TruAge Extra Ingredients & Drug Interactions
by Morinda
What is this page for?
First and foremost: checking TruAge Extra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
TruAge Extra is a dietary supplement by Morinda with 5 active ingredients. Its ingredients are commonly taken for antioxidant support, heart health, brain and memory health.Based on those ingredients, 616 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Morinda citrifolia (Noni) nectar, Vaccinium corymbosum (Blueberry) juice conc.. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against TruAge Extra by Morinda
Ask about any prescription or over-the-counter medication and we check it for interactions with TruAge Extra by Morinda — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of TruAge Extra by Morinda
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
TruAge Extra contains four active ingredients. The heart of the formula is a proprietary blend of iridoids and phenolic compounds — plant chemicals thought to support aging and wellness, though we hold incomplete data on them.
You're also getting blueberry juice concentrate, noni nectar, and olive leaf extract. Each brings different compounds: blueberry brings anthocyanins and other antioxidants; noni offers traditional tropical fruit elements; olive leaf provides polyphenols.
The product also contains inactive ingredients — grape juice concentrate, natural flavors, and cranberry juice concentrate — which serve as flavoring and texture.
Does it work?
Couldn't assess
The evidence for what TruAge Extra actually does is sparse. For blueberry, we have only conflicting or insufficient data — hypertension is rated possibly ineffective, while age-related cognitive decline, anxiety, athletic performance, and cardiovascular health all lack reliable evidence to rate.
Noni and olive leaf are similar: the data we hold doesn't establish either one for asthma, atherosclerosis, athletic performance, burns, cancer, or cardiovascular disease. What the proprietary blend is supposed to do isn't spelled out in the facts we have.
If you're considering this for a specific reason — say, memory or heart health — talk with us about what the actual research shows.
How safe is it?
Well-documented data
Blueberry is generally well tolerated, though freeze-dried blueberries can cause constipation, diarrhea, nausea, or vomiting — in one trial, 26% of people taking 50 grams daily quit the first week due to gut symptoms. Noni also seems generally well tolerated in moderate amounts, but it carries a rare but serious risk: hepatotoxicity (liver damage) has been reported, and cases have appeared in people aged 14 to 62.
Symptoms show up between 2 weeks and longer; liver function tests become abnormal. Olive leaf extract is well tolerated and generally causes only mild side effects like headache or stomach discomfort, though one person reported acne.
Olive pollen can trigger seasonal allergies if you're sensitive. On pregnancy: noni is a concern — it was traditionally used to cause abortion and should not be used in pregnancy.
Blueberry concentrated supplements haven't been well studied in pregnancy, so safety isn't clear — the facts advise caution. For breastfeeding, the safety of high-dose blueberry extracts is unknown, and noni safety while breastfeeding is not documented.
Olive leaf concentrated supplements in pregnancy and lactation also lack safety data. If you're pregnant or nursing, talk with your doctor or pharmacist before starting.
Meds to double-check
Moderate interaction found
Before taking TruAge Extra, double-check if you're on antihypertensive drugs (blood pressure medications), potassium-sparing diuretics, ACE inhibitors, or ARBs — noni carries Moderate interaction risks with all of these. Also check warfarin (a blood thinner) and phenytoin (an anti-seizure drug), which noni may interfere with at Moderate severity.
If you take antidiabetes drugs, flurbiprofen, or buspirone, there's a Minor theoretical risk from the blueberry. Olive leaf extract shows no documented interactions for the ingredients we could check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
TruAge Extra is built on noni, which does interact with common blood pressure medications, blood thinners, anti-seizure drugs, and potassium-raising medications — so if you take any of those, check your exact prescriptions first. The blueberry and olive components add minor risks with certain medications.
If you're pregnant, breastfeeding, or have liver concerns, discuss this product with your pharmacist or doctor before you use it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about TruAge Extra, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for TruAge Extra by Morinda, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 30 {Calories}, 15 {Calories} | -- |
| Total Carbohydrates | 5 Gram(s), 3 Gram(s) | 2%, 1% |
| Sugar | 3 Gram(s), 2 Gram(s) | -- |
| Proprietary Blend | 54 Gram(s), 27 Gram(s) | -- |
| Iridoids/Phenolic Compounds | 60 mg, 30 mg | -- |
| Vaccinium corymbosum (Blueberry) juice conc. | 0 Not Present, 0 Not Present | -- |
| Morinda citrifolia (Noni) nectar | 0 Not Present, 0 Not Present | -- |
| Olea europaea (olive) leaf extract | 0 Not Present, 0 Not Present | -- |
Other ingredients: Vitis vinifera (Grape) Juice Concentrate, Natural Flavors, Vaccinium macrocarpum (Cranberry) juice concentrate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Start by drinking 1 fluid ounce (30 ml) twice daily. Over time, adjust serving size based on personal needs. Shake well before using.
Storage
Refrigerate after opening.
Precautions
Do not use if seal around cap is broken.
Seals/Symbols
MORINDA
General
202938 1301086-US
Brand IP Statement(s)
(C)2013 Morinda, Inc.
Formula
60MG IRIDOIDS & PHENOLIC COMPOUNDS PER 60 ML made from Morinda Citrifolia Vaccinium Corymbosum Olea Europea
FDA Statement of Identity
DIETARY SUPPLEMENT
General Statements
PUT BACK IN WHAT LIFE TAKES OUT Age, stress, and extreme physical activity take a toll on your body. Extra delivers a potent blend of noni, blueberry, and olive iridoids that boosts energy and endurance, improves joint health, promotes heart health, enhances the immune system, and more.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, of prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
TruAge Extra by Morinda label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in TruAge Extra by Morinda
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 fl. Oz. Dosage formLiquid Servings per container25 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Sugar
Proprietary Blend
Iridoids/Phenolic Compounds
Other (inactive) ingredients: Vitis vinifera (Grape) Juice Concentrate, Natural Flavors, Vaccinium macrocarpum (Cranberry) juice concentrate. These complete the product’s ingredient list but are not active constituents.
TruAge Extra by Morinda Drug Interactions
HelloPharmacist Interaction Report
TruAge Extra by Morinda contains noni nectar, which does interact with a number of medications.
The most serious concern is with antihypertensive drugs (blood pressure medications) — noni may lower blood pressure further, creating a risk of excessively low blood pressure (hypotension). This is a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Additionally, noni carries Moderate-severity risks with potassium-sparing diuretics, ACE inhibitors, and ARBs (all used for blood pressure or heart conditions) because noni juice is high in potassium and could raise your potassium levels too much (hyperkalemia). There's also a Moderate concern with warfarin (a blood thinner) — noni may reduce its effectiveness — and with phenytoin (an anti-seizure medication), which noni could lower to unsafe levels.
Hepatotoxic drugs (medications that stress the liver) carry a Moderate risk if combined with noni due to rare liver injury concerns.
Blueberry juice concentrate in this product has Minor interactions with antidiabetes drugs (a small theoretical risk of low blood sugar), flurbiprofen (an anti-inflammatory), and buspiron (an anti-anxiety medication). We could not check iridoids/phenolic compounds — our data on that ingredient is incomplete.
Olive leaf extract shows no interactions in our data. Altogether, these interactions span 599 individual medications.
Run your exact prescriptions through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against TruAge Extra?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in TruAge Extra interact with 616 drugs. Click any drug to see the details.
2 of the 5 ingredients in TruAge Extra interact with drugs. Each result below shows which ingredient is responsible. Morinda citrifolia (Noni) nectar Vaccinium corymbosum (Blueberry) juice conc.
Acetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Pamabrom, Pyrilamine interactionAcetaminophen, PentazocineTalacen
How Acetaminophen, Pentazocine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Pentazocine interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetaminophen, PhenylpropanolamineTetra Caps
How Acetaminophen, Phenylpropanolamine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Phenylpropanolamine interactionAcetaminophen, Phenylpropanolamine, PhenyltoloxamineSinubid
How Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, PhenyltoloxaminePercogesic, Relagesic
How Acetaminophen, Phenyltoloxamine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Phenyltoloxamine interactionAcetaminophen, Phenyltoloxamine, SalicylamideLobac
How Acetaminophen, Phenyltoloxamine, Salicylamide interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Phenyltoloxamine, Salicylamide interactionAcetaminophen, PropoxypheneDarvocet-N 100, Darvocet-N 50, E-Lor, Wygesic
How Acetaminophen, Propoxyphene interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Propoxyphene interactionAcetaminophen, PseudoephedrineChildren's Tylenol Sinus, Dristan N.D., Non-Aspirin Sinus, Ornex, Ornex-Max, Sinutab +5 more
How Acetaminophen, Pseudoephedrine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Pseudoephedrine interactionAcetaminophen, Pseudoephedrine, TriprolidineActifed Plus ES
How Acetaminophen, Pseudoephedrine, Triprolidine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetaminophen, Pseudoephedrine, Triprolidine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with TruAge Extra — through 2 ingredients. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Acetohexamide interactionVaccinium Corymbosum (blueberry) Juice Conc.Antidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vaccinium Corymbosum (blueberry) Juice Conc. + Acetohexamide interactionAdagrasibKrazati
How Adagrasib interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Adagrasib interactionAldesleukinProleukin
How Aldesleukin interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Aldesleukin interactionAlectinib HydrochlorideAlecensa
How Alectinib Hydrochloride interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Alectinib Hydrochloride interactionAliskirenTekturna
How Aliskiren interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Aliskiren interactionAllopurinolCaplenal, Cosuric, Rimapurinol, Zyloprim, Zyloric
How Allopurinol interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Allopurinol interactionAlogliptinNesina
How Alogliptin interacts with TruAge Extra — through 2 ingredients. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Alogliptin interactionVaccinium Corymbosum (blueberry) Juice Conc.Antidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vaccinium Corymbosum (blueberry) Juice Conc. + Alogliptin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with TruAge Extra — through 2 ingredients. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Alogliptin, Pioglitazone interactionVaccinium Corymbosum (blueberry) Juice Conc.Antidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Vaccinium Corymbosum (blueberry) Juice Conc. + Alogliptin, Pioglitazone interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs, Potassium-sparing Diuretics Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarPotassium-sparing Diuretics, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Read the full Morinda Citrifolia (noni) Nectar + Amiloride, Hydrochlorothiazide interactionAminosalicylic AcidPaser
How Aminosalicylic Acid interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Aminosalicylic Acid interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
Read the full Morinda Citrifolia (noni) Nectar + Amiodarone interactionAmlodipineNorliqva
How Amlodipine interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs, Ace Inhibitors (aceis) Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with TruAge Extra — through 1 ingredient. Tap an ingredient for the detail:
Morinda Citrifolia (noni) NectarAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Read the full Morinda Citrifolia (noni) Nectar + Amlodipine, Celecoxib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in TruAge Extra with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Morinda citrifolia (Noni) nectar
Ace Inhibitors (Aceis)
Theoretically, combining noni and ACE inhibitors might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ACE inhibitors, which can also increase potassium levels.
Angiotensin Receptor Blockers (Arbs)
Theoretically, combining noni and ARBs might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with ARBs, which can also increase potassium levels.
Antihypertensive Drugs
Theoretically, noni may increase the risk of hypotension when used in combination with antihypertensive drugs.
Preliminary clinical research suggests that drinking noni juice can reduce blood pressure in individuals with hypertension.
Hepatotoxic Drugs
Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.
There is concern that noni might cause hepatotoxicity in some patients. Advise patients against combining noni with potentially hepatotoxic drugs.
Phenytoin (Dilantin)
Theoretically, taking noni fruit juice concomitantly with phenytoin may lower phenytoin levels and increase the risk of seizures.
In one case report, an adult taking phenytoin for partial seizures experienced low serum phenytoin levels while taking noni juice 90-200 mL daily. Serum phenytoin levels increased after decreasing noni juice consumption; similarly, serum phenytoin levels decreased after increasing noni juice consumption. Some researchers believe noni juice may induce cytochrome P450 2C9 enzymes, which would decrease phenytoin levels, but this has not been well studied. Patients may need additional monitoring when starting or stopping noni juice supplementation.
Potassium-Sparing Diuretics
Theoretically, combing noni and a potassium-sparing diuretic might increase the risk of hyperkalemia.
Noni juice contains significant amounts of potassium, about 6 mEq/100 mL juice. This may increase the risk for hyperkalemia when used in conjunction with potassium-sparing diuretics, which can also increase potassium levels.
Warfarin (Coumadin)
Theoretically, taking noni juice concomitantly with warfarin might decrease the effectiveness of warfarin.
In one case, a 41-year-old patient stabilized on warfarin had a decreased international normalized ratio (INR) following consumption of a specific commercial noni juice product (Noni juice 4 Everything). While the patient was still taking noni juice, an increase in warfarin dose did not produce an increase in INR. However, it should be noted that this particular product contained extracts and derivatives from more than 115 components, many of which contained vitamin K. Furthermore, vitamin K was listed as a separate ingredient of the product, suggesting that the product was possibly fortified with vitamin K. It has not been verified that noni fruit alone contains a significant amount of vitamin K or interacts with warfarin.
Ranitidine (Zantac)
Taking noni fruit with ranitidine might increase the levels and clinical effects of ranitidine.
Clinical evidence shows that taking an aqueous extract of noni fruit 30 minutes prior to taking a single oral dose of ranitidine can increase the rate of absorption and plasma concentration of ranitidine.
Vaccinium corymbosum (Blueberry) juice conc.
Antidiabetes Drugs
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.
Buspirone (Buspar)
Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.
Flurbiprofen (Ansaid, Others)
Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.
Brand information
Manufacturer and brand details for TruAge Extra, from the product label.
Morinda
See all Morinda products- Name
- Morinda, Inc.
- Street Address
- 333 West River Park Drive
- City
- Provo
- State
- Utah
- ZipCode
- 84604
TruAge Extra by Morinda: Common Questions
Does TruAge Extra by Morinda interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take TruAge Extra if I'm on blood pressure medication?
Is TruAge Extra safe during pregnancy?
What's the proprietary blend in here, and why isn't it listed by ingredient?
Can TruAge Extra help with memory or brain health?
What are the most common side effects?
Does TruAge Extra interact with warfarin or other blood thinners?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if TruAge Extra is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind TruAge Extra’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Blueberry
Interacts with 88 drugsBlueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...
Read the full Blueberry monograph → Herb & supplement monographNoni
Interacts with 542 drugsNoni is a tropical fruit used widely in folk medicine and sold mostly as a juice or supplement, but solid human evidence for its many claimed benefits is limited. While moderate juice intake...
Read the full Noni monograph → Herb & supplement monographOlive
Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...
Read the full Olive monograph →Sources & How We Checked
TruAge Extra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 25 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Blueberry 7 references
- Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
- Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
- Martineau, L. C., Couture, A., Spoor, D., Benhaddou-Andaloussi, A., Harris, C., Meddah, B., Leduc, C., Burt, A., Vuong, T., Mai, Le P., Prentki, M., Bennett, S. A., Arnason, J. T., and Haddad, P. S. Anti-diabetic properties of the Canadian lowbush bluebe
- Vuong, T., Martineau, L. C., Ramassamy, C., Matar, C., and Haddad, P. S. Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes. Can J Physiol Pharma
- Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolnikowski GG, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013 Apr;75(4):1041-52. PubMed
- Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010;140(9):1582-7. PubMed
- Basu A, Feng D, Planinic P, Ebersole JL, Lyons TJ, Alexander JM. Dietary blueberry and soluble fiber supplementation reduces risk of gestational diabetes in women with obesity in a randomized controlled trial. J Nutr 2021;151(5):1128-38. PubMed
Noni 16 references
- Mueller BA, Scott MK, Sowinski KM, Prag KA. Noni juice (Morinda citrifolia): hidden potential for hyperkalemia? Am J Kidney Dis 2000;35:310-2. PubMed
- Millonig G, Stadlmann S, Vogel W. Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-7. PubMed
- Stadlbauer V, Fickert P, Lackner C, et al. Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-60. PubMed
- Carr ME, Klotz J, Bergeron M. Coumadin resistance and the vitamin supplement "Noni". Am J Hematol 2004;77:103. PubMed
- Jensen CJ, Westendorf J, Wang MY, Wadsworth DP. Noni juice protects the liver. Eur J Gastroenterol Hepatol 2006;18:575-7. PubMed
- Yuce B, Gulberg V, Diebold J, Gerbes AL. Hepatitis induced by noni juice from morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-70.
- Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine 2007;14 Suppl 6:40-5. PubMed
- Yu EL, Sivagnanam M, Ellis L, Huang JS. Acute hepatotoxicity after ingestion of Morinda citrifolia (noni berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-4.
- Stadlbauer V, Weiss S, Payer F, Stauber RE. Herbal does not at all mean innocuous: the sixth case of hepatotoxicity associated with morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-7. PubMed
- López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A. [Hepatotoxicity caused by a noni (Morinda citrifolia) preparation]. [Article in Spanish] Rev Esp Enferm Dig 2007;99:179-81.
- Nima S, Kasiwong S, Ridtitid W, et al. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142(2):354-61. PubMed
- Issell, B. F., Gotay, C. C., Pagano, I., and Franke, A. A. Using quality of life measures in a Phase I clinical trial of noni in patients with advanced cancer to select a Phase II dose. J.Diet.Suppl 2009;6(4):347-359. PubMed
- Palu AK, Santiago RA West B Kaluhiokalani N Jensen J. The Effects of Morillda citrifolia L. Noni on High Blood Pressure: A Mechanistic Investigation and Case Study. ACS SYMPOSIUM SERIES 993 2008;
- Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
- Bussmann RW, Hennig L, Giannis A, Ortwein J, Kutchan TM, Feng X. Anthraquinone Content in Noni (Morinda citrifolia L.). Evid Based Complement Alternat Med. 2013;2013:208378.
- Yu-Chan Kang, Ming-Hong Chen, Shung-Lon Lai. Potentially Unsafe Herb-drug Interactions Between a Commercial Product of Noni Juice and Phenytoin- A Case Report. Acta Neurol Taiwan. 2015 Jun;24(2):43-6.
Olive 2 references
- Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
- Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC