Drug & supplement interaction

Adrue + Pentosan Polysulfate Sodium

Pentosan Polysulfate Sodium brand name: Elmiron.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated June 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Adrue and Pentosan Polysulfate Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Adrue and Pentosan Polysulfate Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pentosan Polysulfate Sodium and Adrue in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Adrue safety at a glance

Adrue overall Not established Human safety data are very limited, so use cautiously and under professional guidance.

Pregnancy Avoid Not enough safety information; avoid during pregnancy.

Breastfeeding Avoid No reliable safety data; avoid while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pentosan Polysulfate Sodium and Adrue? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Pentosan Polysulfate Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pentosan Polysulfate Sodium is filed under a single classification — oral drugs. Adrue has documented interactions with 3 drug classes — the most serious being barbiturates (moderate), benzodiazepines (moderate) and cns depressants (moderate) — and none of Pentosan Polysulfate Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Adrue Does Interact With Other Medications

Adrue has 256 moderate known drug interactions in our database — Pentosan Polysulfate Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 256 No known interaction 2,574 (incl. Pentosan Polysulfate Sodium)

Taking anything else?

Check Another of Your Medications Against Adrue

Covers the 2,830 medications we’ve checked against Adrue. Pick one to open its full report.

What to actually watch for

What Pentosan Polysulfate Sodium’s Own FDA Label Lists

This is not an interaction — none of it involves Adrue. These are the most notable effects listed in the ADVERSE REACTIONS section of Pentosan Polysulfate Sodium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

Dehydration Worth acting on
Yellowing of the skin or eyes Worth acting on
Low mood Worth acting on
A low platelet count Worth acting on
Anemia Worth acting on
Shortness of breath Worth acting on
Hives Worth acting on
A low white blood cell count Worth acting on
Bleeding or bruising Worth acting on
An allergic reaction Worth acting on

Showing the 10 most notable of 32 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Pentosan Polysulfate Sodium. Read the label on DailyMed › Where a percentage is shown, it is the share of 6,854 voluntary FDA FAERS reports for Pentosan Polysulfate Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Adrue’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Adrue side to compare — that is a limit of the record, not a statement that Adrue has no side effects.

Everything else you take

See Every Supplement That Interacts With Pentosan Polysulfate Sodium

This page covers Adrue only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pentosan Polysulfate Sodium page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Pentosan Polysulfate Sodium page

“If you take Elmiron (pentosan polysulfate sodium) for bladder pain from interstitial cystitis, this list deserves real attention, starting with one entry. Activated charcoal, the only major-rated interaction of the 17 on file, soaks up medications in the gut and can reduce how much of a dose ever reaches you.”

Reviewed by 2 · Jul 18, 2026

Open the Pentosan Polysulfate Sodium interaction page

One more smart check

Taking Adrue as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Adrue, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Adrue. Even though Adrue itself has no known interaction with Pentosan Polysulfate Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Adrue and Pentosan Polysulfate Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Adrue

Top half

#546 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Pentosan Polysulfate Sodium

Steady interest

#2,258 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Adrue reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Adrue and Pentosan Polysulfate Sodium records this page draws on were last updated June 22, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Adrue

What is Adrue?

Nausea and vomiting
Digestive upset, gas, and diarrhea
Calming or sedative effect
Traditional use for fevers and infections

Adrue (Cyperus articulatus) is a sedge whose rhizome has long been used in traditional medicine for nausea and other stomach complaints, and as a mild calming agent. Solid human studies are lacking, so its real benefits and safe doses are not well established. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Cyperus articulatus · Cyperaceae · Rhizome (underground stem) and tubers; sometimes the essential oil · Dried rhizome, powder, tea or decoction, traditional preparations, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Adrue is a good idea for someone in your situation. Here is what our Adrue record says about it on its own.

Adrue: dosing

There is no established standardized dose for Adrue. Traditional use varies widely, and reliable human studies have not defined a safe and effective amount.If you choose to use a commercial product, follow the directions on the label and do not exceed them. A pharmacist can help you review the product and decide whether it is appropriate for you.Do not use Adrue as a substitute for medical care, especially for ongoing nausea, vomiting, diarrhea, or signs of infection, which may need proper diagnosis and treatment.

From our Adrue monograph — the full record covers uses, side effects and every documented interaction.

Read the full Adrue monograph & all interactions

Medication

About Pentosan Polysulfate

What Is Pentosan Polysulfate Used For?

Brand name: Elmiron

Elmiron (pentosan polysulfate sodium) capsules are indicated for the relief of bladder pain or discomfort associated with interstitial cystitis — a chronic condition that causes bladder pressure, bladder pain, and sometimes pelvic pain.

See full Pentosan Polysulfate drug information

Keep checking

Other Drugs & Adrue

Browse every other medication we’ve checked against Adrue — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

256Moderate

0Minor

2,573No known interaction

256 Moderate 2,573 No interaction

Moderate

256 interactions

Showing 60 of 256 moderate interactions — see all 256 on the Adrue page.

No interaction 2,573 drugs checked — show the list

We also checked Adrue against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,573 medications checked with no known interaction — see the full Adrue list.

See the full Adrue interactions page

See every supplement checked against Pentosan Polysulfate Sodium, ranked by severity

Evidence & sources

Adrue References

The 1 references that drive our Adrue monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Rakotonirina, V. S., Bum, E. N., Rakotonirina, A., and Bopelet, M. Sedative properties of the decoction of the rhizome of Cyperus articulatus. Fitoterapia 2001;72(1):22-29. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Adrue and Pentosan Polysulfate Sodium Together: Common Questions

Is it safe to take Adrue with Pentosan Polysulfate Sodium?

We do not list a known interaction between Adrue and Pentosan Polysulfate Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Adrue and Pentosan Polysulfate Sodium combination checked?

Interactions in our licensed database are recorded against drug classes. Pentosan Polysulfate Sodium is filed under 1 classification, and Adrue has documented interactions with 3 drug classes — none of Pentosan Polysulfate Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Adrue interact with any other medications?

Yes. Adrue has 256 documented drug interactions in our database — Pentosan Polysulfate Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Pentosan Polysulfate Sodium interact with any supplements?

Yes. Pentosan Polysulfate Sodium has documented interactions with 17 supplements in our database — Adrue is not one of them. The Pentosan Polysulfate Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Adrue monograph Uses, safety profile, and every drug interaction in one place Pentosan Polysulfate drug information The full plain-English guide to this medication Pentosan Polysulfate Sodium supplement interactions Every supplement checked against Pentosan Polysulfate Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pentosan Polysulfate Sodium and Adrue?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.