Drug & supplement interaction

Beer + Erythromycin, Sulfisoxazole

Erythromycin, Sulfisoxazole brand name: Eryzole.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Erythromycin, Sulfisoxazole falls into 3 drug categories that Beer can interact with; the most serious is rated major. Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction report
SeverityMajor
LikelihoodProbable
Interactions3
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Beer and Erythromycin, Sulfisoxazole

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Beer interacts with whole categories of medication. Erythromycin, Sulfisoxazole falls into 3 of those categories, so it can interact with Beer in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Major).

Major

HEPATOTOXIC DRUGS

1 of 3

Why this applies to Erythromycin, Sulfisoxazole

Erythromycin, Sulfisoxazole falls under HEPATOTOXIC DRUGS — the group Beer interacts with.

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.
Concomitant use of excessive amounts of alcohol with potentially hepatotoxic drugs can increase the risk of liver damage.
Severity Major Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: both pieces of Eryzole (the erythromycin and the sulfa portion, sulfisoxazole) can be hard on your liver, and so can alcohol. When you add beer on top of this combo antibiotic, you're asking your liver to handle two stressors at once, which can raise the chance of liver irritation or, in rarer cases, real liver injury.

What might that look like? Things like nausea, belly pain on the upper right side, unusual tiredness, dark urine, or a yellow tint to your skin or eyes. An occasional drink is unlikely to be a big deal for most people, but regular or heavy drinking is where the worry climbs. Since this antibiotic course is usually short, the easiest move is to skip beer until you finish it. Please check with your pharmacist or doctor about your situation.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
  2. Thummel, K. E., Slattery, J. T., Ro, H., Chien, J. Y., Nelson, S. D., Lown, K. E., and Watkins, P. B. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin Pharmacol Ther 2000;67(6):591-599. PubMed
Major

ERYTHROMYCIN

2 of 3
Concomitant use may increase blood alcohol levels and adverse effects.
Concomitant use of erythromycin with alcohol can increase blood alcohol levels and adverse effects.
Severity Major Likelihood Probable Evidence C

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Eryzole, which combines erythromycin and sulfisoxazole. The erythromycin part can actually slow how fast your stomach empties and may speed alcohol into your bloodstream, so a beer can hit you harder and your blood alcohol can climb higher than usual. That means more drowsiness, dizziness, nausea, and impaired coordination than you'd expect from the same drink on its own.

On top of that, alcohol and this antibiotic can each upset your stomach, so combining them may worsen nausea or stomach pain while you're trying to fight an infection. This is a recognized, fairly likely interaction, so my honest advice is to skip the beer while you're on this medicine. If you have questions about your situation, please check with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed
Moderate

SULFONAMIDE ANTIBIOTICS

3 of 3

Erythromycin, Sulfisoxazole also falls under SULFONAMIDE ANTIBIOTICS.

Concomitant use may cause a disulfiram-like reaction.
Sulfonamide antibiotics can cause a disulfiram-like reaction when taken with alcohol.
Severity Moderate Likelihood Possible Evidence C

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This medication is a combo product, and the part that matters here is the sulfisoxazole, which is a sulfa antibiotic. Some sulfa drugs can react with the alcohol in beer and trigger what we call a disulfiram-like reaction. That can mean flushing, a pounding heartbeat, headache, nausea, vomiting, and feeling lightheaded or generally lousy. It is uncomfortable, though usually not dangerous.

To be honest, the evidence for this with sulfa antibiotics is on the weaker, consensus-based side, so it does not happen to everyone. Still, why risk feeling sick while you are already fighting an infection? The simplest move is to skip beer and other alcohol until you finish the course. If you are unsure, a quick chat with your pharmacist or doctor will set you straight.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fraser AG. Pharmacokinetic interactions between alcohol and other drugs. Clin Pharmacokinet 1997;33:79-90. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Beer Also Interacts With Other Medications

Beer has 653 major, 272 moderate known drug interactions in our database — the Erythromycin, Sulfisoxazole one above is among them. If you take anything else, check it against the full list below.

Major 653 Moderate 272 No known interaction 1,905 (incl. Erythromycin, Sulfisoxazole)
Taking anything else?

Check Another of Your Medications Against Beer

Covers the 2,830 medications we’ve checked against Beer. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Erythromycin, Sulfisoxazole

This page covers Beer only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Erythromycin, Sulfisoxazole page lists 248 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 13 major · 196 moderate · 39 minor.

From our pharmacist’s overview on the Erythromycin, Sulfisoxazole page

“Eryzole combines two antibiotics, erythromycin and sulfisoxazole, and its supplement list calls for genuine care, especially the small set of major-rated pairings. Erythromycin interferes with a liver enzyme called CYP3A4, and nearly half of the flagged ingredients travel that same pathway, so levels can swing in ways that matter.”

Reviewed by 2 · Jul 18, 2026

Open the Erythromycin, Sulfisoxazole interaction page

How much people look this up

Where Beer and Erythromycin, Sulfisoxazole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beer
Top 25%

#322 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Erythromycin, Sulfisoxazole
Steady interest

#2,691 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Beer

What is Beer?

Beer
  • Social and recreational drinking
  • Relaxation
  • Heart health (popular belief)
  • Bone health (popular belief)
  • Source of antioxidants and B vitamins

Beer is an alcoholic beverage that contains some minerals, B vitamins, and plant compounds from hops and grain, but it is not a health supplement. Any possible benefits come only from light-to-moderate intake, and they are easily outweighed by the well-known harms of alcohol. The safest amount of alcohol for health is none, and beer should be avoided in pregnancy and breastfeeding.

Read the full Beer monograph & all interactions
Keep checking

Other Drugs & Beer

Browse every other medication we’ve checked against Beer — both the ones with a known interaction and the ones without. Select any drug for the full detail.

653Major
272Moderate
0Minor
1,904No known interaction
653 Major 272 Moderate 1,904 No interaction
Major

653 interactions

Showing 60 of 653 major interactions — see all 653 on the Beer page.

Moderate

272 interactions

Showing 60 of 272 moderate interactions — see all 272 on the Beer page.

No interaction 1,904 drugs checked — show the list

We also checked Beer against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,904 medications checked with no known interaction — see the full Beer list.

See the full Beer interactions page
See every supplement checked against Erythromycin, Sulfisoxazole, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Beer monograph › Uses, safety, and every drug interaction in one place Erythromycin, Sulfisoxazole supplement interactions › Every supplement checked against Erythromycin, Sulfisoxazole, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Beer and Erythromycin, Sulfisoxazole Together: Common Questions

Can you take Beer with Erythromycin, Sulfisoxazole?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Beer and Erythromycin, Sulfisoxazole?
Erythromycin, Sulfisoxazole belongs to more than one drug category, and Beer interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Beer and Erythromycin, Sulfisoxazole interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.