Drug & supplement interaction

Acetyl-l-carnitine + Entrectinib

Entrectinib brand name: Rozlytrek.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Acetyl-l-carnitine and Entrectinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Acetyl-l-carnitine and Entrectinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Entrectinib and Acetyl-l-carnitine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Acetyl-l-carnitine safety at a glance

Acetyl-l-carnitine overall Use caution Generally well tolerated short-term, but long-term safety is not fully established.
Pregnancy Avoid There is not enough reliable safety information, so it is best avoided unless your doctor advises otherwise.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoiding it is the safer choice.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Entrectinib and Acetyl-l-carnitine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Entrectinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Entrectinib is filed under 4 classifications — including qt interval-prolonging drugs, hepatotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Acetyl-l-carnitine has documented interactions with 4 drug classes — the most serious being acenocoumarol (sintrom) (moderate), serotonergic drugs (moderate) and thyroid hormone (moderate) — and none of Entrectinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Acetyl-l-carnitine Does Interact With Other Medications

Acetyl-l-carnitine has 203 moderate known drug interactions in our database — Entrectinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 203 No known interaction 2,627 (incl. Entrectinib)
Taking anything else?

Check Another of Your Medications Against Acetyl-l-carnitine

Covers the 2,830 medications we’ve checked against Acetyl-l-carnitine. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Acetyl-l-carnitine and Entrectinib May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Confusion / Low mood Worth acting on Additional detail

    Acetyl-l-carnitine

    “Orally, acetyl-L-carnitine may cause agitation (restlessness and motor overactivity). Side effects reported in people with Alzheimer disease include psychiatric disturbances such as depression, mania, confusion and aggression, but it is not clear whether these are due to acetyl-L-carnitine or the condition itself.”

    Acetyl-l-carnitine · Natural Medicines adverse-effect record, reported in alzheimer disease.

    6 sources cited
    1. 1596. Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. Neurology 1991;41:1726-32. PubMed
    2. 1599. Rai G, Wright G, Scott L, et al. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Curr Med Res Opin 1990;11:638-47. PubMed
    3. 12743. De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study. Drugs R D 2002;3:223-31. PubMed
    4. 13007. Sima AAF, Calvani M, Mehra M, et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized, placebo-controlled trials. Diabetes Care 2005;28:89-94.
    5. 1594. Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. Neurology 1996;47:705-11. PubMed
    6. 1595. Sano M, Bell K, Cote L, et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. Arch Neurol 1992;49:1137-41. PubMed

    Entrectinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Entrectinib. Read the label on DailyMed ›

  • Mood changes or irritability / Numbness or tingling Additional detail

    Acetyl-l-carnitine

    “Orally, acetyl-L-carnitine may cause headache and insomnia. In one clinical trial, two patients with antiretroviral toxic neuropathy reported paresthesia, pain, and neuropathy after taking acetyl-L-carnitine 1000 mg daily. A case of mania has been reported for a patient with bipolar I disorder currently in remission.”

    Acetyl-l-carnitine · Natural Medicines adverse-effect record, reported in bipolar disorder.

    5 sources cited
    1. 90760. Ledinek AH, Sajko MC, Rot U. Evaluating the effects of amantadin, modafinil and acetyl-L-carnitine on fatigue in multiple sclerosis--result of a pilot randomized, blind study. Clin Neurol Neurosurg. 2013 Dec;115 Suppl 1:S86-9. PubMed
    2. 90767. Martinotti G, Andreoli S, Reina D, Di Nicola M, Ortolani I, Tedeschi D, Fanella F, Pozzi G, Iannoni E, D'Iddio S, Prof LJ. Acetyl-l-Carnitine in the treatment of anhedonia, melancholic and negative symptoms in alcohol dependent subjects. Prog Neuropsychop PubMed
    3. 95063. Bruno A, Pandolfo G, Crucitti M, Lorusso S, Zoccali RA, Muscatello MR. Acetyl-L-Carnitine Augmentation of Clozapine in Partial-Responder Schizophrenia: A 12-Week, Open-Label Uncontrolled Preliminary Study. Clin Neuropharmacol. 2016;39(6):277-80. PubMed
    4. 58342. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV.Med. 2007;8(4):241-250.
    5. 95062. Goodison G, Overeem K, de Monte V, Siskind D. Mania associated with self-prescribed acetyl-l-carnitine in a man with bipolar I disorder. Australas Psychiatry. 2017;25(1):13-4.

    Entrectinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Entrectinib. Read the label on DailyMed ›

  • Constipation / Stomach upset / Diarrhea reported in 4.0% of FDA reports for Entrectinib Additional detail

    Acetyl-l-carnitine

    “Orally, acetyl-L-carnitine may cause nausea, vomiting, diarrhea, constipation, hiccups, abdominal distension and gastrointestinal upset or pain. However, gastrointestinal symptoms do not usually occur more often in patients receiving acetyl-L-carnitine than in patients receiving placebo. Acetyl-L-carnitine may also cause dry mouth and anorexia.”

    Acetyl-l-carnitine · Natural Medicines adverse-effect record, reported in anorexia.

    2 sources cited
    1. 58342. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV.Med. 2007;8(4):241-250.
    2. 90441. Brennan BP, Jensen JE, Hudson JI, Coit CE, Beaulieu A, Pope HG Jr, Renshaw PF, Cohen BM. A placebo-controlled trial of acetyl-L-carnitine and a-lipoic acid in the treatment of bipolar depression. J Clin Psychopharmacol. 2013 Oct;33(5):627-35.

    Entrectinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Entrectinib, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Anxiety or restlessness Additional detail

    Acetyl-l-carnitine

    “Orally, acetyl-L-carnitine is generally well tolerated.

    Most Common Adverse Effects:

    Orally: Agitation, dry mouth, headache, insomnia, and reduced appetite. A metabolite of acetyl-L-carnitine has been reported to cause a fishy odor of the urine, breath, and sweat.”

    Acetyl-l-carnitine · Natural Medicines adverse-effect record, reported in cluster headache.

    Entrectinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Entrectinib. Read the label on DailyMed ›

  • Reduced appetite Additional detail

    Acetyl-l-carnitine

    Recorded for Acetyl-l-carnitine in the same Natural Medicines adverse-effect record shown under Anxiety or restlessness above.

    Entrectinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Entrectinib. Read the label on DailyMed ›

  • Trouble sleeping Additional detail

    Acetyl-l-carnitine

    Recorded for Acetyl-l-carnitine in the same Natural Medicines adverse-effect record shown under Anxiety or restlessness above.

    Entrectinib

    Listed in the ADVERSE REACTIONS section of the FDA label for Entrectinib. Read the label on DailyMed ›

Showing the 10 most notable of 13 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Acetyl-l-carnitine but not commonly for Entrectinib: bloating or gas, raised blood pressure, mania or an unusually elevated mood and dry mouth.

Effects for Entrectinib come from the ADVERSE REACTIONS section of its FDA label; effects for Acetyl-l-carnitine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,653 voluntary FDA FAERS reports for Entrectinib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Entrectinib

This page covers Acetyl-l-carnitine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Entrectinib page lists 175 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Beer (major) and Cesium (major).

By severity: 11 major · 127 moderate · 37 minor.

From our pharmacist’s overview on the Entrectinib page

“Grapefruit tops my worry list for anyone taking entrectinib (Rozlytrek), a targeted cancer therapy cleared by the liver enzyme CYP3A4. 121 of the 175 supplement ingredients on this page can shift how that enzyme handles the drug.”

Reviewed by 2 · Jul 18, 2026

Open the Entrectinib interaction page

One more smart check

Taking Acetyl-l-carnitine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 405 real supplement products containing Acetyl-l-carnitine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Acetyl-l-carnitine. Even though Acetyl-l-carnitine itself has no known interaction with Entrectinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Acetyl-l-carnitine and Entrectinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Acetyl-l-carnitine
Top 10%

#94 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Entrectinib
Top 25%

#451 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Acetyl-l-carnitine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Acetyl-l-carnitine and Entrectinib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Acetyl-l-carnitine

What is Acetyl-l-carnitine?

Acetyl-l-carnitine
  • Memory and cognitive support
  • Nerve pain (neuropathy)
  • Energy and fatigue
  • Age-related decline
  • Male fertility
  • Mood support

Acetyl-L-carnitine is a form of the amino acid carnitine that the body uses to help produce energy in cells. It is most studied for nerve pain and memory-related conditions, though the evidence is mixed and often limited. It is generally well tolerated for short-term use, but you should talk with your pharmacist or doctor before starting it.

Not applicable (a naturally occurring compound made in the body) · Capsules, tablets, powder, and liquid

An interaction check asks whether these two react with each other — it does not ask whether Acetyl-l-carnitine is a good idea for someone in your situation. Here is what our Acetyl-l-carnitine record says about it on its own.

Acetyl-l-carnitine: dosing

There is no single official dose of Acetyl-L-carnitine for any condition. Taking it with food may help reduce stomach upset. Do not assume that taking more will work better, as higher amounts can increase the chance of side effects.

From our Acetyl-l-carnitine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Acetyl-l-carnitine monograph & all interactions
Medication

About Entrectinib

What Is Entrectinib Used For?

Brand name: Rozlytrek

Rozlytrek (entrectinib) is used to treat adult patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC), as confirmed by an FDA-approved test. It is also approved for adult and pediatric patients older than 1 month of age who have solid tumors — any cancer type — that carry an NTRK gene fusion detected by an FDA-approved test, provided the tumor has no known acquired resistance mutation, is metastatic or cannot be surgically removed without severe harm, and has progressed after prior treatment or has no satisfactory alternative therapy.

The NTRK gene fusion approval in solid tumors was granted under accelerated approval, meaning it is based on tumor response rates. Continued approval may depend on results from confirmatory clinical trials.

Most-Reported Side Effects for Entrectinib

From FAERS, the FDA’s public side-effect reporting system (1,653 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dizziness 150 reports
Disease progression 117 reports
Taste disorder 71 reports
Constipation 66 reports
Blood creatinine increased 62 reports
See full Entrectinib drug information
Keep checking

Other Drugs & Acetyl-l-carnitine

Browse every other medication we’ve checked against Acetyl-l-carnitine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
203Moderate
0Minor
2,626No known interaction
203 Moderate 2,626 No interaction
Moderate

203 interactions

Showing 60 of 203 moderate interactions — see all 203 on the Acetyl-l-carnitine page.

No interaction 2,626 drugs checked — show the list

We also checked Acetyl-l-carnitine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,626 medications checked with no known interaction — see the full Acetyl-l-carnitine list.

See the full Acetyl-l-carnitine interactions page
See every supplement checked against Entrectinib, ranked by severity
Evidence & sources

Acetyl-l-carnitine References

The 22 references that drive our Acetyl-l-carnitine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's Disease. Neurology 1996;47:705-11. PubMed
  2. Sano M, Bell K, Cote L, et al. Double-blind parallel design pilot study of acetyl levocarnitine in patients with Alzheimer's Disease. Arch Neurol 1992;49:1137-41. PubMed
  3. Spagnoli A, Lucca U, Menasce G, et al. Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. Neurology 1991;41:1726-32. PubMed
  4. Brooks JO 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int Psychoger 1998;10:193-203. PubMed
  5. Pettegrew JW, Klunk WE, Panchalingam K, et al. Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease. Neurobiol Aging 1995;16:1-4. PubMed
  6. Rai G, Wright G, Scott L, et al. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Curr Med Res Opin 1990;11:638-47. PubMed
  7. Benvenga S, Ruggeri RM, Russo A, et al. Usefulness of L-carnitine, a naturally occurring peripheral antagonist of thyroid hormone action, in iatrogenic hyperthyroidism: a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Meta
  8. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carnitine versus placebo in the treatment of mild cognitive impairment and mild Alzheimer's disease. Int Clin Psychopharmacol 2003;18:61-71.. PubMed
  9. Martinez E, Domingo P, Roca-Cusachs A. Potentiation of acenocoumarol action by L-carnitine. J Intern Med 1993;233:94.
  10. Hudson S, Tabet N. Acetyl-L-carnitine for dementia. Cochrane Database Syst Rev 2003;2:CD003158.. PubMed
  11. Bachmann HU, Hoffmann A. Interaction of food supplement L-carnitine with oral anticoagulant acenocoumarol. Swiss Med Wkly 2004;134:385. PubMed
  12. De Grandis D, Minardi C. Acetyl-L-carnitine (levacecarnine) in the treatment of diabetic neuropathy. A long-term, randomised, double-blind, placebo-controlled study. Drugs R D 2002;3:223-31. PubMed
  13. 12761 Benvenga S, Amato A, Calvani M, Trimarchi F. Effects of carnitine on thyroid hormone action. Ann N Y Acad Sci 2004;1033:158-67. PubMed
  14. Sima AAF, Calvani M, Mehra M, et al. Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: An analysis of two randomized, placebo-controlled trials. Diabetes Care 2005;28:89-94.
  15. Youle, M. and Osio, M. A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. HIV.Med. 2007;8(4):241-250.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Acetyl-l-carnitine and Entrectinib Together: Common Questions

Is it safe to take Acetyl-l-carnitine with Entrectinib?
We do not list a known interaction between Acetyl-l-carnitine and Entrectinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Acetyl-l-carnitine and Entrectinib have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Acetyl-l-carnitine and Entrectinib combination checked?
Interactions in our licensed database are recorded against drug classes. Entrectinib is filed under 4 classifications, and Acetyl-l-carnitine has documented interactions with 4 drug classes — none of Entrectinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Acetyl-l-carnitine interact with any other medications?
Yes. Acetyl-l-carnitine has 203 documented drug interactions in our database — Entrectinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Entrectinib interact with any supplements?
Yes. Entrectinib has documented interactions with 175 supplements in our database — Acetyl-l-carnitine is not one of them. The Entrectinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Acetyl-l-carnitine monograph Uses, safety profile, and every drug interaction in one place Entrectinib drug information The full plain-English guide to this medication Entrectinib supplement interactions Every supplement checked against Entrectinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Entrectinib and Acetyl-l-carnitine?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.