Ultra Beets Delicious Natural Cherry Apple Flavor Ingredients & Drug Interactions
by KaraMD
What is this page for?
First and foremost: checking Ultra Beets Delicious Natural Cherry Apple Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ultra Beets Delicious Natural Cherry Apple Flavor is a dietary supplement by KaraMD with 3 active ingredients. Its ingredients are commonly taken for general nutrition and fiber intake, heart and cholesterol health, blood sugar and weight management.Based on those ingredients, 966 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Beetroot powder, Apple juice powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD
Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Ultra Beets Delicious contains 3 active ingredients: apple juice powder, hibiscus flower powder, and beetroot powder. Apple juice powder provides polyphenols and natural sugars from apples.
Hibiscus flower powder is a traditional botanical extract. Beetroot powder delivers concentrated betalains (plant pigments) and nitrates — compounds that research suggests may support athletic performance and muscle recovery after exercise.
The powder also contains stevia leaf extract and maltodextrin as inactive ingredients.
Does it work?
Moderate evidence
The evidence on beetroot powder shows it's possibly effective for athletic performance and exercise-induced muscle soreness — meaning there's some clinical support but the studies are typically small or mixed. For other uses tracked in our data — cognitive function, cholesterol levels, and COPD — either the evidence is insufficient or it appears ineffective.
For apple juice powder, we have insufficient evidence to rate effectiveness for Alzheimer disease, cancer, dental plaque, diabetes, and diarrhea. There is no effectiveness data on file for hibiscus flower powder.
How safe is it?
Well-documented data
Apple juice powder as a food ingredient is generally well tolerated in normal amounts. The most common side effects are bloating and flatulence.
Rare but serious concerns include allergic reactions (and very rarely anaphylaxis) in people sensitive to apple or related fruits like apricot, peach, pear, or strawberry. Apple seeds contain cyanide and can cause serious poisoning in large amounts, though the amount of apple seed in a supplement is typically minimal.
For beetroot powder, common effects include red or black discoloration of stool, which is harmless. In large quantities it may theoretically cause low blood calcium or kidney issues, and there's one case report of black stools in someone taking beet pills alongside blood thinners.
Beetroot as a food is fine, but concentrated supplements lack full safety data, so use caution. We have no pregnancy or breastfeeding safety data on file for beetroot powder.
Apple as a food is considered safe in pregnancy and while breastfeeding, but concentrated apple extracts are not well studied.
Meds to double-check
Major interaction found
Check before starting if you take OATP substrates (Major severity) — a group of medications whose blood levels can drop sharply with apple juice. You should also verify any antihypertensive (blood pressure) drugs, atenolol, fexofenadine, aliskiren, lithium, diabetes medications, or drugs processed through the liver enzyme CYP3A4, as apple juice or beetroot powder may interfere with their effectiveness or levels.
If you're on a blood thinner like apixaban or clopidogrel, mention this product to your pharmacist because of one reported case linking beet supplements to gastrointestinal effects.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Ultra Beets Delicious is primarily useful if you're looking to support athletic performance or recover from exercise — that's where the beetroot evidence is strongest. If you take any medications, especially for blood pressure, allergies, diabetes, or heart rhythm, check your specific drugs with the tool on this page before starting.
Talk to your pharmacist if you have a known allergy to apples or related fruits, or if you're pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ultra Beets Delicious Natural Cherry Apple Flavor, straight from the product label.
| Brand | KaraMD |
|---|---|
| Barcode (UPC) | X0023AXF03 |
| Net contents | 4.23 Ounce(s); 120 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2021 |
| DSLD ID | 243839 |
| Product type | Botanical With Nutrients |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Total Sugars | 1 Gram(s) | -- |
| Apple juice powder | 0 NP | -- |
| Hibiscus flower powder | 0 NP | -- |
| Beetroot powder | 0 NP | -- |
| Heart Health Blend | 3833 mg | -- |
Other ingredients: Stevia leaf extract, Maltodextrin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Copyright 2019
Seals/Symbols
Made in the USA
Formulation
Non GMO
Vegan
General Statements
90 Day Money Back Guarantee
Suggested/Recommended/Usage/Directions
Suggested Use: Add 1 scoop of UltraBeets with 8 fl oz of water or your favorite beverage and mix well.
Precautions
Consult your physician if you have any medical condition, you're pregnant/lactating or under 18, or if you're taking any medications.
Consult your physician if you have any medical condition, you're pregnant/lactating or under 18, or if you're taking any medications.
Do not use if safety seal is damaged or missing.
Keep out of reach of children.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Heart Health and Circulation Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Gram(s) Dosage formPowder Servings per container40 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Heart Health Blend
- › Apple juice powder
- › Hibiscus flower powder
- › Beetroot powder
Other (inactive) ingredients: Stevia leaf extract, Maltodextrin. These complete the product’s ingredient list but are not active constituents.
Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD Drug Interactions
HelloPharmacist Interaction Report
Ultra Beets Delicious by KaraMD contains apple juice powder and beetroot powder, both of which have documented interactions with medications.
The most serious concern is apple juice powder's Major-severity interaction with OATP substrates (organic anion-transporting polypeptide substrates) — a group of drugs whose absorption can drop significantly when taken with apple juice. This means blood levels of certain medications may fall well below therapeutic range, making them less effective.
Read the full breakdown — every affected drug type, severity by severity
Apple juice powder also interacts with several drug types at Moderate severity. It can substantially lower blood levels of specific heartburn and blood pressure medications like fexofenadine (Allegra) and atenolol (Tenormin), and it may interfere with diabetes drugs and blood pressure control more broadly.
There's also concern about its effect on lithium levels. Beetroot powder carries Moderate-severity interactions with drugs processed by a liver enzyme called CYP3A4 (cytochrome P450 3A4 substrates) — potentially raising their levels — and Minor-severity interactions with blood pressure medications and another set of enzyme-processed drugs (CYP1A2 substrates).
We could not check hibiscus flower powder for interactions. Altogether, these interactions span 954 individual medications.
Please run your exact medications through the interaction checker on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ultra Beets Delicious Natural Cherry Apple Flavor?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ultra Beets Delicious Natural Cherry Apple Flavor interact with 966 drugs. Click any drug to see the details.
2 of the 3 ingredients in Ultra Beets Delicious Natural Cherry Apple Flavor interact with drugs. Each result below shows which ingredient is responsible. Beetroot powder Apple juice powder
AtorvastatinAtorvaliq
How Atorvastatin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Atorvastatin interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Atorvastatin Calcium interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Atorvastatin Calcium interactionBosentanTracleer
How Bosentan interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp), Antihypertensive Drugs Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Bosentan interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Bosentan interactionBrincidofovirTembexa
How Brincidofovir interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Brincidofovir interactionCeliprololCelicard
How Celiprolol interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderAntihypertensive Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Read the full Apple Juice Powder + Celiprolol interactionBeetroot PowderAntihypertensive Drugs Minor
Interaction Summary
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.
Read the full Beetroot Powder + Celiprolol interactionCerivastatin SodiumBaycol
How Cerivastatin Sodium interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Cerivastatin Sodium interactionCinoxacinCinobac
How Cinoxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Cinoxacin interactionCiprofloxacinCiloxan, Cipro, Cipro IV, Cipro XR, Ciprobay, Otiprio
How Ciprofloxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Ciprofloxacin interactionCiprofloxacin, HydrocortisoneCipro HC Otic
How Ciprofloxacin, Hydrocortisone interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Ciprofloxacin, Hydrocortisone interactionClinafloxacinClinafloxacin
How Clinafloxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Clinafloxacin interactionEnoxacinPenetrex
How Enoxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Enoxacin interactionEtoposideEtopophos, VePesid, VP16
How Etoposide interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Etoposide interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Etoposide interactionEzetimibe, AtorvastatinLiptruzet
How Ezetimibe, Atorvastatin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Ezetimibe, Atorvastatin interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Ezetimibe, Atorvastatin interactionFexofenadineAllegra
How Fexofenadine interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp), Fexofenadine (allegra) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Fexofenadine interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Fexofenadine interactionFexofenadine, PseudoephedrineAllegra D
How Fexofenadine, Pseudoephedrine interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp), Fexofenadine (allegra) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Fexofenadine, Pseudoephedrine interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Fexofenadine, Pseudoephedrine interactionFluvastatinLescol, Lescol XL
How Fluvastatin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Fluvastatin interactionGatifloxacinTequin, Tequin Injection
How Gatifloxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Gatifloxacin interactionGemifloxacinFactive
How Gemifloxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Gemifloxacin interactionGlyburideAlbert Glyburide, Diabeta, Glycron, Glynase, Glynase PresTab, Micronase +1 more
How Glyburide interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderAntidiabetes Drugs, Organic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Read the full Apple Juice Powder + Glyburide interactionGlyburide, MetforminGlucovance
How Glyburide, Metformin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp), Antidiabetes Drugs Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Glyburide, Metformin interactionGrepafloxacinRaxar
How Grepafloxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Grepafloxacin interactionBeetroot PowderCytochrome P450 1a2 (cyp1a2) Substrates Minor
Interaction Summary
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Beetroot Powder + Grepafloxacin interactionIrinotecanCamptosar, Onivyde
How Irinotecan interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Irinotecan interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Irinotecan interactionIrinotecan Hydrochloride
How Irinotecan Hydrochloride interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Irinotecan Hydrochloride interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Irinotecan Hydrochloride interactionIsoniazid, Pyrazinamide, RifampinRifater
How Isoniazid, Pyrazinamide, Rifampin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Isoniazid, Pyrazinamide, Rifampin interactionIsoniazid, RifampinRifamate
How Isoniazid, Rifampin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Isoniazid, Rifampin interactionLevofloxacinLeva-pak, Levaquin, Levaquin Injection
How Levofloxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Levofloxacin interactionLevofloxacin (ophthalmic)Levofloxacin
How Levofloxacin (ophthalmic) interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Levofloxacin (ophthalmic) interactionLomefloxacinMaxaquin
How Lomefloxacin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Lomefloxacin interactionLovastatinAltocor, Mevacor
How Lovastatin interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 2 ingredients. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Lovastatin interactionBeetroot PowderCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, beet might increase the levels of CYP3A4 substrates.
Read the full Beetroot Powder + Lovastatin interactionMethotrexateOtrexup, Rasuvo, Reditrex, Rheumatrex
How Methotrexate interacts with Ultra Beets Delicious Natural Cherry Apple Flavor — through 1 ingredient. Tap an ingredient for the detail:
Apple Juice PowderOrganic Anion-transporting Polypeptide Substrates (oatp) Major
Interaction Summary
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Read the full Apple Juice Powder + Methotrexate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ultra Beets Delicious Natural Cherry Apple Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Beetroot powder
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.
Antihypertensive Drugs
Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.
Apple juice powder
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Research shows that consuming apple juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. Fexofenadine, atenolol, and aliskiren are substrates of OATP. Clinical research shows that coadministration of apple juice decreases bioavailability of fexofenadine by up to 78%, aliskiren by 63%, and atenolol by up to 82%. These effects appear to increase with larger quantities of apple juice. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Aliskiren (Tekturna, Rasilez)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of aliskiren.
Pharmacokinetic research shows that coadministration of apple juice 200 mL along with aliskiren 150 mg decreases the bioavailability of aliskiren by 63%. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Antidiabetes Drugs
Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Clinical research suggests that consuming apples or drinking apple juice can raise blood glucose levels, with the effects of drinking apple juice being more significant than consuming apples.
Antihypertensive Drugs
Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Some clinical evidence suggests that consuming apple and cherry juice can increase blood pressure in elderly patients.
Atenolol (Tenormin)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of atenolol.
Pharmacokinetic research shows that coadministration of apple juice 600-1200 mL decreases levels of atenolol by 58% to 82% in a dose-dependent manner. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Fexofenadine (Allegra)
Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of fexofenadine.
Pharmacokinetic research shows that coadministration of apple juice 400-1200 mL along with fexofenadine 60-120 mg decreases bioavailability of fexofenadine by up to 78%. Coadministration with smaller quantities of apple juice (150 mL or less) does not appear to affect the bioavailability of fexofenadine. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.
Lithium
There is some concern that concomitant consumption of apple juice might decrease oral absorption and blood levels of lithium.
In one case report, a patient had an undetectable serum lithium level when lithium citrate was administered with apple juice. When lithium was administered with an alternative beverage, the lithium level became detectable and the patient demonstrated clinical improvement.
Brand information
Manufacturer and brand details for Ultra Beets Delicious Natural Cherry Apple Flavor, from the product label.
KaraMD
See all KaraMD products- Name
- KaraMD, Inc
- Street Address
- 3100 East 45th Street Suite 234 #109
- City
- Cleveland
- State
- OH
- ZipCode
- 44127
- Phone Number
- (800) 991-4518
- Web Address
- KaraMD.com
Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD: Common Questions
Does Ultra Beets Delicious Natural Cherry Apple Flavor by KaraMD interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What's actually in this — is it just beet juice?
Will it actually help my workout recovery?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I notice?
Is it safe if I'm allergic to apples?
My stool turned black after I started taking this. Should I be worried?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ultra Beets Delicious Natural Cherry Apple Flavor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Apple
Interacts with 300 drugsApples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into a healthy diet. While research suggests apples may...
Read the full Apple monograph → Herb & supplement monographBeet
Interacts with 861 drugsBeet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but s...
Read the full Beet monograph →Sources & How We Checked
Ultra Beets Delicious Natural Cherry Apple Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Apple 16 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
- Rodriguez J, Crespo JF, Lopez-Rubio A, et al. Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol 2000;106:183-189. PubMed
- Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
- Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
- Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed
- Tapaninen T, Neuvonen PJ, Niemi M. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol 2011;71:718-26. PubMed
- Jeon H, Jang IJ, Lee S, et al. Apple juice greatly reduces systemic exposure to atenolol. Br J Clin Pharmacol 2012 May 11. doi: 10.1111/j.1365-2125.2012.04324.x. [Epub ahead of print]. PubMed
- Visvanathan, R., Chen, R., Horowitz, M., and Chapman, I. Blood pressure responses in healthy older people to 50 g carbohydrate drinks with differing glycaemic effects. Br J Nutr 2004;92(2):335-340. PubMed
- Asp, N. G., Agardh, C. D., Ahren, B., Dencker, I., Johansson, C. G., Lundquist, I., Nyman, M., Sartor, G., and Schersten, B. Dietary fibre in type II diabetes. Acta Med Scand Suppl 1981;656:47-50. PubMed
- Akamine Y, Miura M, Komori H, et al. Effects of one-time apple juice ingestion on the pharmacokinetics of fexofenadine enantiomers. Eur J Clin Pharmacol. 2014 Sep;70(9):1087-95. PubMed
- Luo J, Imai H, Ohyama T, et al. The Pharmacokinetic Exposure to Fexofenadine is Volume-Dependently Reduced in Healthy Subjects Following Oral Administration With Apple Juice. Clin Transl Sci. 2016 Aug;9(4):201-6. PubMed
- Tsiougkos N, Vovolis V. Repeated anaphylactic episodes to orange and apple. Eur Ann Allergy Clin Immunol. 2013 May;45(3):113-5.
- Rubido S, García-Caballero L, Abeleira MT, Limeres J, García M, Diz P. Effect of chewing an apple on dental plaque removal and on salivary bacterial viability. PLoS One. 2018;13(7):e0199812. PubMed
- Krishnasamy S, Lomer MCE, Marciani L, et al. Processing apples to puree or juice speeds gastric emptying and reduces postprandial intestinal volumes and satiety in healthy adults. J Nutr 2020;150(11):2890-9. PubMed
- Awan S, Abelleira A, Khehra L, Hieber R. Undetectable serum lithium concentrations after coadministration of liquid lithium citrate and apple juice: A case report. Ment Health Clin. 2021;11(1):27-30. PubMed
Beet 14 references
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
- Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
- Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
- Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
- Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
- Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
- Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
- Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
- Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
- Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
- Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC