Drug & supplement interaction

4-androsterone + Lansoprazole

Lansoprazole brand name: Prevacid.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 4-androsterone and Lansoprazole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

4-androsterone and Lansoprazole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Lansoprazole and 4-androsterone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

4-androsterone safety at a glance

4-androsterone overall Use caution Prohormones can disrupt hormones, strain the liver, and affect cholesterol; safety is not well studied.
Pregnancy Avoid Androgenic hormones can harm a developing baby; do not use during pregnancy.
Breastfeeding Avoid Hormonal effects on a nursing infant are unknown and potentially harmful; avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Lansoprazole and 4-androsterone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Lansoprazole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Lansoprazole is filed under 5 classifications — including proton pump inhibitors (ppis), cytochrome p450 1a2 (cyp1a2) inducers, cytochrome p450 2c19 (cyp2c19) substrates. 4-androsterone has documented interactions with 1 drug class — the most serious being testosterone (moderate) — and none of Lansoprazole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

4-androsterone Does Interact With Other Medications

4-androsterone has 8 moderate known drug interactions in our database — Lansoprazole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 8 No known interaction 2,822 (incl. Lansoprazole)
Taking anything else?

Check Another of Your Medications Against 4-androsterone

Covers the 2,830 medications we’ve checked against 4-androsterone. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests 4-androsterone and Lansoprazole May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Kidney problems / Liver problems Worth acting on reported in 42.3% of FDA reports for Lansoprazole Additional detail

    4-androsterone

    “There is insufficient information available about adverse effects associated with 4-androsterone. It is purported that 4-androsterone is metabolized to anabolic compounds. Therefore, in theory, there is concern that it might cause serious anabolic steroid-like side effects including stroke, kidney failure, and liver injury.”

    4-androsterone · Natural Medicines adverse-effect record, reported in kidney failure.

    Lansoprazole

    Listed in the ADVERSE REACTIONS section of the FDA label for Lansoprazole, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Lansoprazole come from the ADVERSE REACTIONS section of its FDA label; effects for 4-androsterone come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 177,063 voluntary FDA FAERS reports for Lansoprazole that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About 4-androsterone or Lansoprazole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 4-androsterone or Lansoprazole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Lansoprazole

This page covers 4-androsterone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lansoprazole page lists 153 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 101 moderate · 49 minor.

From our pharmacist’s overview on the Lansoprazole page

“Heartburn and reflux send plenty of people toward both lansoprazole (Prevacid) and the supplement aisle, and that pairing calls for genuine care, since three of the 153 ingredients on file here carry major-rated interactions. Most of the list works through the liver enzymes that clear lansoprazole, either slowing them down (grapefruit,…”

Reviewed by 2 · Jul 18, 2026

Open the Lansoprazole interaction page

One more smart check

Taking 4-androsterone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 23 real supplement products containing 4-androsterone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 4-androsterone. Even though 4-androsterone itself has no known interaction with Lansoprazole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 4-androsterone and Lansoprazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 4-androsterone
Steady interest

#994 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lansoprazole
Top half

#982 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. 4-androsterone is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 4-androsterone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 4-androsterone and Lansoprazole records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 4-androsterone

What is 4-androsterone?

  • Muscle building
  • Strength and athletic performance
  • Boosting testosterone
  • Bodybuilding cycles

4-Androsterone (sometimes called 4-DHEA) is a lab-made prohormone marketed to bodybuilders as a way to raise testosterone and build muscle, but human studies are very limited and it carries real risks like liver strain, hormone imbalance, and cholesterol changes. Its legal status is uncertain in many places, and it may cause a positive result on drug tests. We do not recommend it without close medical supervision, and it should be avoided in pregnancy and breastfeeding.

Synthetic steroidal compound (not a plant part) · Capsules, tablets, transdermal gels or creams, liquid drops

An interaction check asks whether these two react with each other — it does not ask whether 4-androsterone is a good idea for someone in your situation. Here is what our 4-androsterone record says about it on its own.

4-androsterone: dosing

There is no established, medically recommended dose for 4-androsterone. Doses used in bodybuilding come from product labels and informal community advice, not from rigorous clinical research.Because purity and strength can vary between products and the risks are significant, we cannot recommend a specific amount. Never assume that a higher dose is safer or more effective.

From our 4-androsterone monograph — the full record covers uses, side effects and every documented interaction.

Read the full 4-androsterone monograph & all interactions
Medication

About Lansoprazole

What Is Lansoprazole Used For?

Brand name: Prevacid

Lansoprazole is prescribed for a range of conditions where excess stomach acid is the problem. It treats active stomach and duodenal ulcers (sores in the stomach or upper small intestine), helps heal ulcers caused by NSAID pain relievers, and can reduce the risk of those ulcers coming back.

It's also used for gastroesophageal reflux disease (GERD), erosive esophagitis (acid damage to the esophagus), and rare conditions where the stomach makes far too much acid — like Zollinger-Ellison syndrome. When combined with antibiotics, it helps wipe out H. pylori bacteria that cause recurring ulcers.

Most-Reported Side Effects for Lansoprazole

From FAERS, the FDA’s public side-effect reporting system (177,063 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Chronic kidney disease 32,791 reports
Acute kidney injury 18,792 reports
Renal failure 13,844 reports
End stage renal disease 9,798 reports
Renal injury 9,520 reports
See full Lansoprazole drug information
Keep checking

Other Drugs & 4-androsterone

Browse every other medication we’ve checked against 4-androsterone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
8Moderate
0Minor
2,821No known interaction
8 Moderate 2,821 No interaction
Moderate

8 interactions

No interaction 2,821 drugs checked — show the list

We also checked 4-androsterone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,821 medications checked with no known interaction — see the full 4-androsterone list.

See the full 4-androsterone interactions page
See every supplement checked against Lansoprazole, ranked by severity
Evidence & sources

4-androsterone References

The 3 sources that drive our 4-androsterone monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. 4-androsterone is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Anabolic Steroids and Other Appearance and Performance Enhancing Drugs (APEDs) — NIH National Institute on Drug Abuse Source
  2. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  3. DHEA — MedlinePlus Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 4-androsterone and Lansoprazole Together: Common Questions

Is it safe to take 4-androsterone with Lansoprazole?
We do not list a known interaction between 4-androsterone and Lansoprazole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do 4-androsterone and Lansoprazole have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the 4-androsterone and Lansoprazole combination checked?
Interactions in our licensed database are recorded against drug classes. Lansoprazole is filed under 5 classifications, and 4-androsterone has documented interactions with 1 drug class — none of Lansoprazole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 4-androsterone interact with any other medications?
Yes. 4-androsterone has 8 documented drug interactions in our database — Lansoprazole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Lansoprazole interact with any supplements?
Yes. Lansoprazole has documented interactions with 153 supplements in our database — 4-androsterone is not one of them. The Lansoprazole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

4-androsterone monograph Uses, safety profile, and every drug interaction in one place Lansoprazole drug information The full plain-English guide to this medication Lansoprazole supplement interactions Every supplement checked against Lansoprazole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Lansoprazole and 4-androsterone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.