Drug & supplement interaction

California Poppy + Tofacitinib

Tofacitinib brand names: Xeljanz, Xeljanz XR.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 27, 2026

The bottom line No known interaction

We found no known interaction between California Poppy and Tofacitinib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

California Poppy and Tofacitinib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tofacitinib and California Poppy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

California Poppy safety at a glance

California Poppy overall Use caution Generally considered mild for short-term use, but human safety data are limited.

Pregnancy Avoid Not enough safety data; best avoided during pregnancy.

Breastfeeding Avoid Not enough safety data; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tofacitinib and California Poppy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Tofacitinib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tofacitinib is filed under 4 classifications — including cytochrome p450 2c19 (cyp2c19) substrates, immunosuppressants, cytochrome p450 3a4 (cyp3a4) substrates. California Poppy has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Tofacitinib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

California Poppy Does Interact With Other Medications

California Poppy has 248 moderate known drug interactions in our database — Tofacitinib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Tofacitinib)

Taking anything else?

Check Another of Your Medications Against California Poppy

Covers the 2,830 medications we’ve checked against California Poppy. Pick one to open its full report.

What to actually watch for

What California Poppy Itself Has Been Linked To

This is not an interaction — nothing below involves Tofacitinib. It is the side-effect record for California Poppy on its own, from the licensed Natural Medicines monograph. If something new turns up after you add California Poppy, this list is the first place to look.

Joint or muscle stiffness Additional detail

“There is currently a limited amount of information available about the adverse effects of California poppy.

Most Common Adverse Effects:

Orally: When used in combination with hawthorn and magnesium, California poppy has been reported to cause muscular stiffness, morning fatigue, and nausea. It is not clear if these effects are from California poppy, the other ingredients, or the combination.”

California Poppy · Natural Medicines adverse-effect record, reported in fatigue.
Tiredness Additional detail
“Orally, when used in combination with hawthorn and magnesium, California poppy has been reported to cause morning fatigue. It is not clear if this effect is from California poppy, the other ingredients, or the combination.”

California Poppy · Natural Medicines adverse-effect record, reported in fatigue.
1 source cited

12583. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
Nausea Additional detail
“Orally, when used in combination with hawthorn and magnesium, California poppy has been reported to cause nausea. It is not clear if this effect is from California poppy, the other ingredients, or the combination.”

California Poppy · Natural Medicines adverse-effect record, reported in nausea and vomiting.
1 source cited

12583. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate

Everything above comes from the Natural Medicines adverse-effect record for California Poppy — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Tofacitinib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Tofacitinib column appears here.

Everything else you take

See Every Supplement That Interacts With Tofacitinib

This page covers California Poppy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tofacitinib page lists 184 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Active Hexose Correlated Compound (ahcc) (moderate).

By severity: 3 major · 143 moderate · 38 minor.

From our pharmacist’s overview on the Tofacitinib page

“Supplements deserve genuine care alongside tofacitinib (Xeljanz, Xeljanz XR), a medicine that deliberately dials down the immune system to control conditions like rheumatoid arthritis and ulcerative colitis. Most of the interactions on this page run through the liver enzymes that clear the drug, meaning an herb can push its blood level…”

Reviewed by 2 · Jul 18, 2026

Open the Tofacitinib interaction page

One more smart check

Taking California Poppy as Part of a Dietary Supplement Product? Check It for Interactions

We hold 345 real supplement products containing California Poppy, each one broken down to its full ingredient list — and combination products often carry several ingredients besides California Poppy. Even though California Poppy itself has no known interaction with Tofacitinib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where California Poppy and Tofacitinib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement California Poppy

Top 25%

#332 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Tofacitinib

Steady interest

#1,774 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every California Poppy reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The California Poppy and Tofacitinib records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About California Poppy

What is California Poppy?

Anxiety and stress
Trouble sleeping (insomnia)
Mild aches and pains
Restlessness or nervous tension
Bedwetting in children (traditional use)

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is very limited, so its true benefits are not well proven. It is generally considered mild, but should be avoided during pregnancy and breastfeeding and used with caution by anyone taking sedating medicines.

Eschscholzia californica · Papaveraceae · Above-ground parts (flowers, leaves, stems) and roots · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether California Poppy is a good idea for someone in your situation. Here is what our California Poppy record says about it on its own.

California Poppy: dosing

There is no official, standardized dose for California poppy. Products vary widely in strength, and it is often part of herbal blends. The best approach is to follow the directions on the product label and not exceed the recommended amount.It is commonly taken in the evening when used for sleep, but timing and amount should be guided by the product and your own response.

From our California Poppy monograph — the full record covers uses, side effects and every documented interaction.

Read the full California Poppy monograph & all interactions

Medication

About Tofacitinib

What Is Tofacitinib Used For?

Brand names: Xeljanz, Xeljanz XR

Tofacitinib is used alone or with other medications to treat rheumatoid arthritis (condition in which the body attacks its own joints causing pain, swelling, and loss of function) in adults who are unable to take or did not respond to one or more tumor necrosis factor (TNF) inhibitor medication(s). It is also used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults who are unable to take or did not respond to or tolerate one or more TNF inhibitor medication(s). Tofacitinib is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) in adults who are unable to take or who did not respond to one or more TNF inhibitor medication(s). It is also used to treat polyarticular juvenile idiopathic arthritis (PJIA; a type of childhood arthritis that affects five or more joints during the first six months of the condition, causing pain, swelling, and loss of function) in children 2 years and older who are unable to take or who did not respond to one or more TNF inhibitor medication(s). Tofacitinib is in a class of medications called Janus kinase (JAK) inhibitors. It works by decreasing the activity of the immune system.

Most-Reported Side Effects for Tofacitinib

From FAERS, the FDA’s public side-effect reporting system (186,746 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Arthralgia 20,097 reports

Rheumatoid arthritis 19,517 reports

Fatigue 17,161 reports

Joint swelling 14,867 reports

Headache 13,747 reports

See full Tofacitinib drug information

Keep checking

Other Drugs & California Poppy

Browse every other medication we’ve checked against California Poppy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

248Moderate

0Minor

2,581No known interaction

248 Moderate 2,581 No interaction

Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the California Poppy page.

No interaction 2,581 drugs checked — show the list

We also checked California Poppy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full California Poppy list.

See the full California Poppy interactions page

See every supplement checked against Tofacitinib, ranked by severity

Evidence & sources

California Poppy References

The 3 references that drive our California Poppy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol 2004;485:69-79. PubMed
Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003;789:43-5

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking California Poppy and Tofacitinib Together: Common Questions

Is it safe to take California Poppy with Tofacitinib?

We do not list a known interaction between California Poppy and Tofacitinib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the California Poppy and Tofacitinib combination checked?

Interactions in our licensed database are recorded against drug classes. Tofacitinib is filed under 4 classifications, and California Poppy has documented interactions with 1 drug class — none of Tofacitinib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does California Poppy interact with any other medications?

Yes. California Poppy has 248 documented drug interactions in our database — Tofacitinib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Tofacitinib interact with any supplements?

Yes. Tofacitinib has documented interactions with 184 supplements in our database — California Poppy is not one of them. The Tofacitinib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

California Poppy monograph Uses, safety profile, and every drug interaction in one place Tofacitinib drug information The full plain-English guide to this medication Tofacitinib supplement interactions Every supplement checked against Tofacitinib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tofacitinib and California Poppy?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.