Suvorexant

Name: Suvorexant Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

40 interactions 5 explained in plain English

Also sold as: Belsomra

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Cetirizine Ophthalmic Cyclosporine Injection Lacosamide Injection Nifedipine Butorphanol Injection

1 Contraindicated 31 Major 8 Moderate

All (40) Contraindicated (1) Major (31) Moderate (8)

Moderate

Suvorexant Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Suvorexant Diphenhydramine Injection Banophen Additive sedative effects Details Suvorexant Diphenhydramine Topical Afterbite with Antihistamine Additive sedative effects Details Suvorexant Dofetilide Tikosyn Increased dofetilide exposure Details Suvorexant Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Suvorexant Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Suvorexant Midazolam Nasal Spray Nayzilam Additive sedative effects Details Suvorexant Midazolam Injection Nayzilam Additive sedative effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.