Drug & supplement interaction

California Poppy + Trifluoperazine

Trifluoperazine brand name: Stelazine.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between California Poppy and Trifluoperazine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

California Poppy and Trifluoperazine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Trifluoperazine and California Poppy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

California Poppy safety at a glance

California Poppy overall Use caution Generally considered mild for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough safety data; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety data; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Trifluoperazine and California Poppy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Trifluoperazine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Trifluoperazine is filed under 5 classifications — including phenothiazines, antipsychotic drugs, anticholinergic drugs. California Poppy has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Trifluoperazine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

California Poppy Does Interact With Other Medications

California Poppy has 248 moderate known drug interactions in our database — Trifluoperazine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Trifluoperazine)
Taking anything else?

Check Another of Your Medications Against California Poppy

Covers the 2,830 medications we’ve checked against California Poppy. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests California Poppy and Trifluoperazine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Tiredness Additional detail

    California Poppy

    “Orally, when used in combination with hawthorn and magnesium, California poppy has been reported to cause morning fatigue. It is not clear if this effect is from California poppy, the other ingredients, or the combination.”

    California Poppy · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 12583. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate

    Trifluoperazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Trifluoperazine. Read the label on DailyMed ›

  • Nausea Additional detail

    California Poppy

    “Orally, when used in combination with hawthorn and magnesium, California poppy has been reported to cause nausea. It is not clear if this effect is from California poppy, the other ingredients, or the combination.”

    California Poppy · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 12583. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate

    Trifluoperazine

    Listed in the ADVERSE REACTIONS section of the FDA label for Trifluoperazine. Read the label on DailyMed ›

Reported for California Poppy but not commonly for Trifluoperazine: joint or muscle stiffness.

Effects for Trifluoperazine come from the ADVERSE REACTIONS section of its FDA label; effects for California Poppy come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Trifluoperazine Is Prescribed For, and What California Poppy Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Trifluoperazine is a prescription medicine with approved uses on its FDA label. California Poppy is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Trifluoperazine is prescribed for: Trifluoperazine hydrochloride tablets are used to manage schizophrenia. They are also used for the short-term treatment of generalized non-psychotic anxiety. For anxiety, it is usually not the first medicine tried. Certain risks are not shared by common alternatives such as benzodiazepines.

Read the rest of what Trifluoperazine is prescribed for

It has not been shown to work for behavioral complications in people with mental retardation.

California Poppy has been studied for:

  • Anxiety studied, not established California Poppy has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    California Poppy for anxiety

    Oral California poppy has only been evaluated in combination with other ingredients; its effect when used alone is unclear.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Trifluoperazine on your own; if you are taking California Poppy for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Trifluoperazine

This page covers California Poppy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Trifluoperazine page lists 76 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Henbane (major), Indian Snakeroot (major), Rauvolfia Vomitoria (major) and Scopolia (major).

By severity: 5 major · 48 moderate · 23 minor.

From our pharmacist’s overview on the Trifluoperazine page

“An antipsychotic like trifluoperazine (Stelazine) leaves little slack for supplements that pile on side effects, and this list deserves a careful read. Five of the 76 ingredients on file rate major, and the largest cluster, 30 ingredients, adds anticholinergic load to a drug that already tends to cause dry mouth, constipation, and conf…”

Reviewed by 2 · Jul 18, 2026

Open the Trifluoperazine interaction page

One more smart check

Taking California Poppy as Part of a Dietary Supplement Product? Check It for Interactions

We hold 345 real supplement products containing California Poppy, each one broken down to its full ingredient list — and combination products often carry several ingredients besides California Poppy. Even though California Poppy itself has no known interaction with Trifluoperazine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where California Poppy and Trifluoperazine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement California Poppy
Top 25%

#329 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Trifluoperazine
Steady interest

#2,716 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every California Poppy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The California Poppy and Trifluoperazine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About California Poppy

What is California Poppy?

California Poppy
  • Anxiety and stress
  • Trouble sleeping (insomnia)
  • Mild aches and pains
  • Restlessness or nervous tension
  • Bedwetting in children (traditional use)

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is very limited, so its true benefits are not well proven. It is generally considered mild, but should be avoided during pregnancy and breastfeeding and used with caution by anyone taking sedating medicines.

Eschscholzia californica · Papaveraceae · Above-ground parts (flowers, leaves, stems) and roots · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether California Poppy is a good idea for someone in your situation. Here is what our California Poppy record says about it on its own.

California Poppy: dosing

There is no official, standardized dose for California poppy. Products vary widely in strength, and it is often part of herbal blends. The best approach is to follow the directions on the product label and not exceed the recommended amount.It is commonly taken in the evening when used for sleep, but timing and amount should be guided by the product and your own response.

From our California Poppy monograph — the full record covers uses, side effects and every documented interaction.

Read the full California Poppy monograph & all interactions
Medication

About Trifluoperazine

What Is Trifluoperazine Used For?

Brand name: Stelazine

Trifluoperazine hydrochloride tablets are used to manage schizophrenia. They are also used for the short-term treatment of generalized non-psychotic anxiety.

For anxiety, it is usually not the first medicine tried. Certain risks are not shared by common alternatives such as benzodiazepines. It has not been shown to work for behavioral complications in people with mental retardation.

See full Trifluoperazine drug information
Keep checking

Other Drugs & California Poppy

Browse every other medication we’ve checked against California Poppy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the California Poppy page.

No interaction 2,581 drugs checked — show the list

We also checked California Poppy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full California Poppy list.

See the full California Poppy interactions page
See every supplement checked against Trifluoperazine, ranked by severity
Evidence & sources

California Poppy References

The 3 references that drive our California Poppy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
  2. Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol 2004;485:69-79. PubMed
  3. Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003;789:43-5

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking California Poppy and Trifluoperazine Together: Common Questions

Is it safe to take California Poppy with Trifluoperazine?
We do not list a known interaction between California Poppy and Trifluoperazine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do California Poppy and Trifluoperazine have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are California Poppy and Trifluoperazine used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for California Poppy in each. That is a conversation for your prescriber, especially if Trifluoperazine is being adjusted to a target.
How was the California Poppy and Trifluoperazine combination checked?
Interactions in our licensed database are recorded against drug classes. Trifluoperazine is filed under 5 classifications, and California Poppy has documented interactions with 1 drug class — none of Trifluoperazine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does California Poppy interact with any other medications?
Yes. California Poppy has 248 documented drug interactions in our database — Trifluoperazine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Trifluoperazine interact with any supplements?
Yes. Trifluoperazine has documented interactions with 76 supplements in our database — California Poppy is not one of them. The Trifluoperazine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

California Poppy monograph Uses, safety profile, and every drug interaction in one place Trifluoperazine drug information The full plain-English guide to this medication Trifluoperazine supplement interactions Every supplement checked against Trifluoperazine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Trifluoperazine and California Poppy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.