Proguanil

Name: Proguanil Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

7 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Exenatide Injection Hydroxychloroquine Methotrexate Methotrexate Injection

4 Major 3 Moderate

All (7) Major (4) Moderate (3)

Major

Proguanil Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Proguanil Hydroxychloroquine Plaquenil An increased risk of seizures Details Proguanil Methotrexate Jylamvo Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Proguanil Methotrexate Injection Abitrexate® Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details

Moderate

Proguanil Lanthanum Fosrenol® Reduced bioavailability of antimalarials Details Proguanil Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details Proguanil Mitapivat Aqvesme Reduced CYP2C19 substrate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.