
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tri Sugar Shield by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870180364
IngredientAmount% DV
Proanthocyanidins270 mg--
Sorghum bran (Sorghum bicolor) extract300 mg--
White Mulberry extract150 mg--
1-Deoxynojirimycin7.5 mg--
Phloridzin50 mg--

Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Maltodextrin, Silica, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) capsule twice daily immediately before the heaviest carbohydrate or sugar containing meals/drinks, or as recommended by a healthcare practitioner.

Precautions

Caution: If you are taking blood glucose lowering medication, consult your healthcare provider before taking this product.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Non GMO LE Certified

Formulation

Non GMO LE Certified

Triple action shield from simple carbohydrates

FDA Statement of Identity

Dietary Supplement

Storage

Store tightly closed in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tri Sugar Shield by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tri Sugar Shield label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tri Sugar Shield by Life Extension

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sorghum bran (Sorghum bicolor) extract

No known
interactions
300 mg per serving

Sorghum is a nutritious, naturally gluten-free cereal grain rich in fiber and plant antioxidants, and it is mainly valued as a whole food rather than...

Sorghum bran (Sorghum bicolor) extract monograph & interactions
  • › Proanthocyanidins

White Mulberry extract

Interacts with
87 drugs
150 mg per serving

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is gen...

White Mulberry extract monograph & interactions
  • › 1-Deoxynojirimycin

Phloridzin

Interacts with
86 drugs
50 mg per serving Form: Apple extract

Phlorizin is a natural plant compound (a dihydrochalcone) found in apple tree bark and other plants that has been studied mostly in the laboratory for...

Phloridzin monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Maltodextrin, Silica, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tri Sugar Shield by Life Extension Drug Interactions

Want to check YOUR meds against Tri Sugar Shield?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
87Drugs
87 Moderate

Ingredients driving the most interactions

White Mulberry extract 87
Phloridzin 86

Individual Drug Interactions

The ingredients in Tri Sugar Shield interact with 87 drugs. Click any drug to see the details.

2 of the 3 ingredients in Tri Sugar Shield interact with drugs. Each result below shows which ingredient is responsible. White Mulberry extract Phloridzin

Each ingredient & the kinds of drugs it affects

For each ingredient in Tri Sugar Shield with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

White Mulberry extract2 drug types · 87 drugs

Antidiabetes Drugs

Theoretically, white mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Clinical research shows that white mulberry leaf can lower blood glucose levels. Advise patients to monitor glucose levels closely.

Likelihood Possible Evidence D
Organic Cation Transporter 2 (Oct2) Substrates

Theoretically, white mulberry leaf might slow the elimination and increase the adverse effects of drugs which are OCT2 substrates.
Animal research shows that coadministration of white mulberry leaf extract with metformin, an OCT2 substrate, slows the renal elimination of metformin via inhibition of OCT2 activity. OCT2 is expressed in the kidneys and is responsible for transporting cationic drugs into tubular epithelial cells in order to be excreted in the urine.

Likelihood Possible Evidence D
White Mulberry extract full monograph & interactions

Phloridzin1 drug type · 86 drugs

Antidiabetes Drugs

Phlorizin is a potent, nonselective inhibitor of SGLT1 and SGLT2. It has been shown to reduce blood glucose levels in animal research. Theoretically, phlorizin might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. However, the likelihood of this effect is unclear due to the poor bioavailability and rapid degradation of phlorizin. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence D
Phloridzin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tri Sugar Shield, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Tri Sugar Shield by Life Extension: Common Questions

Does Tri Sugar Shield by Life Extension interact with any medications?
Yes. Based on its ingredients, Tri Sugar Shield has a known interaction with 87 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tri Sugar Shield contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phlorizin do in this formula?
Phlorizin is a compound that blocks certain transporters in your kidneys that normally filter blood sugar back into your body. In animal studies it has lowered blood glucose levels, though human research is limited and absorption of the supplement form is poor.
Is it safe to take this if I'm pregnant or breastfeeding?
Safety data for phlorizin in pregnancy and breastfeeding are too limited to recommend it. The safety information we have advises against use in both cases. Talk to your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or nursing.
Are there any side effects I should know about?
We don't have data on adverse effects for the ingredients in this product. Human safety information for phlorizin supplements is very limited, so side effect data aren't well established.
Can I take this with my diabetes medication?
Phlorizin may theoretically add to the blood-sugar-lowering effect of diabetes drugs and raise the risk of low blood sugar. Use the search tool on this page to check your specific medication, then talk to your pharmacist or doctor before you start.
Why can't you check all the ingredients?
We don't hold monograph data for proanthocyanidins or 1-deoxynojirimycin, and the sorghum bran and white mulberry extracts are blends of multiple components that aren't individually available in our database. That limits how much we can tell you about their interactions and safety.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tri Sugar Shield is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tri Sugar Shield label
Go deeper

The Full Monographs Behind Tri Sugar Shield’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sorghum

Sorghum is a nutritious, naturally gluten-free cereal grain rich in fiber and plant antioxidants, and it is mainly valued as a whole food rather than a proven medicine. While its nutrients m...

Read the full Sorghum monograph → Herb & supplement monograph

White Mulberry

Interacts with 87 drugs

White mulberry leaf is most studied for helping blunt the rise in blood sugar after meals, but the human evidence is limited and not strong. It is generally well tolerated as a food and tea,...

Read the full White Mulberry monograph → Herb & supplement monograph

Phlorizin

Interacts with 86 drugs

Phlorizin is a natural plant compound (a dihydrochalcone) found in apple tree bark and other plants that has been studied mostly in the laboratory for its effects on blood sugar handling. Th...

Read the full Phlorizin monograph →
Sources

Sources & How We Checked

Tri Sugar Shield's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sorghum 3 references
  1. Ayuba GI, Jensen GS, Benson KF, Okubena AM, Okubena O. Clinical efficacy of a West African sorghum bicolor-based traditional herbal preparation Jobelyn shows increased hemoglobin and CD4+ T-lymphocyte counts in HIV-positive patients. J Altern Complement M
  2. Tayo AO, Dosunmu AO, Akinola IO, et al. An open-label, randomized, parallel-group comparative study of the efficacy of sorghum bicolor extract in preoperative anemia. Nutrition. 2017;33:113-117. PubMed
  3. Anunciação PC, Cardoso LM, Alfenas RCG, et al. Extruded sorghum consumption associated with a caloric restricted diet reduces body fat in overweight men: a randomized controlled trial. Food Res Int 2019;119:693-700. PubMed

See these in context on the Sorghum monograph →

White Mulberry 6 references
  1. Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta 2001;314:47-53. PubMed
  2. Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care 2007;30:1272-4. PubMed
  3. Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem 2007;55:5869-74. PubMed
  4. Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. 2020;12(1):49. PubMed
  5. Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. 2020;49:102292. PubMed
  6. Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) 2021;18(1):41. PubMed

See these in context on the White Mulberry monograph →

Phlorizin 1 reference
  1. Chao EC, Henry RR. SGLT2 inhibition--a novel strategy for diabetes treatment. Nat Rev Drug Discov. 2010;9(7):551-9. PubMed

See these in context on the Phlorizin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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