Furosemide

105 interactions 5 explained in plain English

Also sold as: Disal Furoscix Lasix Salix - substance

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Cefotetan Injection Diclofenac Topical (Arthritis Pain) Ketorolac Meloxicam Perindopril

1 Contraindicated 88 Major 15 Moderate 1 Minor

All (105) Contraindicated (1) Major (88) Moderate (15) Minor (1)

Major

Furosemide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related toxicity, altered (increased/reduced) furosemide exposu... Details Furosemide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related toxicity, altered (increased/reduced) furosemide exposu... Details Furosemide Miglitol Glyset® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Moexipril Univasc® An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Furosemide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Furosemide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Nateglinide Starlix® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Perindopril Aceon An increased risk of severe hypotension and deterioration in renal function, including renal failure Details

Moderate

Furosemide Aliskiren Tekturna Decreased furosemide exposure Details Furosemide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Furosemide Cholestyramine Resin Locholest® Decreased furosemide effectiveness Details Furosemide Colestipol Colestid Decreased furosemide effectiveness Details Furosemide Cyclosporine Injection Atopica Increased risk of gouty arthritis secondary to furosemide-induced hyperuricemia and cyclosporine impairment of renal urate excreti... Details Furosemide Cyclosporine Ophthalmic Cequa Increased risk of gouty arthritis secondary to furosemide-induced hyperuricemia and cyclosporine impairment of renal urate excreti... Details Furosemide Digoxin Cardoxin® Increased risk of digoxin toxicity (nausea, vomiting, cardiac arrhythmias) Details Furosemide Dofetilide Tikosyn An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Furosemide Fludrocortisone Acetate Florinef® Hypokalemia Details Furosemide Hydrocortisone Ala-Cort Hypokalemia Details Furosemide Hydrocortisone Injection A-Hydrocort® Hypokalemia Details Furosemide Mesalamine Apriso An increased risk of salicylate toxicity Details Furosemide Mesalamine Rectal Canasa An increased risk of salicylate toxicity Details Furosemide Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Furosemide Olodaterol Oral Inhalation Striverdi An increased risk of ECG changes and/or an increased risk of hypokalemia Details

Minor

Furosemide Hydralazine Apresoline® An enhanced diuretic response to furosemide Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.