Interactions on record — worth a quick check against your medications. Based on 7 of 21 ingredients. Check your meds →
Dietary supplement

TriActive Biotics Daily Care Ingredients & Drug Interactions

by Essential Source

TriActive Biotics Daily Care label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TriActive Biotics Daily Care against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TriActive Biotics Daily Care is a dietary supplement by Essential Source with 21 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve BR03, Lactobacillus acidophilus LA02, Bifidobacterium bifidum BB01. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against TriActive Biotics Daily Care by Essential Source

Ask about any prescription or over-the-counter medication and we check it for interactions with TriActive Biotics Daily Care by Essential Source — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of TriActive Biotics Daily Care by Essential Source

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 21 active ingredients.
  • “FFe4 Fermented Fungal Enzyme Blend” is a proprietary blend — the label gives one combined amount (150 mg) without saying how much of each component you get.
  • “Microencapsulated Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

TriActive Biotics Daily Care is a 21-ingredient powder with multiple strains of live beneficial bacteria (probiotics) plus digestive enzymes. The active ingredients are the probiotic bacteria — Lactobacillus and Bifidobacterium strains plus Streptococcus thermophilus — along with three fungal enzymes (Protease, Amylase, and Lactase) to help break down food.

The product also contains a prebiotic to feed the good bacteria. The inactive ingredients include xanthan gum, xylitol, inulin, natural flavor, medium chain triglycerides, malic acid, rebaudioside A, and glycerol ester — these are fillers and binders that help deliver and stabilize the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune support and digestive health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Colic, Clostridioides difficile infection, Common cold, Constipation — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Helicobacter pylori, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for this product's probiotic strains is mixed. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections. Lactobacillus plantarum and several other strains have insufficient evidence on file for most conditions we checked.

Lactase (the enzyme for lactose) is effective for lactose intolerance. The other enzymes and most of the probiotic strains lack established effectiveness data in our records for the conditions we looked up.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lactase Bifidobacterium Breve Lactobacillus Acidophilus Bifidobacterium Bifidum Bifidobacterium Longum Streptococcus Thermophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in this product are generally well tolerated by healthy adults. However, a few cautions apply: Protease should be avoided during pregnancy unless prescribed, and breastfeeding use isn't recommended without medical advice.

Lactase is likely low risk in pregnancy but check with your doctor first; breastfeeding use also requires consultation. The four probiotic strains with interaction data (Bifidobacterium breve, L. acidophilus, B. bifidum, and B. longum) carry a general caution for people with weakened immune systems — if you're critically ill, severely immunocompromised, a preterm infant, or have indwelling catheters, talk to your doctor before starting.

Rare allergic reactions and digestive upset (bloating, flatulence, abdominal discomfort) have been reported with probiotics and enzymes, and occupational exposure to powdered proteolytic enzymes has caused allergic rhinitis and asthma in some workers.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lactase Bifidobacterium Breve Lactobacillus Acidophilus Bifidobacterium Bifidum Bifidobacterium Longum Streptococcus Thermophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 7 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Breve, Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antibiotic drugs, tell your pharmacist before starting this product — four of the probiotic strains may lose effectiveness if taken at the same time. You'll likely need to separate them by a few hours.

No other medication types show documented interactions with the ingredients we were able to check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TriActive Biotics Daily Care is designed for people wanting daily digestive and immune support through probiotics and enzymes. If you're taking antibiotics, space them several hours apart from this product to protect the live bacteria.

If you're immunocompromised, critically ill, or pregnant or breastfeeding, check with your doctor or pharmacist first — each ingredient has its own safety profile. Run your current medications through the checker below before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 21 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TriActive Biotics Daily Care, straight from the product label.

Brand Essential Source
Barcode (UPC) 019962875632
Net contents 34.5 Gram(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 176238
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TriActive Biotics Daily Care by Essential Source, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.15 Gram(s)
Maximum serving Sizes:
1.15 Gram(s)
Servings per container
30
UPC/BARCODE
019962875632
IngredientAmount% DV
Lactobacillus rhamnosus GG0 NP--
Protease, Fungal0 NP--
Amylase, Fungal0 NP--
Lactase, Fungal0 NP--
Bifidobacterium breve BR030 NP--
Lactobacillus plantarum LP010 NP--
Bifidobacterium lactis BS010 NP--
Lactobacillus acidophilus LA020 NP--
Lactobacillus plantarum LP090 NP--
Lactobacillus rhamnosus LR060 NP--
Lactobacillus casei LC030 NP--
Bifidobacterium bifidum BB010 NP--
Lactobacillus rhamnosus LR050 NP--
Bifidobacterium longum BL030 NP--
Lactobacillus reuteri LRE020 NP--
Bifidobacterium infantis BI020 NP--
Lactobacillus salivarius subsp. salivarius CRL13280 NP--
Bifidobacterium lactis BA050 NP--
FFe4 Fermented Fungal Enzyme Blend150 mg--
Prebiotic100 mg--
Cellulase, Fungal0 NP--
Streptococcus thermophilus YO80 NP--
Microencapsulated Probiotic Blend0 NP--

Other ingredients: Xanthan Gum, Xylitol, Inulin, Natural flavor(s), Medium Chain Triglycerides, Malic Acid, Rebaudioside A, Ester of Glycerol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

6 billion CFU before Bac5 activity

Take the TriActive Biotics challenge!

General Statements

For immune support and digestive health Microencapsulation ensures probiotic survival Prebiotic creates bacterial multiplication

We’re so sure TriActive Daily Care will bring you great results that we’ll reward you for taking it for three consecutive months! Just send us 3 proofs of purchase with $6.95 to cover shipping and handling, and we send you a 4th box for free! It’s that simple! ...Just send it to Essential Source 625 W. Deer Valley Rd. STE 103-152, Phoenix, AZ 85027

16 strains 5 times more effective with microencapsulation Maximum bacterial multiplication

Naturally sweetened Moisture defense bottle

This product was manufactured in a GMP approved facility.

The efficacy of this product has not been confirmed by clinical research, and traditional uses do not establish that this product will achieve any claimed result.

Microencapsulated probiotic Prebiotic blend Digestive enzyme 30 day supply Powder blend

TriActive Biotics Bac5 Activity is a process by which the prebiotic is delivered to the acidic environment of the stomach to balance the pH, and discourage the growth of unfriendly bacteria. It also causes bacterial multiplication for the protected probiotic blend, which is delivered safely to the intestine through microencapsulation. Microencapsulated probiotics have been shown in human clinical trials to colonize/adhere up to 5x better than typical or uncoated strains.

Simply put... 6 billion CFU of TriActive Biotics DC, is equal to or greater than 30 billion CFU of uncoated strains!

Seals/Symbols

100% non-GMO

GMP Good Manufacturing Practice Consistent quality

Made in USA

Storage

Storage: Store this product in a cool dry place below 23.5(0)C (75(0)F). Keep in a place with relative humidity below 30%RH. Keep product away from direct light.

Formulation

Allergens: None

No artificial colors or flavors Non GMO Allergen free Gluten free

Suggested/Recommended/Usage/Directions

Directions: One scoop daily. Best taken on empty stomach. Recommendation: Mix with 2-4 oz. of water or juice, yogurt or other favorite cold food, or sprinkled directly onto the tongue.

FDA Statement of Identity

Dietary Supplement

Formula

Includes FFe4 Fermented Fungal Enzyme Blend

TriActive Biotics Daily Care featuring Bac5

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to prevent, treat or cure any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TriActive Biotics Daily Care by Essential Source label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TriActive Biotics Daily Care label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TriActive Biotics Daily Care by Essential Source

These are the 21 active ingredients this product is made of. Select any to open its full monograph.

Serving size1.15 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

FFe4 Fermented Fungal Enzyme Blend

150 mg per serving

Prebiotic

100 mg per serving Form: organic VitaFiber-IMO

Microencapsulated Probiotic Blend

0 NP per serving

Other (inactive) ingredients: Xanthan Gum, Xylitol, Inulin, Natural flavor(s), Medium Chain Triglycerides, Malic Acid, Rebaudioside A, Ester of Glycerol. These complete the product’s ingredient list but are not active constituents.

Interaction report

TriActive Biotics Daily Care by Essential Source Drug Interactions

Want to check YOUR meds against TriActive Biotics Daily Care?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium breve BR03 182
Lactobacillus acidophilus LA02 182
Bifidobacterium bifidum BB01 182
Bifidobacterium longum BL03 182

Individual Drug Interactions

The ingredients in TriActive Biotics Daily Care interact with 182 drugs. Click any drug to see the details.

4 of the 21 ingredients in TriActive Biotics Daily Care interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium breve BR03 Lactobacillus acidophilus LA02 Bifidobacterium bifidum BB01 Bifidobacterium longum BL03

Each ingredient & the kinds of drugs it affects

For each ingredient in TriActive Biotics Daily Care with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium breve BR031 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve BR03 full monograph & interactions

Lactobacillus acidophilus LA021 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus LA02 full monograph & interactions

Bifidobacterium bifidum BB011 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum BB01 full monograph & interactions

Bifidobacterium longum BL031 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum BL03 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TriActive Biotics Daily Care, from the product label.

Essential Source

See all Essential Source products
Name
Essential Source, Inc.
Street Address
625 W. Deer Valley Road Suite 103-152
City
Phoenix
State
AZ
ZipCode
85027
Phone Number
(877) 879-9966
Web Address
www.EssentialSource.net
Pharmacist Counseling Corner

TriActive Biotics Daily Care by Essential Source: Common Questions

Does TriActive Biotics Daily Care by Essential Source interact with any medications?
Yes. Based on its ingredients, TriActive Biotics Daily Care has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TriActive Biotics Daily Care contains 21 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product help my lactose intolerance?
The Lactase enzyme in this product is effective for lactose intolerance. However, this is a multi-ingredient probiotic powder, so if you're looking for a pure lactase supplement, you might want to compare options with your pharmacist to make sure the dose and form are right for your needs.
Can I take this while I'm pregnant?
The safety data varies by ingredient. Bifidobacterium longum is rated possibly safe in pregnancy, but Protease should be avoided during pregnancy unless prescribed. For several other ingredients, there isn't enough data — you'd need to talk with your doctor or pharmacist to weigh the risks and benefits for your specific situation.
Can I take this while breastfeeding?
Safety data during breastfeeding is limited for most of these ingredients. Protease use is not recommended without medical advice, and Lactase requires checking with your doctor first. The other ingredients haven't been well studied in breastfeeding, so discuss this product with your healthcare provider before starting.
What if I'm taking antibiotics — can I take this at the same time?
No — several of the probiotic bacteria in this product (Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacterium longum) can be killed by antibiotics, which defeats the purpose of taking them. Ask your pharmacist how many hours to wait between your antibiotic and this product so both work as intended.
What are the side effects I should watch for?
Most people tolerate this product well, but bloating, flatulence, and abdominal discomfort can occur, especially when you first start. Rare allergic reactions to the enzymes have been reported. If you notice rash, itching, difficulty breathing, or any unusual symptoms, stop and contact your doctor right away.
Is this safe if I have a weakened immune system?
You should check with your doctor first. The probiotic strains in this product carry a caution for people who are very ill, immunocompromised, or critically ill — in rare cases, these bacteria have caused bloodstream infections in such patients. Your doctor can advise whether this product is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TriActive Biotics Daily Care is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TriActive Biotics Daily Care label
Go deeper

The Full Monographs Behind TriActive Biotics Daily Care’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph →
Sources

Sources & How We Checked

TriActive Biotics Daily Care's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 77 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
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See these in context on the Bifidobacterium Bifidum monograph →

Bifidobacterium Longum 21 references
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Streptococcus Thermophilus 21 references
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See these in context on the Streptococcus Thermophilus monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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