Drug & supplement interaction

Boneset + Dicloxacillin Sodium

Dicloxacillin Sodium brand names: Dynapen, Pathocil, Dycill, Pathocil Injection.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Boneset and Dicloxacillin Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Dicloxacillin Sodium states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Boneset and Dicloxacillin Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Dicloxacillin Sodium and Boneset in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Boneset safety at a glance

Boneset overall Use caution Limited safety data and possible liver-toxic alkaloids mean it should be used carefully and short-term, if at all.
Pregnancy Possibly Unsafe When used orally. Hepatotoxic PAs are common in this genus of plants; however, the alkaloids in boneset have not been adequately characterized to determine thei... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Hepatotoxic PAs are common in this genus of plants; however, the alkaloids in boneset have not been adequately characterized to determine thei... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Dicloxacillin Sodium and Boneset? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Dicloxacillin Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Dicloxacillin Sodium is filed under 5 classifications — including penicillin, antibiotic drugs, nephrotoxic drugs. Boneset has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Dicloxacillin Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Boneset Does Interact With Other Medications

Boneset has 87 moderate known drug interactions in our database — Dicloxacillin Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 87 No known interaction 2,743 (incl. Dicloxacillin Sodium)
Taking anything else?

Check Another of Your Medications Against Boneset

Covers the 2,830 medications we’ve checked against Boneset. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Boneset and Dicloxacillin Sodium May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Boneset

    “Orally, boneset is reported to cause nausea and severe diarrhea and vomiting. Additionally, other plants in the Eupatorium genus contain the hepatotoxic pyrrolizidine alkaloids (PAs). However, the alkaloids in boneset have not been adequately characterized to determine their toxic potential. Liver toxicity and liver damage may be possible in high doses.”

    Boneset · Natural Medicines adverse-effect record, reported in diarrhea.

    2 sources cited
    1. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    2. 102557. Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.

    Dicloxacillin Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Dicloxacillin Sodium. Read the label on DailyMed ›

  • Diarrhea / Vomiting / Nausea reported in 7.7% of FDA reports for Dicloxacillin Sodium Additional detail

    Boneset

    “Orally, boneset has been reported to cause nausea and severe diarrhea and vomiting.”

    Boneset · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

    Dicloxacillin Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Dicloxacillin Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Effects for Dicloxacillin Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Boneset come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 195 voluntary FDA FAERS reports for Dicloxacillin Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Boneset in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Hepatotoxic PAs are common in this genus of plants; however, the alkaloids in boneset have not been adequately characterized to determine their toxic potential. Hepatotoxic PAs might be teratogenic; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Dicloxacillin Sodium Products Have a Food Rule — Boneset Should Not Break It

At least one FDA label for a product containing Dicloxacillin Sodium says to take it on an empty stomach. Most supplements — Boneset included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Dicloxacillin Sodium on its own and move Boneset to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Dicloxacillin Sodium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Patients weighing less than 40 kg (88 lbs) DRUG ADULTS CHILDREN Mild to Moderate Severe Mild to Moderate Severe Dicloxacillin 125 mg every 6 hours 250 mg every 6 hours 12.5 mg/kg/day 1 in equally divided doses every 6 hours 25 mg/kg/day 1 in equally divided doses every 6 hours Dicloxacillin is best absorbed when taken on an empty stomach, and should be administered at least 1 hour before or 2 hour

From the Dosage and Administration section of the FDA label we read for Dicloxacillin Sodium — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Dicloxacillin Sodium

This page covers Boneset only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dicloxacillin Sodium page lists 56 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), Aristolochia (moderate) and Bacillus Coagulans (moderate).

By severity: 3 major · 42 moderate · 11 minor.

From our pharmacist’s overview on the Dicloxacillin Sodium page

“The riskiest pairing on this page is Siberian cocklebur with dicloxacillin (Dynapen), an antibiotic for staph skin and soft tissue infections. Both can stress the kidneys, and that additive strain accounts for one of the three major ratings among 56 supplements here, enough that this list warrants real care.”

Reviewed by 2 · Jul 18, 2026

Open the Dicloxacillin Sodium interaction page

One more smart check

Taking Boneset as Part of a Dietary Supplement Product? Check It for Interactions

We hold 118 real supplement products containing Boneset, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Boneset. Even though Boneset itself has no known interaction with Dicloxacillin Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Boneset and Dicloxacillin Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Boneset
Top half

#390 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Dicloxacillin Sodium
Top half

#1,010 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Boneset reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Boneset and Dicloxacillin Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Boneset

What is Boneset?

  • Colds and flu
  • Fever
  • Body aches
  • Congestion
  • Immune support

Boneset is a traditional North American herb long used in teas for fevers, colds, and flu, but modern human studies are very limited. It contains compounds (pyrrolizidine alkaloids) that may harm the liver, so it should be used cautiously and avoided during pregnancy and breastfeeding.

Eupatorium perfoliatum · Asteraceae · Dried above-ground parts (leaves and flowering tops) · Tea, tincture, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether Boneset is a good idea for someone in your situation. Here is what our Boneset record says about it on its own.

Boneset: dosing

There is no well-established, standardized dose for boneset. Traditional preparations were usually made as a hot tea from the dried herb, but reliable modern dosing guidelines are not available.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Boneset monograph — the full record covers uses, side effects and every documented interaction.

Read the full Boneset monograph & all interactions
Medication

About Dicloxacillin

What Is Dicloxacillin Used For?

Brand names: Dynapen, Pathocil, Dycill, Pathocil Injection

Dicloxacillin Sodium capsules are used to treat infections caused by staphylococci (staph bacteria) that produce an enzyme called penicillinase, which makes them resistant to ordinary penicillin. It works specifically against these resistant staph strains.

It should not be used for infections caused by bacteria that are still susceptible to regular penicillin G, or for infections caused by organisms other than resistant staphylococci. Lab cultures are used to confirm the right bug is being targeted.

Most-Reported Side Effects for Dicloxacillin Sodium

From FAERS, the FDA’s public side-effect reporting system (195 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Abdominal discomfort 16 reports
Arthralgia 16 reports
Drug hypersensitivity 16 reports
Diarrhea 15 reports
Headache 15 reports
See full Dicloxacillin drug information
Keep checking

Other Drugs & Boneset

Browse every other medication we’ve checked against Boneset — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
87Moderate
0Minor
2,742No known interaction
87 Moderate 2,742 No interaction
Moderate

87 interactions

Showing 60 of 87 moderate interactions — see all 87 on the Boneset page.

No interaction 2,742 drugs checked — show the list

We also checked Boneset against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Boneset list.

See the full Boneset interactions page
See every supplement checked against Dicloxacillin Sodium, ranked by severity
Evidence & sources

Boneset References

The 5 references that drive our Boneset monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  2. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  3. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  4. Gassinger, C. A., Wunstel, G., and Netter, P. [A controlled clinical trial for testing the efficacy of the homeopathic drug eupatorium perfoliatum D2 inthe treatment of common cold (author's transl)]. Arzneimittelforschung. 1981;31(4):732-736.
  5. Colegate SM, Upton R, Gardner DR, Panter KE, Betz JM. Potentially toxic pyrrolizidine alkaloids in Eupatorium perfoliatum and three related species. Implications for herbal use as boneset. Phytochem Anal. 2018;29(6):613-626.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Boneset and Dicloxacillin Sodium Together: Common Questions

Is it safe to take Boneset with Dicloxacillin Sodium?
We do not list a known interaction between Boneset and Dicloxacillin Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Boneset and Dicloxacillin Sodium have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Boneset and Dicloxacillin Sodium at the same time of day?
At least one FDA label for a product containing Dicloxacillin Sodium says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Dicloxacillin Sodium on its own and move Boneset to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Boneset and Dicloxacillin Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Dicloxacillin Sodium is filed under 5 classifications, and Boneset has documented interactions with 1 drug class — none of Dicloxacillin Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Boneset interact with any other medications?
Yes. Boneset has 87 documented drug interactions in our database — Dicloxacillin Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Dicloxacillin Sodium interact with any supplements?
Yes. Dicloxacillin Sodium has documented interactions with 56 supplements in our database — Boneset is not one of them. The Dicloxacillin Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Boneset monograph Uses, safety profile, and every drug interaction in one place Dicloxacillin drug information The full plain-English guide to this medication Dicloxacillin Sodium supplement interactions Every supplement checked against Dicloxacillin Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Dicloxacillin Sodium and Boneset?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.