Drug & supplement interaction

Beet + Tolnaftate

Tolnaftate brand name: Tinactin.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Beet and Tolnaftate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Beet and Tolnaftate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tolnaftate and Beet in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Beet safety at a glance

Beet overall Generally safe Beet is widely eaten as a food and is generally well tolerated for most adults.
Pregnancy Use caution Beet as a food is fine, but concentrated supplements lack safety data, so use caution.
Breastfeeding Use caution Beet as a food is fine, but there is not enough data on concentrated supplements.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tolnaftate and Beet? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tolnaftate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tolnaftate is filed under 2 classifications — antifungals, oral drugs. Beet has documented interactions with 3 drug classes — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate), antihypertensive drugs (minor) and cytochrome p450 1a2 (cyp1a2) substrates (minor) — and none of Tolnaftate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Beet Does Interact With Other Medications

Beet has 643 moderate, 218 minor known drug interactions in our database — Tolnaftate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 643 Minor 218 No known interaction 1,969 (incl. Tolnaftate)
Taking anything else?

Check Another of Your Medications Against Beet

Covers the 2,830 medications we’ve checked against Beet. Pick one to open its full report.

What to actually watch for

What Beet Itself Has Been Linked To

This is not an interaction — nothing below involves Tolnaftate. It is the side-effect record for Beet on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Beet, this list is the first place to look. 2 entries are worth acting on rather than waiting out — marked below.

  • Bleeding in the gut / Anemia Worth acting on Additional detail

    “Orally, beet juice may cause red stools. This red coloring of the stools is not harmful. Additionally, beet supplementation has been reported to cause black stools. In one case, a 79-year-old male on apixaban and clopidogrel presented with black stools, nausea, and vomiting after taking beet pills 2-3 days prior.”

    Beet · Natural Medicines adverse-effect record, reported in anemia.

    6 sources cited
    1. 94470. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
    2. 97726. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
    3. 100142. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
    4. 100145. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
    5. 105762. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
    6. 113426. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed
  • Kidney problems Worth acting on Additional detail

    “Orally, beet seems to be well tolerated when used for medicinal purposes, short term.

    Most Common Adverse Effects:

    Orally: Red stools and red urine.

    Serious Adverse Effects (Rare):

    Orally: Hypocalcemia and kidney damage when ingested in large amounts.”

    Beet · Natural Medicines adverse-effect record, reported in hypocalcemia.

  • Constipation / Diarrhea / Vomiting / Nausea Additional detail

    Recorded for Beet in the same Natural Medicines adverse-effect record shown under Bleeding in the gut / Anemia above.

Everything above comes from the Natural Medicines adverse-effect record for Beet — expand a row for the licensed statement it rests on. We haven’t matched Tolnaftate to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Tolnaftate.

From our Q&A

Questions About Beet or Tolnaftate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Beet or Tolnaftate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Tolnaftate

This page covers Beet only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolnaftate page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 12 minor.

From our pharmacist’s overview on the Tolnaftate page

“For anyone using tolnaftate (Tinactin), the antifungal in athlete's foot creams and sprays, activated charcoal is the interaction to understand before all others. It holds the only major rating among the 20 ingredients on file, since charcoal binds many medicines and can lower how much reaches the body, even drugs not given by mouth.”

Reviewed by 2 · Jul 18, 2026

Open the Tolnaftate interaction page

One more smart check

Taking Beet as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4,785 real supplement products containing Beet, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Beet. Even though Beet itself has no known interaction with Tolnaftate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Beet and Tolnaftate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Beet
Top 5%

#39 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolnaftate
Steady interest

#1,418 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Beet reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Beet and Tolnaftate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Beet

What is Beet?

Beet
  • High blood pressure
  • Exercise and athletic performance
  • Heart and circulation support
  • General antioxidant/anti-inflammatory support
  • Liver and digestive support

Beet, especially beetroot juice, is a nitrate-rich food that may modestly lower blood pressure and slightly improve exercise performance in some people. It is generally safe as a food, but supplement effects are modest and not a substitute for prescribed treatment, so talk with your pharmacist or doctor before relying on it.

Beta vulgaris · Amaranthaceae · Root and leaves (greens) · Juice, powder, capsules, tablets, whole food, concentrated shots, gels

An interaction check asks whether these two react with each other — it does not ask whether Beet is a good idea for someone in your situation. Here is what our Beet record says about it on its own.

Beet: dosing

There is no official standardized dose of beet for supplement use. Studies have used a range of amounts of beetroot juice or powder, often based on nitrate content, but the best dose is not firmly established.If you choose a beet supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Beet monograph — the full record covers uses, side effects and every documented interaction.

Read the full Beet monograph & all interactions
Medication

About Tolnaftate

What Is Tolnaftate Used For?

Brand name: Tinactin

Tolnaftate treats common fungal skin infections — specifically athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). It also helps relieve the itching, cracking, burning, scaling, redness, and soreness that come with these infections.

Several products also help prevent athlete's foot from coming back with regular daily use. Note that tolnaftate is not effective on the scalp or nails — though some patch products are applied around the nail and cuticle area to address skin surrounding the nail.

Most-Reported Side Effects for Tolnaftate

From FAERS, the FDA’s public side-effect reporting system (1,403 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 88 reports
Nausea 86 reports
Dyspnea 80 reports
Diarrhea 73 reports
Anxiety 69 reports
See full Tolnaftate drug information
Keep checking

Other Drugs & Beet

Browse every other medication we’ve checked against Beet — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
643Moderate
218Minor
1,968No known interaction
643 Moderate 218 Minor 1,968 No interaction
Moderate

643 interactions

Showing 60 of 643 moderate interactions — see all 643 on the Beet page.

Minor

218 interactions

Showing 60 of 218 minor interactions — see all 218 on the Beet page.

No interaction 1,968 drugs checked — show the list

We also checked Beet against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,968 medications checked with no known interaction — see the full Beet list.

See the full Beet interactions page
See every supplement checked against Tolnaftate, ranked by severity
Evidence & sources

Beet References

The 14 references that drive our Beet monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Beet and Tolnaftate Together: Common Questions

Is it safe to take Beet with Tolnaftate?
We do not list a known interaction between Beet and Tolnaftate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Beet and Tolnaftate combination checked?
Interactions in our licensed database are recorded against drug classes. Tolnaftate is filed under 2 classifications, and Beet has documented interactions with 3 drug classes — none of Tolnaftate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Beet interact with any other medications?
Yes. Beet has 861 documented drug interactions in our database — Tolnaftate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tolnaftate interact with any supplements?
Yes. Tolnaftate has documented interactions with 20 supplements in our database — Beet is not one of them. The Tolnaftate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Beet monograph Uses, safety profile, and every drug interaction in one place Tolnaftate drug information The full plain-English guide to this medication Tolnaftate supplement interactions Every supplement checked against Tolnaftate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tolnaftate and Beet?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.