Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

TriActive Biotics Ingredients & Drug Interactions

by Essential Source

TriActive Biotics label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TriActive Biotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TriActive Biotics is a dietary supplement by Essential Source with 2 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TriActive Biotics by Essential Source

Ask about any prescription or over-the-counter medication and we check it for interactions with TriActive Biotics by Essential Source — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TriActive Biotics by Essential Source

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 15 active ingredients.
  • “Prebiotic” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Probiotic” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (150 mg) without saying how much of each component you get.

TriActive Biotics contains 15 active ingredients—a mix of live probiotic bacteria and prebiotic fiber designed to support digestive health. The probiotics include well-known strains like Lactobacillus acidophilus, Bifidobacterium species, and others that naturally live in your gut.

Fructooligosaccharides (a soluble fiber) serves as prebiotic food to help these beneficial bacteria thrive. The remaining inactive ingredients are standard capsule materials and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and gut microbiome balance.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).

The evidence here is mixed and often limited. Lactobacillus acidophilus, Bifidobacterium bifidum, and Bacillus coagulans are rated possibly effective for irritable bowel syndrome (IBS) and antibiotic-associated diarrhea.

L. acidophilus is also possibly effective for bacterial vaginosis and H. pylori infection. For most other conditions listed—constipation, diabetes, hay fever, asthma, and many others—the evidence for these strains is insufficient to say whether they work.

Fructooligosaccharides similarly lacks reliable evidence for constipation, cholesterol, or diabetes. In short, if you're thinking about this for IBS or to prevent diarrhea from antibiotics, there's some reason to consider it; for other uses, the data doesn't support a strong claim.

The evidence, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these probiotics are generally well tolerated in healthy adults. Fructooligosaccharides can cause gas, bloating, and abdominal pain—especially at higher doses—though studies show these effects are mild under 10 grams daily.

The main caution is for people with weakened immune systems (from illness, medications, or medical devices like central lines), preterm infants, and those who are severely ill: in rare cases, live probiotic organisms have caused blood infections (bacteremia and sepsis) in these groups. Healthy people with intact immune systems have not shown this risk in the data.

Gastrointestinal side effects like bloating, flatulence, and abdominal discomfort can occur but are uncommon. One clinical trial reported rash and itching in a small number of participants, though it's unclear if the probiotics were responsible.

Side effects, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bacillus Coagulans, Bifidobacterium Bifidum, Bifidobacterium Longum, Lactobacillus Delbrueckii.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medications to double-check before you start. Several probiotic strains in here interact with antibiotics at a Moderate level—the antibiotics can kill the live organisms and make this supplement less effective.

Talk to your pharmacist about timing: you'll typically want to space them several hours apart. Use the medication checker below to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TriActive Biotics is a multi-strain probiotic suited for people interested in gut health, especially those considering support for IBS or antibiotic-related diarrhea. If you take antibiotics, time this supplement a few hours apart from them so they don't cancel each other out.

If you have a weakened immune system, are critically ill, or have a central line or similar device, talk to your doctor before starting. For otherwise healthy adults, it's generally well tolerated—watch out for some gas or bloating, especially at first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 31, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TriActive Biotics, straight from the product label.

Brand Essential Source
Barcode (UPC) 748252445414
Net contents 0 Not Present
Market status On market
Date entered into DSLD Aug 31, 2018
DSLD ID 176062
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TriActive Biotics by Essential Source, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
Servings per container
30
UPC/BARCODE
748252445414
IngredientAmount% DV
Streptococcus thermophilus0 NP--
Prebiotic0 NP--
Probiotic0 NP--
Fructooligosaccharides53 mg--
Probiotic Blend150 mg--
Lb. acidophilus (La-14)0 NP--
Bif. longum (BI-05)0 NP--
Lb. plantarum (Lp-115)0 NP--
Lb. bulgaricus (Lb-87)0 NP--
Bif. infantis (Bi-26)0 NP--
Lb. casei (Lc-11)0 NP--
Lb. salivarius (Ls-33)0 NP--
Lb. rhamnosus (Lr-32)0 NP--
Bif. bifidum (Bb-06)0 NP--
Lb. paracasei (Lpc-37)0 NP--
Lb. sporogenes0 NP--
Lb. reuteri (E1E)0 NP--
Lb. acidophilus (DDS-1)0 NP--

Other ingredients: Glycerine, Microcrystalline Cellulose, Vegetable Capsule, Calcium Laurate, Chlorophyllin, Silicon Dioxide, Vegetable Cellulose, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Advanced delivery system 3 stage delivery 14 different strains & strengths 6 billion live cultures per capsule

We're so sure Tri Active Biotics will bring you great results that we'll reward you for taking if for three consecutive months! Just send us 3 proofs of purchase with $6.95 to cover shipping and handling, and we send you a 4th box for free! It's that simple! ...Just send it to Essential Source 625 W. Deer Valley Rd. STE 103-152, Phoenix, AZ, 85027

What is the Tri Active difference?.... Method for CFU multiplication TriActive Biotics, features capsule-in-capsule technology which is superior to other brands. Our prebiotic releases in the gut where it flourishes, unlike competing delayed release (D/R) caps. Probiotics release in the prebiotic filled small intestine for superior nutrient absorption. 14 strains of probiotics are used covering all aspects of probiotic needs. This ensures consumers get the full spectrum of health benefits. This product was manufactured in a GMP approved facility.

The efficacy of this product has not been confirmed by clinical research, and traditional uses do not establish that this product will achieve any claimed result.

Innovative 3 stage delivery Immune support/digestive health

Moisture defense Probiotic

30 day supply

How our advanced multi-step delivery works! Stage 1 - Prebiotic Release TriActive releases a liquid prebiotic into the stomach where it balances the pH in the gut, discourages the growth of unfriendly bacteria, and establishes a path of food for the probiotic. Stage 2 - Prebiotic Protection The inner capsule of TriActive's probiotics is protected from degradation and travels past the stomach. Stage 3 - Probiotic Multiplication TriActive probiotic is released into the intestine where the prebiotic has established a pathway of food for it to flourish. This creates and enviornment that allows for CFU multiplication, providing a higher level of benefit. Featuring Advanced Probiotics Probiotics are organisms such as bacteria or yeast that are believed to improve health. Researchers believe that some digestive disorders happen when the balance of friendly bacteria in the intestines becomes disturbed. Probiotics can improve intestinal function and maintain the integrity of the lining of the intestines. These friendly organisms make up 70% of the human immune system.

Suggested/Recommended/Usage/Directions

TriActive Biotics Directions: Take one capsule daily. Best taken on empty stomach.

Storage

Store in a cool dry place. Keep refrigerated for extended stability.

Formulation

Contains No: Soy, milk, egg, wheat, gluten, peanuts/tree nuts, animal byproduct, or artificial colors. Non-GMO

Precautions

Warning: Keep out of reach of children.

Women who are pregnant or nursing should consult their physician before taking this product.

Seals/Symbols

100% Non-GMO

GMP Good Manufacturing Practice Consistent quality

Made in USA

Brand IP Statement(s)

Take the TriActive Biotics challenge!

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to prevent, treat or cure any disease.

Formula

Prebiotic (FOS)

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TriActive Biotics by Essential Source label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TriActive Biotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TriActive Biotics by Essential Source

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Prebiotic

0 NP per serving

Probiotic

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic monograph & interactions

Other (inactive) ingredients: Glycerine, Microcrystalline Cellulose, Vegetable Capsule, Calcium Laurate, Chlorophyllin, Silicon Dioxide, Vegetable Cellulose, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

TriActive Biotics by Essential Source Drug Interactions

Want to check YOUR meds against TriActive Biotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic 182

Individual Drug Interactions

The ingredients in TriActive Biotics interact with 182 drugs. Click any drug to see the details.

1 of the 2 ingredients in TriActive Biotics interact with drugs. Each result below shows which ingredient is responsible. Probiotic

Each ingredient & the kinds of drugs it affects

For each ingredient in TriActive Biotics with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TriActive Biotics, from the product label.

Essential Source

See all Essential Source products
Name
Essential Source, Inc.
Street Address
625 Deer Valley Road Suite 103-152
City
Phoenix
State
AZ
ZipCode
85027
Phone Number
(877) 879-9966
Web Address
www.EssentialSource.net
Pharmacist Counseling Corner

TriActive Biotics by Essential Source: Common Questions

Does TriActive Biotics by Essential Source interact with any medications?
Yes. Based on its ingredients, TriActive Biotics has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TriActive Biotics contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotics?
Not at the same time. The antibiotic will kill the live bacteria in this product and make it less effective. Ask your pharmacist to help you space them out—usually a few hours apart works. If you're taking the product to prevent antibiotic-related diarrhea, starting it after your antibiotic course ends is another option.
Will this help my IBS?
A couple of the strains in here—Lactobacillus acidophilus and Bifidobacterium bifidum—are rated possibly effective for IBS based on available evidence. That doesn't mean it'll work for you, but there's enough reason to consider trying it. Results vary person to person.
Does it have any fillers or binders I should know about?
Yes, the capsule itself contains microcrystalline cellulose, vegetable cellulose, glycerine, and a few other inactive ingredients to hold it together and keep it stable. If you have sensitivities to any of those, let me know and we can look at the list.
What's the difference between probiotics and prebiotics in this formula?
Probiotics are the live beneficial bacteria—the Lactobacillus and Bifidobacterium strains. Prebiotics (the fructooligosaccharides) are a type of fiber that feeds those bacteria so they can grow and do their job in your gut.
Could this cause gas or bloating?
Yes, especially the fructooligosaccharides can cause gas, bloating, and abdominal discomfort, particularly when you first start it. The studies show these effects are usually mild, but start with a low dose and build up if you want to minimize them.
Is it safe during pregnancy or breastfeeding?
We don't have complete safety data for pregnancy or breastfeeding for all the strains in here. Probiotics from food are generally thought to be fine, but supplement-level doses haven't been well studied. Talk to your doctor or midwife before starting if you're pregnant or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TriActive Biotics label
Go deeper

The Full Monographs Behind TriActive Biotics’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

TriActive Biotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 99 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Streptococcus Thermophilus 21 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Dolatkhah N, Hajifaraji M, Abbasalizadeh F, Aghamohammadzadeh N, Mehrabi Y, Abbasi MM. Is there a value for probiotic supplements in gestational diabetes mellitus? A randomized clinical trial. J Health Popul Nutr. 2015;33:25. PubMed
  12. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  13. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  14. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  15. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  16. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  17. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  18. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  19. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  20. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  21. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Streptococcus Thermophilus monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
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See these in context on the Bifidobacterium Longum monograph →

Lactobacillus Delbrueckii 9 references
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See these in context on the Lactobacillus Delbrueckii monograph →

Bifidobacterium Bifidum 7 references
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  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bacillus Coagulans 20 references
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  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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