Drug & supplement interaction

1,4-dmaa + Memantine

Memantine brand name: Ebixa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between 1,4-dmaa and Memantine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

1,4-dmaa and Memantine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Memantine and 1,4-dmaa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

1,4-dmaa safety at a glance

1,4-dmaa overall Avoid Banned by the FDA and tied to serious cardiovascular harm; avoid use.
Pregnancy Avoid Not safe; powerful stimulants should be avoided during pregnancy.
Breastfeeding Avoid Not safe; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Memantine and 1,4-dmaa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Memantine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Memantine is filed under 2 classifications — nmda antagonists, oral drugs. 1,4-dmaa has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Memantine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

1,4-dmaa Does Interact With Other Medications

1,4-dmaa has 172 moderate known drug interactions in our database — Memantine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Memantine)
Taking anything else?

Check Another of Your Medications Against 1,4-dmaa

Covers the 2,830 medications we’ve checked against 1,4-dmaa. Pick one to open its full report.

What to actually watch for

What 1,4-dmaa Itself Has Been Linked To

This is not an interaction — nothing below involves Memantine. It is the side-effect record for 1,4-dmaa on its own, from the licensed Natural Medicines monograph. If something new turns up after you add 1,4-dmaa, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A stroke or mini-stroke Worth acting on Additional detail

    “Orally, clinical evidence on the safety of 1,4-DMAA is lacking, although it has demonstrated stimulant and vasoconstrictive effects in animal studies. A related stimulant called 1,3-DMAA has been linked to serious adverse events in humans, including lactic acidosis, hemorrhagic stroke, heat stroke, and death.”

    1,4-dmaa · Natural Medicines adverse-effect record, reported in stroke.

    6 sources cited
    1. 100692. Cohen PA, Travis JC, Keizers PHJ, Deuster P, Venhuis BJ. Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbuty
    2. 17599. Vorce SP, Holler JM, Cawrse BM, Magluilo J. Dimethylamylamine: A drug causing positive immunoassay results for amphetamines. J Anal Toxicol 2011;35:183-7. PubMed
    3. 17660. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
    4. 17662. Starling S. Synthetic geranium substance raises ephedra-like red flags. Nutraingredients-use.com, May 11, 2010. Available at: http://www.nutraingredients-usa.com/Industry/Synthetic-geranium-substance-raises-ephedra-like-red-flags. (Accessed 12 August 2011
    5. 17663. Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7.
    6. 17904. Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: http://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).

Everything above comes from the Natural Medicines adverse-effect record for 1,4-dmaa — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Memantine’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Memantine column appears here.

Everything else you take

See Every Supplement That Interacts With Memantine

This page covers 1,4-dmaa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Memantine page lists 18 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Threonine (major), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 2 major · 7 moderate · 9 minor.

Open the Memantine interaction page

How much people look this up

Where 1,4-dmaa and Memantine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 1,4-dmaa
Steady interest

#765 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Memantine
Steady interest

#1,625 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 1,4-dmaa reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The 1,4-dmaa and Memantine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 1,4-dmaa

What is 1,4-dmaa?

  • Energy and stimulation
  • Weight loss
  • Athletic performance
  • Focus and concentration

1,4-DMAA is a synthetic stimulant that the U.S. FDA has determined is not a legal dietary ingredient and considers unsafe in supplements. It has been linked to serious heart and blood pressure problems, and we recommend avoiding it entirely.

Synthetic chemical (not a true plant part) · Capsules, tablets, pre-workout powders

An interaction check asks whether these two react with each other — it does not ask whether 1,4-dmaa is a good idea for someone in your situation. Here is what our 1,4-dmaa record says about it on its own.

1,4-dmaa: dosing

There is no safe or established dose of 1,4-DMAA, and it is not a legal dietary ingredient in the United States. We do not recommend any amount.If you find a product that lists DMAA, 1,4-DMAA, or similar stimulant names on the label, do not take it, and consider reporting it.

From our 1,4-dmaa monograph — the full record covers uses, side effects and every documented interaction.

Read the full 1,4-dmaa monograph & all interactions
Medication

About Memantine

What Is Memantine Used For?

Brand name: Ebixa

Memantine treats moderate to severe dementia of the Alzheimer's type. It is available as tablets, extended-release capsules, and an oral solution — all approved for this same use.

It does not cure Alzheimer's disease and is not shown to prevent or slow the underlying loss of brain cells. It is used to help manage symptoms of moderate to severe disease.

See full Memantine drug information
Keep checking

Other Drugs & 1,4-dmaa

Browse every other medication we’ve checked against 1,4-dmaa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the 1,4-dmaa page.

No interaction 2,657 drugs checked — show the list

We also checked 1,4-dmaa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full 1,4-dmaa list.

See the full 1,4-dmaa interactions page
See every supplement checked against Memantine, ranked by severity
Evidence & sources

1,4-dmaa References

The 9 references that drive our 1,4-dmaa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Vorce SP, Holler JM, Cawrse BM, Magluilo J. Dimethylamylamine: A drug causing positive immunoassay results for amphetamines. J Anal Toxicol 2011;35:183-7. PubMed
  2. Adverse Event Report. Jack3d. Natural MedWatch, May 28, 2011.
  3. Starling S. Synthetic geranium substance raises ephedra-like red flags. Nutraingredients-use.com, May 11, 2010. Available at: http://www.nutraingredients-usa.com/Industry/Synthetic-geranium-substance-raises-ephedra-like-red-flags. (Accessed 12 August 2011
  4. Gee P, Jackson S, Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N Z Med J 2010;123:124-7.
  5. Removal of the dietary supplement DMAA. Army Medicine, Office of the Surgeon General, 2011. Available at: http://humanperformanceresourcecenter.org/dietary-supplements/files/dmaa-pdf. (Accessed 4 January 2012).
  6. Archer JR, Dargan PI, Lostia AM, van der Walt J, Henderson K, Drake N, Sharma S, Wood DM, Walker CJ, Kicman AT. Running an unknown risk: a marathon death associated with the use of 1,3-dimethylamylamine (DMAA). Drug Test Anal. 2015 May;7(5):433-8. PubMed
  7. Eliason MJ, Eichner A, Cancio A, Bestervelt L, Adams BD, Deuster PA. Case reports: Death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA). Mil Med. 2012 Dec;177(12):1455-9. PubMed
  8. Palmer PG Jr. Deadly dimethylamylamine: "health" supplements are killing consumers while current regulations impede FDA action. J Leg Med. 2014;35(2):311-36. PubMed
  9. Cohen PA, Travis JC, Keizers PHJ, Deuster P, Venhuis BJ. Four experimental stimulants found in sports and weight loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbuty

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 1,4-dmaa and Memantine Together: Common Questions

Is it safe to take 1,4-dmaa with Memantine?
We do not list a known interaction between 1,4-dmaa and Memantine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 1,4-dmaa and Memantine combination checked?
Interactions in our licensed database are recorded against drug classes. Memantine is filed under 2 classifications, and 1,4-dmaa has documented interactions with 1 drug class — none of Memantine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 1,4-dmaa interact with any other medications?
Yes. 1,4-dmaa has 172 documented drug interactions in our database — Memantine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Memantine interact with any supplements?
Yes. Memantine has documented interactions with 18 supplements in our database — 1,4-dmaa is not one of them. The Memantine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

1,4-dmaa monograph Uses, safety profile, and every drug interaction in one place Memantine drug information The full plain-English guide to this medication Memantine supplement interactions Every supplement checked against Memantine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Memantine and 1,4-dmaa?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.