Arsenic Trioxide Injection shortage
Arsenic Trioxide Injection is currently listed in shortage by the FDA. The FDA lists 2 affected products. This page was last refreshed from FDA data on Sep 24, 2026.
Fresenius Kabi and Ingenus Pharmaceuticals are permanently stopping production of arsenic trioxide injection 1 mg/mL. Other makers — including Sandoz, Nexus Pharmaceuticals, Heritage Pharma, and Sagent — have not reported a shortage and still list arsenic trioxide injection in their supply.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available (see options).
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Arsenic Trioxide Injection. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
-
Sep 21, 2026Currently in shortage2 of 2 products affected.
-
Sep 21, 2026More presentations reported1 more product added to the shortage.
-
Feb 24, 2026First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Fresenius Kabi USA, LLC 📞 888-386-1300 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Arsenic Trioxide, Injection, 1 mg/1 mL (NDC 63323-637-10) | — | — | Discontinuation of the manufacture of the drug | — |
Manufacturer: Ingenus Pharmaceuticals LLC 📞 866-321-5031 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Arsenic Trioxide, Injection, 1 mg/1 mL (NDC 50742-438-10) | — | — | A business decision was made to discontinue manufacture of the drug. | — |
These rows are manufacturer reports to the FDA for Arsenic Trioxide Injection — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Arsenic Trioxide Injection? options further down this page.
Why is Arsenic Trioxide Injection in shortage?
Both Fresenius Kabi USA and Ingenus Pharmaceuticals have decided to permanently stop making their versions of Arsenic Trioxide Injection, 1 mg/1 mL. Fresenius Kabi described it as a discontinuation of manufacturing, and Ingenus stated it was a business decision to stop producing the drug. Neither company shared a more specific public reason for why they made that choice.
It's worth knowing that this report only covers these two manufacturers and their specific 1 mg/1 mL products. Other companies that make arsenic trioxide injection may be listed separately on this page and are not part of this particular report.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Arsenic Trioxide Injection, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Arsenic Trioxide Injection?
Arsenic Trioxide Injection is currently on the FDA drug-shortage list, and I want to walk you through what that means for you.
The affected strength is the 1 mg/1 mL injection. Right now, this strength has no available source from the two manufacturers on this shortage record — Fresenius Kabi and Ingenus. Both companies reported this as a business decision to discontinue making the product, so for these two makers the change may be permanent rather than a short pause.
That said, this report reflects only those two manufacturers. The same medicine — arsenic trioxide injection — is still listed on the market from several other companies, including some that make the 1 mg/mL strength (for example, Nexus, Sagent, Zydus, and others) and some that make a 2 mg/mL solution.
Here is what I suggest, in order:
- Do not stop, skip, or change any dose on your own. This is a treatment your care team manages closely.
- Ask your pharmacy or infusion center to check wholesalers and the other manufacturers listed above; the same medicine may be sourced from another maker, though it may not be in local stock.
- Because these two makers are discontinuing, talk with your prescriber about a clinician-chosen path forward.
Manufacturer contact numbers are listed on this page for reference; pharmacies usually handle those calls. This is national, manufacturer-reported data and may not match your local pharmacy's actual supply.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Where else can I get Arsenic Trioxide Injection?
FDA shortages are manufacturer-reported — a company only shows up on the shortage list if it told the FDA it has a supply problem, so not every maker of Arsenic Trioxide Injection is necessarily short. Below we pull together the other still-marketed options that are not reported in shortage: the same medicine from manufacturers that haven’t reported a problem, and alternative dosage forms. These may still be out of stock at your pharmacy, and only your prescriber or pharmacist can decide what’s right for you.
Same medicine, other manufacturers (not reported short)
Same active ingredient, dosage form & route as the shortage (matched on the FDB HICL ingredient code), from makers that have not filed a shortage with the FDA:
| Product | Strength | Form / route | Manufacturer | NDC |
|---|---|---|---|---|
| Arsenic Trioxide | ARSENIC TRIOXIDE 2 mg/mL | Injection, Solution · Intravenous | Sandoz Inc | 00781-3498-94 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 1 mg/mL | Injection · Intravenous | Nexus Pharmaceuticals LLC | 14789-0600-10 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 1 mg/mL | Injection · Intravenous | Heritage Pharma Labs Inc. d/b/a Avet Pharmaceuticals Inc | 23155-0869-41 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 2 mg/mL | Injection · Intravenous | Heritage Pharma Labs Inc. d/b/a Avet Pharmaceuticals Inc | 23155-0870-41 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 1 mg/mL | Injection · Intravenous | Sagent Pharmaceuticals | 25021-0226-10 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 2 mg/mL | Injection · Intravenous | Sagent Pharmaceuticals | 25021-0227-06 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 2 mg/mL | Injection, Solution · Intravenous | Eugia US LLC | 55150-0366-10 |
| Trisenox | ARSENIC TRIOXIDE 2 mg/mL | Injection, Solution · Intravenous | Cephalon, LLC | 63459-0601-06 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 1 mg/mL | Injection, Solution · Intravenous | Zydus Pharmaceuticals USA Inc. | 68382-0997-10 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 1 mg/mL | Injection, Solution · Intravenous | Nordic Pharma, Inc. | 69918-0720-02 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 1 mg/mL | Injection, Solution · Intravenous | Amneal Pharmaceuticals LLC | 70121-1483-07 |
| Arsenic Trioxide | ARSENIC TRIOXIDE 2 mg/mL | Injection, Solution · Intravenous | Amneal Pharmaceuticals LLC | 70121-1658-01 |
Therapeutic equivalents & pricing 15 productsclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Arsenic Trioxide 1 mg/mL | Nexus | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Heritage | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Sagent | 10 vials | — | AP | FDA listed |
| Arsenic trioxide 1 mg/mL | Zydus | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Ingenus | 1 vial | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Fresenius | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Gland | 10 vials | — | AP | FDA listed |
| Arsenic trioxide 1 mg/mL | Zydus | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Nordic | 2 vials | — | AP | Discontinued |
| Arsenic Trioxide 1 mg/mL | Amneal | 10 vials | — | AP | FDA listed |
| Arsenic trioxide 1 mg/mL | Zydus | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Novadoz | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Northstar | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Orbicular | 10 vials | — | AP | FDA listed |
| Arsenic Trioxide 1 mg/mL | Sintetica | 1 vial | — | AP | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Arsenic Trioxide Injection — that fall in the same broad treatment class (antineoplastics,miscellaneous) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other oncology shortages
Arsenic Trioxide Injection shortage FAQs
Is Arsenic Trioxide Injection in shortage?
Which products are affected?
When will Arsenic Trioxide Injection be available again?
Can I still get Arsenic Trioxide somewhere?
What should I do if I take Arsenic Trioxide Injection?
Still have a question about the Arsenic Trioxide Injection shortage?
Ask a pharmacist about this shortage →View Arsenic Trioxide Injection on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.