Drug & supplement interaction

Catnip + Lemborexant

Lemborexant brand name: Dayvigo.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Catnip has a moderate interaction with Lemborexant. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Catnip and Lemborexant

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Lemborexant

Lemborexant falls under CNS DEPRESSANTS — the group Catnip interacts with.

Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.
Clinical and animal research shows that catnip has sedative properties.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: Dayvigo (lemborexant) already works by calming brain activity to help you fall and stay asleep. Catnip, used as a tea or supplement, is thought to have its own mild calming, sleepy effect. Put the two together and those effects can stack up. This isn't about catnip changing how your liver breaks the drug down, it's more about doubling up on sleepiness.

In real life that could mean feeling extra drowsy or groggy the next morning, being unsteady on your feet, or having trouble thinking clearly. Honestly, the evidence here is on the weak side (mostly anecdotal and animal studies), so I'm not ringing alarm bells. Still, since lemborexant can already cause next-day drowsiness, it's worth a quick chat with your pharmacist or doctor before pairing the two.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Osterhoudt KC, Lee SK, Callahan JM, Henretig FM. Catnip and the alteration of human consciousness. Vet Hum Toxicol 1997;39:373-5.
  3. Sherry, C. J. and Hunter, P. S. The effect of an ethanol extract of catnip (Nepeta cataria) on the behavior of the young chick. Experientia 2-15-1979;35(2):237-238. PubMed
  4. Harney, J. W., Barofsky, I. M., and Leary, J. D. Behavioral and toxicological studies of cyclopentanoid monoterpenes from Nepeta cataria. Lloydia. 1978;41(4):367-374.
  5. Massoco, C. O., Silva, M. R., Gorniak, S. L., Spinosa, M. S., and Bernardi, M. M. Behavioral effects of acute and long-term administration of catnip (Nepeta cataria) in mice. Vet.Hum.Toxicol 1995;37(6):530-533.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Catnip Also Interacts With Other Medications

Catnip has 247 moderate known drug interactions in our database — the Lemborexant one above is one of them. If you take anything else, check it against the full list below.

Moderate 247 No known interaction 2,583 (incl. Lemborexant)
Taking anything else?

Check Another of Your Medications Against Catnip

Covers the 2,830 medications we’ve checked against Catnip. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Lemborexant

This page covers Catnip only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Lemborexant page lists 195 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 147 moderate · 39 minor.

From our pharmacist’s overview on the Lemborexant page

“Lemborexant (Dayvigo) works by quieting the brain's wake signals, so the biggest risks on this list come from anything else that sedates you. Alcohol sits at the top; a drink layered over a dose can deepen drowsiness into real impairment, and a few entries carry the added danger of slowed breathing.”

Reviewed by 2 · Jul 18, 2026

Open the Lemborexant interaction page

One more smart check

Taking Catnip as Part of a Dietary Supplement Product? Check It for Interactions

We hold 295 real supplement products containing Catnip, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Catnip. Your product may carry other ingredients that interact with Lemborexant too, on top of Catnip — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Catnip and Lemborexant Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Catnip
Steady interest

#936 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Lemborexant
Top 10%

#168 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Catnip

What is Catnip?

Catnip
  • Sleep and insomnia
  • Anxiety and stress
  • Digestive upset
  • Cold and flu symptoms
  • Insect repellent

Catnip is a mint-family herb most often used as a calming tea for sleep, anxiety, and minor digestive upset, but solid human research supporting these uses is lacking. It is generally considered fairly safe in small culinary or tea amounts for most adults, but it should be avoided during pregnancy and used cautiously otherwise. Talk to your pharmacist or doctor before using it, especially if you take medications or have a health condition.

Read the full Catnip monograph & all interactions
Medication

About Lemborexant

What Is Lemborexant Used For?

Brand name: Dayvigo

Dayvigo (lemborexant) is used to treat insomnia in adults. It helps people who have trouble falling asleep, staying asleep, or both.

It is not approved for use in children. Only the oral tablet form is available under the brand name Dayvigo.

See full Lemborexant drug information
Keep checking

Other Drugs & Catnip

Browse every other medication we’ve checked against Catnip — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
247Moderate
0Minor
2,582No known interaction
247 Moderate 2,582 No interaction
Moderate

247 interactions

Showing 60 of 247 moderate interactions — see all 247 on the Catnip page.

No interaction 2,582 drugs checked — show the list

We also checked Catnip against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,582 medications checked with no known interaction — see the full Catnip list.

See the full Catnip interactions page
See every supplement checked against Lemborexant, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Catnip monograph › Uses, safety, and every drug interaction in one place Lemborexant supplement interactions › Every supplement checked against Lemborexant, ranked by severity Lemborexant drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Catnip and Lemborexant Together: Common Questions

Can you take Catnip with Lemborexant?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Catnip and Lemborexant interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Lemborexant and Catnip?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.