Drug & supplement interaction

Blessed Thistle + Sarilumab

Sarilumab brand name: Kevzara.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Blessed Thistle and Sarilumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Blessed Thistle and Sarilumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sarilumab and Blessed Thistle in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Blessed Thistle safety at a glance

Blessed Thistle overall Use caution Often well tolerated in small amounts, but human safety data are limited and large doses can cause nausea or vomiting.
Pregnancy Likely Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Use caution Used traditionally to support milk supply, but safety has not been well studied, so check with your doctor first.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sarilumab and Blessed Thistle? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sarilumab

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sarilumab is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) inducers, immunosuppressants. Blessed Thistle has documented interactions with 3 drug classes — the most serious being antacids (minor), h2-blockers (minor) and proton pump inhibitors (ppis) (minor) — and none of Sarilumab’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Blessed Thistle Does Interact With Other Medications

Blessed Thistle has 36 minor known drug interactions in our database — Sarilumab isn’t one of them. If you take anything else, check it against the full list below.

Minor 36 No known interaction 2,794 (incl. Sarilumab)
Taking anything else?

Check Another of Your Medications Against Blessed Thistle

Covers the 2,830 medications we’ve checked against Blessed Thistle. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Blessed Thistle and Sarilumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Blessed Thistle

    “Topically, blessed thistle can cause an allergic reaction, such as dermatitis, in individuals sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many other herbs (12).”

    Blessed Thistle · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Sarilumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Sarilumab. Read the label on DailyMed ›

  • A skin rash reported in 13.3% of FDA reports for Sarilumab Additional detail

    Blessed Thistle

    Recorded for Blessed Thistle in the same Natural Medicines adverse-effect record shown under An allergic reaction above.

    Sarilumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Sarilumab, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Blessed Thistle but not commonly for Sarilumab: stomach upset and vomiting.

Effects for Sarilumab come from the ADVERSE REACTIONS section of its FDA label; effects for Blessed Thistle come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 24,738 voluntary FDA FAERS reports for Sarilumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Blessed Thistle in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Sarilumab

This page covers Blessed Thistle only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sarilumab page lists 72 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Active Hexose Correlated Compound (ahcc) (moderate), Alfalfa (moderate), Alkanna (moderate), Alpine Ragwort (moderate) and American Ginseng (moderate).

By severity: 71 moderate · 1 minor.

From our pharmacist’s overview on the Sarilumab page

“Sarilumab (Kevzara) works by quieting an overactive immune system in rheumatoid arthritis, and most of the supplements on this page push the other way. Immune stimulants such as ashwagandha, astragalus, and American ginseng could in theory blunt the drug's benefit and let joint symptoms creep back.”

Reviewed by 2 · Jul 18, 2026

Open the Sarilumab interaction page

One more smart check

Taking Blessed Thistle as Part of a Dietary Supplement Product? Check It for Interactions

We hold 729 real supplement products containing Blessed Thistle, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Blessed Thistle. Even though Blessed Thistle itself has no known interaction with Sarilumab, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Blessed Thistle and Sarilumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Blessed Thistle
Top 25%

#325 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sarilumab
Steady interest

#2,181 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Blessed Thistle reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Blessed Thistle and Sarilumab records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Blessed Thistle

What is Blessed Thistle?

Blessed Thistle
  • Digestive upset and poor appetite
  • Boosting bile flow
  • General bitter tonic
  • Supporting milk supply during breastfeeding (traditional)
  • Wound care (traditional, topical)

Blessed thistle is a bitter herb traditionally used to stimulate appetite and ease mild digestive complaints. High-quality human studies are lacking, so its benefits are not well proven. It is likely fine for short-term use in small, food-like amounts, but it should be avoided in pregnancy and used with caution by people allergic to ragweed and related plants.

Cnicus benedictus · Asteraceae · Aerial parts (leaves, stems, and flowers) · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Blessed Thistle is a good idea for someone in your situation. Here is what our Blessed Thistle record says about it on its own.

Blessed Thistle: dosing

There is no official, standardized dose of blessed thistle. The right amount can vary depending on the product and the form (tea, tincture, or capsules).The best approach is to follow the directions on the product label and not exceed the recommended amount, since large doses are more likely to cause nausea and vomiting.

From our Blessed Thistle monograph — the full record covers uses, side effects and every documented interaction.

Read the full Blessed Thistle monograph & all interactions
Medication

About Sarilumab Injection

What Is Sarilumab Injection Used For?

Brand name: Kevzara

Kevzara (sarilumab) injection is approved for three conditions. In adults, it treats moderately to severely active rheumatoid arthritis (RA) when at least one other disease-modifying drug hasn't worked well enough or caused intolerance. It also treats polymyalgia rheumatica (PMR) in adults who haven't responded adequately to corticosteroids or who can't tolerate tapering them.

Kevzara is also approved for polyarticular juvenile idiopathic arthritis (pJIA) — a form of childhood arthritis — but only in patients who weigh 63 kg (about 139 lbs) or more. It is not approved for pediatric patients below that weight due to the lack of an appropriate dosage form.

Most-Reported Side Effects for Sarilumab

From FAERS, the FDA’s public side-effect reporting system (26,260 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Arthralgia 5,168 reports
Rheumatoid arthritis 4,646 reports
Joint swelling 4,578 reports
Fatigue 3,555 reports
Rash 3,349 reports
See full Sarilumab Injection drug information
Keep checking

Other Drugs & Blessed Thistle

Browse every other medication we’ve checked against Blessed Thistle — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
36Minor
2,793No known interaction
36 Minor 2,793 No interaction
Minor

36 interactions

No interaction 2,793 drugs checked — show the list

We also checked Blessed Thistle against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,793 medications checked with no known interaction — see the full Blessed Thistle list.

See the full Blessed Thistle interactions page
See every supplement checked against Sarilumab, ranked by severity
Evidence & sources

Blessed Thistle References

The 2 references that drive our Blessed Thistle monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Blessed Thistle and Sarilumab Together: Common Questions

Is it safe to take Blessed Thistle with Sarilumab?
We do not list a known interaction between Blessed Thistle and Sarilumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Blessed Thistle and Sarilumab have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Blessed Thistle and Sarilumab combination checked?
Interactions in our licensed database are recorded against drug classes. Sarilumab is filed under 2 classifications, and Blessed Thistle has documented interactions with 3 drug classes — none of Sarilumab's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Blessed Thistle interact with any other medications?
Yes. Blessed Thistle has 36 documented drug interactions in our database — Sarilumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sarilumab interact with any supplements?
Yes. Sarilumab has documented interactions with 72 supplements in our database — Blessed Thistle is not one of them. The Sarilumab interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Blessed Thistle monograph Uses, safety profile, and every drug interaction in one place Sarilumab Injection drug information The full plain-English guide to this medication Sarilumab supplement interactions Every supplement checked against Sarilumab, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sarilumab and Blessed Thistle?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.