Betamethasone

27 interactions 1 explained in plain English
Also sold as: Betavet Celestone Soluspan Del-Beta Diprolene Luxiq Sernivo

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Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Levonorgestrel Intrauterine System Levonorgestrel Aspirin Rectal Ofloxacin Ofloxacin Otic
1 Contraindicated 19 Major 7 Moderate
All (27) Contraindicated (1) Major (19) Moderate (7)

Contraindicated

Betamethasone Desmopressin Nasal Concentraid® Increased risk of severe hyponatremia Details

Major

Betamethasone Aldesleukin Proleukin Reduced antitumor effectiveness Details Betamethasone Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Betamethasone Aspirin Rectal Aspirin An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Betamethasone Besifloxacin Ophthalmic Besivance An increased risk of tendon rupture Details Betamethasone Estradiol Delestrogen Increased corticosteroid effects Details Betamethasone Estradiol Topical Divigel Increased corticosteroid effects Details Betamethasone Estradiol Transdermal Patch Alora® Increased corticosteroid effects Details Betamethasone Gatifloxacin Ophthalmic Zymar® An increased risk of tendon rupture Details Betamethasone Gemifloxacin Factive An increased risk of tendon rupture Details Betamethasone Levofloxacin Levaquin An increased risk of tendon rupture Details Betamethasone Levofloxacin Injection Levaquin An increased risk of tendon rupture Details Betamethasone Levonorgestrel After banger Increased corticosteroid effects Details Betamethasone Levonorgestrel Intrauterine System Kyleena Increased corticosteroid effects Details Betamethasone Moxifloxacin Avelox An increased risk of tendon rupture Details Betamethasone Moxifloxacin Injection Avelox An increased risk of tendon rupture Details Betamethasone Moxifloxacin Ophthalmic Moxeza® An increased risk of tendon rupture Details Betamethasone Ofloxacin Floxin® An increased risk of tendon rupture Details Betamethasone Ofloxacin Ophthalmic Ocuflox An increased risk of tendon rupture Details Betamethasone Ofloxacin Otic Floxin® Otic An increased risk of tendon rupture Details

Moderate

Betamethasone Apixaban Eliquis Explained Increased risk of gastrointestinal bleeding Details Betamethasone Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Betamethasone Dabigatran Pradaxa® Increased risk of gastrointestinal bleeding Details Betamethasone Dabigatran Etexilate Increased risk of gastrointestinal bleeding Details Betamethasone Edoxaban Savaysa Increased risk of gastrointestinal bleeding Details Betamethasone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Betamethasone Olodaterol Oral Inhalation Striverdi An increased risk of hypokalemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.