Medication interaction hub

What Supplements Interact with Erythromycin, Sulfisoxazole?

Erythromycin, Sulfisoxazole brand name: Eryzole. Every interaction below applies to the brands too.

248 Interactions 13 Major 196 Moderate 39 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Erythromycin, Sulfisoxazole? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Erythromycin, Sulfisoxazole against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Eryzole combines two antibiotics, erythromycin and sulfisoxazole, and its supplement list calls for genuine care, especially the small set of major-rated pairings. Erythromycin interferes with a liver enzyme called CYP3A4, and nearly half of the flagged ingredients travel that same pathway, so levels can swing in ways that matter. Grapefruit juice can drive drug levels up, St. John's wort can drag them down, and PABA may blunt the sulfa component's ability to fight bacteria.

Other clusters put added stress on the liver, alcohol included, or can stretch the QT interval, the electrical pause between heartbeats. On the gentler end, everyday probiotics appear here simply because the antibiotic can kill their live organisms, so space those well apart from doses. For scale, the list runs to 248 ingredients, 39 minor and 196 moderate, but the 13 rated major deserve your attention ahead of everything else.

— , Clinical Pharmacist · July 18, 2026

Major 13 Moderate 196 Minor 39 No known interaction 1,204

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Erythromycin, Sulfisoxazole: Top Interactions at a Glance

The most significant Erythromycin, Sulfisoxazole supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 248 interacting ingredients — plus 1,204 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Erythromycin, Sulfisoxazole + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Grapefruit + Erythromycin, Sulfisoxazolei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction Major Likelihood Likely Para-aminobenzoic Acid (paba) + Erythromycin, Sulfisoxazolei

Theoretically, concomitant use of PABA and sulfonamide antibiotics inhibits the antibacterial effects of sulfonamide.

Read the full interaction Major Likelihood Likely Siberian Cocklebur + Erythromycin, Sulfisoxazolei

Siberian cocklebur can adversely affect the liver.

Read the full interaction Major Likelihood Probable Activated Charcoal + Erythromycin, Sulfisoxazolei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Arsenic + Erythromycin, Sulfisoxazolei

Arsenic trioxide can prolong the QT interval.

Read the full interaction Major Likelihood Probable Beer + Erythromycin, Sulfisoxazolei

Concomitant use of alcohol with hepatotoxic drugs may increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Erythromycin, Sulfisoxazole

All 1,452 ingredients in our database, ranked by severity — 248 with a Erythromycin, Sulfisoxazole interaction on file and 1,204 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Erythromycin, Sulfisoxazole?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Schizonepeta with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that schizonepetin, a monoterpene constituent of schizonepeta, induces cytochrome P450 (CYP) 3A4.

Full Schizonepeta + Erythromycin, Sulfisoxazole answer

Can you take Feverfew with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.

Full Feverfew + Erythromycin, Sulfisoxazole answer

Can you take Propolis with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.

Full Propolis + Erythromycin, Sulfisoxazole answer

Can you take Bulbine Natalensis with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Bulbine natalensis stem might reduce the levels and clinical effects of CYP3A4 substrates.

Full Bulbine Natalensis + Erythromycin, Sulfisoxazole answer

Can you take Calamus with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking calamus with drugs metabolized by CYP3A4 might increase drug levels and potentially increase the risk of adverse effec...

Full Calamus + Erythromycin, Sulfisoxazole answer

Can you take Camphor with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Erythromycin, Sulfisoxazole answer

Can you take Cannabinol (cbn) with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and clinical effects of cannabinol.

Full Cannabinol (cbn) + Erythromycin, Sulfisoxazole answer

Can you take Cannabis with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP3A4 inhibitors might increase the levels and adverse effects of cannabis.

Full Cannabis + Erythromycin, Sulfisoxazole answer

Can you take Cassia Cinnamon with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Erythromycin, Sulfisoxazole answer

Can you take Cat's Claw with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cat's claw might increase or decrease the levels and effects of drugs metabolized by CYP3A4.

Full Cat's Claw + Erythromycin, Sulfisoxazole answer

Can you take Ceylon Leadwort with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Plumbagin, a constituent of Ceylon leadwort, has been shown to inhibit cytochrome P450 3A4 (CYP3A4) in vitro.

Full Ceylon Leadwort + Erythromycin, Sulfisoxazole answer

Can you take Chanca Piedra with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.

Full Chanca Piedra + Erythromycin, Sulfisoxazole answer

Can you take Chaparral with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Erythromycin, Sulfisoxazole answer

Can you take Chlorella with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chlorella might have additive effects with photosensitizing drugs.

Full Chlorella + Erythromycin, Sulfisoxazole answer

Can you take Chokeberry with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase levels of drugs metabolized by CYP3A4.

Full Chokeberry + Erythromycin, Sulfisoxazole answer

Can you take Cilantro with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from in vitro research suggests that coriandrin, a constituent of cilantro, has photosensitizing effects.

Full Cilantro + Erythromycin, Sulfisoxazole answer

Can you take Cinchona with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cinchona with other QT interval-prolonging drugs might cause an additive effect and increase the risk of ventricular a...

Full Cinchona + Erythromycin, Sulfisoxazole answer

Can you take Clove with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.

Full Clove + Erythromycin, Sulfisoxazole answer

Can you take Cocoa with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the levels and adverse effects of caffeine.

Full Cocoa + Erythromycin, Sulfisoxazole answer

Can you take Cola Nut with Erythromycin, Sulfisoxazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, CYP1A2 inhibitors might increase the levels and adverse effects of the caffeine in cola nut.

Full Cola Nut + Erythromycin, Sulfisoxazole answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Erythromycin, Sulfisoxazole is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Erythromycin, Sulfisoxazole, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Erythromycin, Sulfisoxazole sits in 13 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Qt Interval-Prolonging Drugs 13 ingredients

Medications that can affect the heart's electrical rhythm (the QT interval). Supplements with similar effects can add to that risk.

13 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Macrolide Antibiotics 11 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

11 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Cytochrome P450 2C9 (Cyp2C9) Inhibitors 4 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

4 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Sulfonamide Antibiotics 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Erythromycin 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Erythromycin, Sulfisoxazole through this category.

Related: does Erythromycin, Sulfisoxazole deplete any nutrients?

Erythromycin, Sulfisoxazole has 7 reported nutrient associations in the research literature — see the Erythromycin, Sulfisoxazole nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Erythromycin, Sulfisoxazole

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Erythromycin, Sulfisoxazole.

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Pharmacist Counseling Corner

Erythromycin, Sulfisoxazole & Supplements: Common Questions

What supplements interact with Erythromycin, Sulfisoxazole?
Our database currently documents 248 ingredients with a known Erythromycin, Sulfisoxazole interaction (13 major, 196 moderate, 39 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 248. The highest-ranked right now: Grapefruit, Para-aminobenzoic Acid (paba), Siberian Cocklebur.
Which Erythromycin, Sulfisoxazole supplement interactions are the most serious?
The 13 major-rated combinations — led by Grapefruit, Para-aminobenzoic Acid (paba), Siberian Cocklebur, Activated Charcoal and Arsenic — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Erythromycin, Sulfisoxazole?
Plenty of supplements coexist fine with Erythromycin, Sulfisoxazole; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Eryzole have the same supplement interactions as Erythromycin, Sulfisoxazole?
Yes — Eryzole all contain Erythromycin, Sulfisoxazole, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Erythromycin, Sulfisoxazole deplete any vitamins or nutrients?
It might — Erythromycin, Sulfisoxazole has 7 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Erythromycin, Sulfisoxazole nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Erythromycin, Sulfisoxazole and my other medications?
This page covers Erythromycin, Sulfisoxazole against supplements and herbal ingredients. Checking Erythromycin, Sulfisoxazole against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.