Drug & supplement interaction

Ashitaba + Voclosporin

Voclosporin brand name: Lupkynis.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Ashitaba and Voclosporin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Voclosporin states a food rule worth keeping to.

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Interaction report

Ashitaba and Voclosporin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Voclosporin and Ashitaba in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Ashitaba safety at a glance

Ashitaba overall Use caution Likely safe as a food, but supplement safety has not been well studied.
Pregnancy Avoid Not enough safety data, so avoid concentrated supplements during pregnancy.
Breastfeeding Avoid Not enough safety data, so avoid concentrated supplements while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Voclosporin and Ashitaba? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Voclosporin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Voclosporin is filed under 4 classifications — including qt interval-prolonging drugs, nephrotoxic drugs, cytochrome p450 3a4 (cyp3a4) substrates. Ashitaba has documented interactions with 1 drug class — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Voclosporin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Ashitaba Does Interact With Other Medications

Ashitaba has 186 moderate known drug interactions in our database — Voclosporin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 186 No known interaction 2,644 (incl. Voclosporin)
Taking anything else?

Check Another of Your Medications Against Ashitaba

Covers the 2,830 medications we’ve checked against Ashitaba. Pick one to open its full report.

What to actually watch for

What Voclosporin’s Own FDA Label Lists

This is not an interaction — none of it involves Ashitaba. These are the most notable effects listed in the ADVERSE REACTIONS section of Voclosporin’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 9 of them are worth acting on rather than waiting out — marked below.

  • High potassium Worth acting on
  • Raised blood pressure Worth acting on mentioned in 8.2% of FDA reports for Voclosporin
  • Kidney problems Worth acting on mentioned in 5.4% of FDA reports for Voclosporin
  • An irregular heartbeat Worth acting on
  • Seizures Worth acting on
  • Anemia Worth acting on
  • A severe allergic reaction Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Trouble concentrating

Showing the 10 most notable of 25 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Voclosporin. Read the label on DailyMed › Where a percentage is shown, it is the share of 8,444 voluntary FDA FAERS reports for Voclosporin that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Ashitaba’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Ashitaba side to compare — that is a limit of the record, not a statement that Ashitaba has no side effects.

How to take them

Some Voclosporin Products Have a Food Rule — Ashitaba Should Not Break It

At least one FDA label for a product containing Voclosporin says to take it on an empty stomach. Most supplements — Ashitaba included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Voclosporin on its own and move Ashitaba to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Voclosporin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Administration : LUPKYNIS must be swallowed whole on an empty stomach.

From the Dosage and Administration section of the FDA label we read for Voclosporin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Voclosporin

This page covers Ashitaba only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voclosporin page lists 152 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Asarabacca (major) and Cesium (major).

By severity: 10 major · 101 moderate · 41 minor.

Open the Voclosporin interaction page

One more smart check

Taking Ashitaba as Part of a Dietary Supplement Product? Check It for Interactions

We hold 41 real supplement products containing Ashitaba, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ashitaba. Even though Ashitaba itself has no known interaction with Voclosporin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ashitaba and Voclosporin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ashitaba
Top half

#629 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Voclosporin
Top half

#728 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Ashitaba reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Ashitaba and Voclosporin records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Ashitaba

What is Ashitaba?

Ashitaba
  • General wellness and longevity
  • Antioxidant support
  • Heart and cholesterol health
  • Digestive and stomach support
  • Anti-inflammatory

Ashitaba is a leafy plant from Japan that is eaten as a vegetable and taken as a supplement for general health, antioxidant, and heart benefits. Most of the supporting research comes from laboratory and animal studies, so its real benefits in people are still uncertain. It appears generally well tolerated as a food, but talk to your pharmacist or doctor before using concentrated supplements.

Angelica keiskei · Apiaceae · Leaves, stems, and roots · Tea, capsules, powder, dried leaves, fresh vegetable, juice

An interaction check asks whether these two react with each other — it does not ask whether Ashitaba is a good idea for someone in your situation. Here is what our Ashitaba record says about it on its own.

Ashitaba: dosing

There is no well-established, standardized dose for Ashitaba supplements. Studies have used different forms and amounts, so a single "correct" dose has not been set.If you choose to use an Ashitaba product, follow the directions on the label and do not exceed the recommended amount.

From our Ashitaba monograph — the full record covers uses, side effects and every documented interaction.

Read the full Ashitaba monograph & all interactions
Medication

About Voclosporin

What Is Voclosporin Used For?

Brand name: Lupkynis

Lupkynis (voclosporin) is approved to treat active lupus nephritis (LN) — a serious kidney inflammation caused by lupus — in adults. It is always used alongside a background immunosuppressive therapy regimen, specifically with mycophenolate mofetil (MMF) and corticosteroids.

Lupkynis is not recommended for use in combination with cyclophosphamide, as safety and efficacy in that combination have not been established.

See full Voclosporin drug information
Keep checking

Other Drugs & Ashitaba

Browse every other medication we’ve checked against Ashitaba — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
186Moderate
0Minor
2,643No known interaction
186 Moderate 2,643 No interaction
Moderate

186 interactions

Showing 60 of 186 moderate interactions — see all 186 on the Ashitaba page.

No interaction 2,643 drugs checked — show the list

We also checked Ashitaba against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,643 medications checked with no known interaction — see the full Ashitaba list.

See the full Ashitaba interactions page
See every supplement checked against Voclosporin, ranked by severity
Evidence & sources

Ashitaba References

The 2 references that drive our Ashitaba monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kwon D, Yoon S, Carter O, Bailey GS, Dashwood RH. Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells. Biofactors. 2006;26(4):231
  2. Noh HM, Ahn EM, Yun JM, Cho BL, Paek YJ. Angelica keiskei Koidzumi extracts improve some markers of liver function in habitual alcohol drinkers: a randomized double-blind clinical trial. J Med Food. 2015;18(2):166-72.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Ashitaba and Voclosporin Together: Common Questions

Is it safe to take Ashitaba with Voclosporin?
We do not list a known interaction between Ashitaba and Voclosporin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Ashitaba and Voclosporin at the same time of day?
At least one FDA label for a product containing Voclosporin says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Voclosporin on its own and move Ashitaba to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Ashitaba and Voclosporin combination checked?
Interactions in our licensed database are recorded against drug classes. Voclosporin is filed under 4 classifications, and Ashitaba has documented interactions with 1 drug class — none of Voclosporin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Ashitaba interact with any other medications?
Yes. Ashitaba has 186 documented drug interactions in our database — Voclosporin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Voclosporin interact with any supplements?
Yes. Voclosporin has documented interactions with 152 supplements in our database — Ashitaba is not one of them. The Voclosporin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Ashitaba monograph Uses, safety profile, and every drug interaction in one place Voclosporin drug information The full plain-English guide to this medication Voclosporin supplement interactions Every supplement checked against Voclosporin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Voclosporin and Ashitaba?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.