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Dietary supplement

VenoFlow Ingredients & Drug Interactions

by Life Extension

VenoFlow label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking VenoFlow against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

VenoFlow is a dietary supplement by Life Extension with 2 active ingredients. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 494 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pycnogenol French Maritime Pine extract, Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against VenoFlow by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with VenoFlow by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of VenoFlow by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “VenoFlow Proprietary Blend” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.

VenoFlow contains two active ingredients: nattokinase, a fibrin-breaking enzyme derived from fermented soybeans, and Pycnogenol French Maritime Pine extract, a standardized plant compound. The product also includes several inactive ingredients—microcrystalline cellulose, vegetable cellulose, dextrin, stearic acid, and silica—which serve as fillers and binders to hold the capsule together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: circulation and vein health support.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Varicose veins, Venous insufficiency, Peripheral arterial disease (PAD), Raynaud syndrome, Hypertension — and 4 related terms.
  • The strongest evidence on file: Maritime Pine is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Maritime Pine is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Hypertension, Varicose veins, Raynaud syndrome.
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD).

The evidence for nattokinase in this product is not yet well established. Our data shows insufficient reliable evidence to rate its use for angina, atherosclerosis, cancer, cardiovascular disease, or chronic fatigue syndrome.

Pycnogenol French Maritime Pine extract has stronger evidence: it's rated possibly effective for osteoarthritis and chronic venous insufficiency (a condition affecting blood flow in the veins), and possibly effective for asthma. For high cholesterol (hyperlipidemia), it's rated possibly ineffective.

The evidence, ingredient by ingredient Nattokinase Maritime Pine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally tolerated short-term, but because of its blood-thinning effects, it warrants caution in anyone at risk of bleeding. It's not recommended during pregnancy or breastfeeding due to insufficient safety data.

Rare reports of bleeding, including a case of brain hemorrhage, have been documented. People sensitive to natto (fermented soybeans) may experience hypersensitivity reactions, including anaphylaxis, with symptoms in the throat and mouth within 2 hours of taking it.

Pycnogenol is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are gastrointestinal upset, dizziness, and vertigo; headache and a single report of chest pain have also been noted.

Pycnogenol is rated possibly safe in pregnancy, but safety during breastfeeding isn't known, so it's best avoided.

Side effects, ingredient by ingredient Nattokinase Maritime Pine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Maritime Pine, Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 494 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking VenoFlow, double-check with your doctor or pharmacist if you're on blood thinners (anticoagulants) or blood thinner-like medications (antiplatelet drugs), as both ingredients carry Moderate-severity bleeding risk. Also confirm your use if you take blood pressure medications, diabetes drugs, or any immunosuppressants—all carry Moderate-severity interactions that may require dose monitoring or adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

VenoFlow may be worth considering if you're interested in supporting circulation and you don't take blood thinners, blood pressure medications, diabetes drugs, or immune suppressants. However, because of its significant interaction potential with blood thinners and other medication classes, this is one to clear with your doctor or pharmacist before you start—especially if you're on any cardiovascular or diabetes medication.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about VenoFlow, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870210238
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 232321
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for VenoFlow by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
737870210238
IngredientAmount% DV
Nattokinase0 NP--
VenoFlow Proprietary Blend200 mg--
Pycnogenol French Maritime Pine extract0 NP--

Other ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Dextrin, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) capsule daily, with or without food, or as recommended by a healthcare practitioner.

1 Daily

Precautions

Caution: Consult your healthcare provider before use if taking medication (especially those affecting blood coagulation or blood pressure), being treated for a medical condition (especially bleeding disorders), under the age of 18, pregnant or lactating.

Caution: Consult your healthcare provider before use if taking medication (especially those affecting blood coagulation or blood pressure), being treated for a medical condition (especially bleeding disorders), under the age of 18, pregnant or lactating.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Contains soybeans.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Storage

Store tightly closed in a cool, dry place.

Brand IP Statement(s)

Pycnogenol is a registered trademark of Horphag Research Ltd.

Seals/Symbols

Non GMO LE Certified

Formulation

Non GMO LE Certified

Promotes healthy venous blood flow

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

VenoFlow by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

VenoFlow label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in VenoFlow by Life Extension

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

VenoFlow Proprietary Blend

200 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Dextrin, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

VenoFlow by Life Extension Drug Interactions

Want to check YOUR meds against VenoFlow?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
494Drugs
494 Moderate

Ingredients driving the most interactions

Pycnogenol French Maritime Pine extract 327
Nattokinase 289

Individual Drug Interactions

The ingredients in VenoFlow interact with 494 drugs. Click any drug to see the details.

2 of the 2 ingredients in VenoFlow interact with drugs. Each result below shows which ingredient is responsible. Pycnogenol French Maritime Pine extract Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in VenoFlow with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pycnogenol French Maritime Pine extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Pycnogenol French Maritime Pine extract full monograph & interactions

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for VenoFlow, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

VenoFlow by Life Extension: Common Questions

Does VenoFlow by Life Extension interact with any medications?
Yes. Based on its ingredients, VenoFlow has a known interaction with 494 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
VenoFlow contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take VenoFlow if I'm on aspirin or warfarin?
No, not without talking to your doctor first. Nattokinase has blood-thinning effects and there's a reported case of brain bleeding in someone who combined nattokinase with aspirin. Pycnogenol also inhibits platelet aggregation. Your doctor needs to weigh the risks and may not recommend this product alongside blood thinners.
Is nattokinase safe if I have a soy allergy?
Nattokinase comes from fermented soybeans (natto). People sensitive to natto can have hypersensitivity reactions—including severe ones like anaphylaxis—with symptoms in the throat and mouth within 2 hours of ingestion. If you're sensitive to soy or natto, avoid this product.
Can I take this while pregnant?
Not nattokinase—there isn't enough safety data, so it's best avoided during pregnancy. Pycnogenol is rated possibly safe in pregnancy, but you should talk with your doctor or pharmacist to weigh the facts for your individual situation.
What is nattokinase, and what does it do?
Nattokinase is an enzyme from fermented soybeans that breaks down fibrin (a blood-clotting protein). It has thrombolytic and anticoagulant effects—meaning it can thin the blood. The evidence for its effectiveness in cardiovascular conditions isn't well established yet.
Does Pycnogenol actually work for leg circulation problems?
Pycnogenol (French Maritime Pine extract) is rated possibly effective for chronic venous insufficiency, a condition that affects blood flow in the veins. It's also rated possibly effective for osteoarthritis and asthma, but possibly ineffective for high cholesterol.
What are the most common side effects?
The most common side effects from Pycnogenol are gastrointestinal complaints, dizziness, and vertigo. Nattokinase is generally well tolerated short-term, but rare bleeding events have been reported. If you have a sensitivity to natto, hypersensitivity reactions can occur.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

VenoFlow label
Go deeper

The Full Monographs Behind VenoFlow’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph → Herb & supplement monograph

Maritime Pine

Interacts with 327 drugs

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...

Read the full Maritime Pine monograph →
Sources

Sources & How We Checked

VenoFlow's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Maritime Pine 14 references
  1. Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  2. Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
  3. Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
  4. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
  5. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
  6. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
  7. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
  8. Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
  9. Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
  10. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
  11. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
  12. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
  13. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
  14. Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

See these in context on the Maritime Pine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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