Hexobarbital

23 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Hydromorphone Injection Amitriptyline Metoclopramide Injection Hydromorphone Rectal Nalbuphine Injection Cetirizine Injection
20 Major 3 Moderate
All (23) Major (20) Moderate (3)

Major

Hexobarbital Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Hexobarbital Amitriptyline Elavil Explained Reduced tricyclic antidepressant exposure and possible additive adverse effects Details Hexobarbital Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Hexobarbital Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Hexobarbital Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Hexobarbital Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Hexobarbital Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Hexobarbital Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Hexobarbital Diazepam Rectal Diastat Increased risk of CNS depression Details Hexobarbital Doxycycline Injection Acticlate Reduced doxycycline exposure and reduced efficacy of doxycycline Details Hexobarbital Esketamine Nasal Spray Spravato Increased risk of sedation Details Hexobarbital Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Hexobarbital Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Hexobarbital Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Hexobarbital Lacosamide Injection Motpoly An increased risk of CNS depression Details Hexobarbital Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Hexobarbital Metoclopramide Injection Gimoti Increased risk of CNS depression Details Hexobarbital Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Hexobarbital Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Hexobarbital Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.