Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

TruBiotics Ingredients & Drug Interactions

by TruBiotics

TruBiotics label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TruBiotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TruBiotics is a dietary supplement by TruBiotics with 3 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus LA-5. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TruBiotics by TruBiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with TruBiotics by TruBiotics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TruBiotics by TruBiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 8, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 3 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (26 mg) without saying how much of each component you get.

TruBiotics contains three active ingredients: fructooligosaccharides (FOS), Lactobacillus acidophilus LA-5, and Bifidobacterium animalis lactis BB-12. The product also includes a proprietary probiotic blend, which is a container whose component ingredients are listed individually.

The inactive ingredients are hypromellose, titanium dioxide, purified water, carrageenan, potassium chloride, maltodextrin, and magnesium stearate. These are fillers and other non-active components, not medicines.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive and immune health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Lactobacillus acidophilus is rated possibly effective for Helicobacter pylori, bacterial vaginosis, antibiotic-associated diarrhea, and irritable bowel syndrome (IBS). It is rated possibly ineffective for atopic disease, and there is insufficient reliable evidence to rate it for allergic rhinitis (hay fever).

FOS is rated as having insufficient reliable evidence for every condition we hold, including constipation, osteoporosis, and atopic dermatitis (eczema). We hold no effectiveness ratings for BB-12.

The evidence, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

FOS is generally well tolerated in food amounts, but it can cause gas and bloating, especially at higher doses. Supplement-level doses are not well studied.

A meta-analysis of 8 small clinical studies found that doses of 2.5 to 15 grams daily for up to 8 weeks did not increase abdominal pain, bloating, flatulence, or intestinal sounds compared with control groups. Lactobacillus acidophilus is generally well tolerated in healthy adults and children.

Its side effects can include gas, bloating, and diarrhea, but these are uncommon. Pregnancy is rated possibly safe for it, while lactation has no rating on file.

Our data on file for FOS has no pregnancy or breastfeeding rating, and we hold no pregnancy or breastfeeding data for BB-12.

Side effects, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The medication type to double-check is antibiotic drugs, with a Moderate severity interaction tied to Lactobacillus acidophilus. No other interactions are documented for the ingredients we could check, but we hold no interaction data for BB-12, so please confirm your full list with your own doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TruBiotics may be worth considering if you are looking at a probiotic and fiber combination and want to know what the ingredients have been studied for. If you take antibiotics, or are pregnant, breastfeeding, or have a medical condition, be more careful and talk it over with your own doctor or pharmacist before you start.

They can look at your full medication list and your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TruBiotics, straight from the product label.

Brand TruBiotics
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 316470
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TruBiotics by TruBiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Fructooligosaccharides150 mg--
Proprietary Probiotic Blend26 mg--
Lactobacillus acidophilus LA-50 NP--
Bifidobacterium animalis lactis BB-120 NP--

Other ingredients: Hypromellose, Titanium Dioxide, Water, Purified, Carrageenan, Potassium Chloride, Maltodextrin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Why should I take TruBiotics? Taking probiotics every day helps maintain the natural balance of good bacteria in your digestive tract that is impacted by lifestyle factors including diet, stress and travel. Works 2 ways Digestive health Immune health Helps both your digestive and immune systems work their best Supports the 70% of your immune system found in the digestive tract The TruBiotics Promise: Made with the highest product and quality standards Guaranteed potency through the expiration date when stored as directed

Naturally helps to Keep your digestive system running smoothly Maintain peak immunity Support a healthy metabolism Easy-to-swallow capsule

Dairy free, gluten free, soy free Meets FDAs guidelines for gluten-free Vegetarian capsules do not contain animal-based gelatin

Do more for your microbiome and overall health TruBiotics supports your digestive and immune health

Vegetarian capsules do not contain animal-based gelatin

Formula

Contains a proprietary blend of the 2 most clinically studied types of good bacteria Unique formula with the 2 most clinically studied types of bacteria Daily probiotic supplement with prebiotics

Guaranteed 2 billion Colony Forming Units (CFUs) per serving at time of expiration

General Statements

Actual size

Questions? Comments? 1-800-353-3343 (Mon-Fri 9AM-6PM ET)

Suggested/Recommended/Usage/Directions

Directions: Adults - Take one capsule daily.

Precautions

If you are pregnant or breastfeeding, ask a health professional before use.

Do not exceed recommended intake. Tamper evident: Do not use if any part of cap printed liner seal is torn or missing.

Keep out of reach of children.

Product is produced in a facility that also handles dairy ingredients

Storage

Store at room temperature. Avoid excessive heat. Replace cap after use.

Brand IP Statement(s)

TruBiotics, TruBiotics design are registered trademarks of PanTheryx, Inc.

BB-12 is a registered trademark of Chr. Hansen A/S.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TruBiotics by TruBiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TruBiotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TruBiotics by TruBiotics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fructooligosaccharides

No known
interactions
150 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Proprietary Probiotic Blend

26 mg per serving

Other (inactive) ingredients: Hypromellose, Titanium Dioxide, Water, Purified, Carrageenan, Potassium Chloride, Maltodextrin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

TruBiotics by TruBiotics Drug Interactions

Want to check YOUR meds against TruBiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus LA-5 182

Individual Drug Interactions

The ingredients in TruBiotics interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in TruBiotics interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus LA-5

Each ingredient & the kinds of drugs it affects

For each ingredient in TruBiotics with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus LA-51 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus LA-5 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TruBiotics, from the product label.

TruBiotics

See all TruBiotics products
Name
TruBiotics
Pharmacist Counseling Corner

TruBiotics by TruBiotics: Common Questions

Does TruBiotics by TruBiotics interact with any medications?
Yes. Based on its ingredients, TruBiotics has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TruBiotics contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is TruBiotics safe to take during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy in our data. We do not have a pregnancy rating on file for FOS or BB-12, so there is not enough data to know how they would affect you. Please talk with your doctor or pharmacist for advice about your situation.
Does FOS help with constipation?
The evidence is rated as insufficient reliable evidence to rate for constipation in our data. That means the research we hold does not establish whether it helps.
What side effects can FOS cause?
FOS is generally well tolerated in food amounts, but it can cause gas, bloating, and abdominal pain, especially at higher doses. Supplement-level doses are not well studied.
Does Lactobacillus acidophilus help with irritable bowel syndrome?
It is rated possibly effective for irritable bowel syndrome (IBS) in our data. That is a rating of possible benefit, not proof, so discuss it with your own healthcare provider.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TruBiotics is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TruBiotics label
Go deeper

The Full Monographs Behind TruBiotics’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

TruBiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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