Drug & supplement interaction

Black Hoof Mushroom + Ramelteon

Ramelteon brand name: Rozerem.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Black Hoof Mushroom has a moderate interaction with Ramelteon. Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Black Hoof Mushroom and Ramelteon

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

Why this applies to Ramelteon

Ramelteon falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Black Hoof Mushroom interacts with.

Theoretically, black hoof mushroom might increase the levels and clinical effects of CYP1A2 substrates.
In vitro, polysaccharides from black hoof mushroom grown in culture inhibit CYP1A2. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for Ramelteon: your body clears it mainly through a liver enzyme called CYP1A2. In lab dish studies, compounds from Black Hoof Mushroom seemed to slow that same enzyme down. If that were to happen in real life, more Ramelteon could hang around in your system, which might leave you feeling extra drowsy, groggy, or dizzy the next morning, or make it harder to wake up fully.

I'll be straight with you, though: this concern comes only from test-tube research, not from people, so it's theoretical at this point. Ramelteon isn't a prodrug, so the direction would be stronger effects, not weaker. Still, before you pair these two, give your pharmacist or doctor a quick heads-up so they can keep an eye on you.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Shon, Y. H. and Nam, K. S. Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus. Biotechnol Lett 2003;25(2):167-172. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Black Hoof Mushroom Also Interacts With Other Medications

Black Hoof Mushroom has 307 moderate known drug interactions in our database — the Ramelteon one above is one of them. If you take anything else, check it against the full list below.

Moderate 307 No known interaction 2,523 (incl. Ramelteon)
Taking anything else?

Check Another of Your Medications Against Black Hoof Mushroom

Covers the 2,830 medications we’ve checked against Black Hoof Mushroom. Pick one to open its full report.

From our Q&A

Questions About Black Hoof Mushroom or Ramelteon

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Black Hoof Mushroom or Ramelteon, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ramelteon

This page covers Black Hoof Mushroom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ramelteon page lists 228 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 173 moderate · 46 minor.

From our pharmacist’s overview on the Ramelteon page

“Ramelteon (Rozerem) is a prescription sleep aid, and its 228 interacting supplements call for real care, starting with the nine rated major. The frustrating part is that the things sleepless people typically reach for, kava, CBD, a glass of wine before bed, sit at the heart of the problem.”

Reviewed by 2 · Jul 18, 2026

Open the Ramelteon interaction page

How much people look this up

Where Black Hoof Mushroom and Ramelteon Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Hoof Mushroom
Steady interest

#1,226 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ramelteon
Top half

#1,053 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Black Hoof Mushroom

What is Black Hoof Mushroom?

Black Hoof Mushroom
  • Immune system support
  • Antioxidant support
  • General wellness
  • Traditional cancer-supportive use
  • Inflammation

Black Hoof Mushroom (Phellinus linteus) is a medicinal mushroom long used in East Asian traditional medicine, mainly for immune support. Most of the supporting evidence comes from laboratory and animal studies, and high-quality human research is limited. Talk to your pharmacist or doctor before using it, especially if you have a health condition or take other medicines.

Read the full Black Hoof Mushroom monograph & all interactions
Medication

About Ramelteon

What Is Ramelteon Used For?

Brand name: Rozerem

Ramelteon treats insomnia marked by difficulty with sleep onset, meaning trouble falling asleep.

This use is supported for Rozerem and for ramelteon tablets (including film-coated tablets). The studies behind it lasted up to six months.

See full Ramelteon drug information
Keep checking

Other Drugs & Black Hoof Mushroom

Browse every other medication we’ve checked against Black Hoof Mushroom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
307Moderate
0Minor
2,522No known interaction
307 Moderate 2,522 No interaction
Moderate

307 interactions

Showing 60 of 307 moderate interactions — see all 307 on the Black Hoof Mushroom page.

No interaction 2,522 drugs checked — show the list

We also checked Black Hoof Mushroom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,522 medications checked with no known interaction — see the full Black Hoof Mushroom list.

See the full Black Hoof Mushroom interactions page
See every supplement checked against Ramelteon, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Black Hoof Mushroom monograph › Uses, safety, and every drug interaction in one place Ramelteon supplement interactions › Every supplement checked against Ramelteon, ranked by severity Ramelteon drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Black Hoof Mushroom and Ramelteon Together: Common Questions

Can you take Black Hoof Mushroom with Ramelteon?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Black Hoof Mushroom and Ramelteon interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ramelteon and Black Hoof Mushroom?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.