Suvorexant
40 interactions 5 explained in plain English
Also sold as:
Belsomra
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Colchicine
Cetirizine Ophthalmic
Cyclosporine Injection
Lacosamide Injection
Nifedipine
Butorphanol Injection
Major
Suvorexant Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Suvorexant Abametapir Explained Increased exposure of CYP3A4 substrate Details Suvorexant Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Suvorexant Relugolix Orgovyx Explained Increased relugolix exposure Details Suvorexant Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Suvorexant Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Suvorexant Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Suvorexant Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Suvorexant Cyclosporine Injection Atopica Increased cycloSPORINE exposure and increased suvorexant exposure Details Suvorexant Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and increased suvorexant exposure Details Suvorexant Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Suvorexant Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Suvorexant Digoxin Cardoxin® Increased digoxin exposure and an increased risk of digoxin-related adverse reaction Details Suvorexant Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Suvorexant Esketamine Nasal Spray Spravato Increased risk of sedation Details Suvorexant Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Suvorexant Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Suvorexant Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Suvorexant Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Suvorexant Ketoconazole Topical Extina® Foam Increased suvorexant exposure and an increased risk of suvorexant-related adverse effects Details Suvorexant Lacosamide Injection Motpoly An increased risk of CNS depression Details Suvorexant Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Suvorexant Letermovir Injection Prevymis Increased suvorexant exposure Details Suvorexant Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Suvorexant Loperamide Diamode An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Suvorexant Methylergonovine Methergine Increased methylergonovine exposure Details Suvorexant Metoclopramide Injection Gimoti Increased risk of CNS depression Details Suvorexant Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Suvorexant Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma, increased morphine exposure and an increased risk... Details Suvorexant Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Suvorexant Nifedipine Adalat® Increased NIFEdipine exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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