Drug & supplement interaction

Cauliflower + Voxelotor

Voxelotor brand name: Oxbryta.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Cauliflower and Voxelotor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Cauliflower and Voxelotor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Voxelotor and Cauliflower in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cauliflower safety at a glance

Cauliflower overall Generally safe Cauliflower is safe and nutritious for most people when eaten as a food.
Pregnancy Generally safe Cauliflower as a normal food is considered safe in pregnancy; concentrated supplements are not well studied.
Breastfeeding Generally safe Eating cauliflower is generally safe while breastfeeding, though some parents notice it makes babies gassier.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Voxelotor and Cauliflower? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Voxelotor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Voxelotor is filed under 3 classifications — cytochrome p450 3a4 (cyp3a4) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Cauliflower has documented interactions with 1 drug class — the most serious being cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Voxelotor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cauliflower Does Interact With Other Medications

Cauliflower has 186 moderate known drug interactions in our database — Voxelotor isn’t one of them. If you take anything else, check it against the full list below.

Moderate 186 No known interaction 2,644 (incl. Voxelotor)
Taking anything else?

Check Another of Your Medications Against Cauliflower

Covers the 2,830 medications we’ve checked against Cauliflower. Pick one to open its full report.

What to actually watch for

What Voxelotor’s Own FDA Label Lists

This is not an interaction — none of it involves Cauliflower. These are the most notable effects listed in the ADVERSE REACTIONS section of Voxelotor’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 2 of them are worth acting on rather than waiting out — marked below.

  • Hives Worth acting on
  • An allergic reaction Worth acting on
  • Diarrhea mentioned in 14.3% of FDA reports for Voxelotor
  • Stomach pain mentioned in 5.3% of FDA reports for Voxelotor
  • Fever
  • Headache mentioned in 7.6% of FDA reports for Voxelotor
  • Nausea mentioned in 9.0% of FDA reports for Voxelotor
  • A skin rash

From the ADVERSE REACTIONS section of the FDA label for Voxelotor. Read the label on DailyMed › Where a percentage is shown, it is the share of 22,291 voluntary FDA FAERS reports for Voxelotor that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Cauliflower’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Cauliflower side to compare — that is a limit of the record, not a statement that Cauliflower has no side effects.

Everything else you take

See Every Supplement That Interacts With Voxelotor

This page covers Cauliflower only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Voxelotor page lists 143 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 40 minor.

From our pharmacist’s overview on the Voxelotor page

“Anyone taking voxelotor (Oxbryta) for sickle cell disease should treat this list with real care, because the pattern behind it is unusually consistent. Almost every entry works through CYP3A4, the same liver enzyme that clears voxelotor, so these ingredients can push the drug's blood level higher or pull it lower, either adding side ef…”

Reviewed by 2 · Jul 18, 2026

Open the Voxelotor interaction page

One more smart check

Taking Cauliflower as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,705 real supplement products containing Cauliflower, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cauliflower. Even though Cauliflower itself has no known interaction with Voxelotor, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cauliflower and Voxelotor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cauliflower
Top 25%

#270 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Voxelotor
Steady interest

#2,678 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cauliflower reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cauliflower and Voxelotor records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Cauliflower

What is Cauliflower?

  • General nutrition and a low-carb vegetable
  • Source of vitamin C and fiber
  • Antioxidant support
  • Digestive and gut health
  • Part of a heart-healthy diet

Cauliflower is a nutritious cruciferous vegetable that provides vitamin C, fiber, and plant compounds called glucosinolates. As a food it is healthy and safe for most people, but there is no strong proof that cauliflower supplements treat or prevent any specific disease. Enjoy it as part of a balanced diet rather than relying on pills.

Brassica oleracea var. botrytis · Brassicaceae · Edible flower head (curd); leaves and stalk are also eaten · Fresh or frozen vegetable, cooked dishes, riced cauliflower, powder, and capsules or extracts

An interaction check asks whether these two react with each other — it does not ask whether Cauliflower is a good idea for someone in your situation. Here is what our Cauliflower record says about it on its own.

Cauliflower: dosing

There is no established medicinal dose for cauliflower. As a food, it is simply included as one of several vegetable servings in a balanced diet, and there is no specific amount you must reach to be healthy.For cauliflower powders, capsules, or extracts, follow the directions on the product label, since strengths vary widely between products and none is standardized.

From our Cauliflower monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cauliflower monograph & all interactions
Medication

About Voxelotor

What Is Voxelotor Used For?

Brand name: Oxbryta

Oxbryta (voxelotor) is approved to treat sickle cell disease (SCD) in adults and in children as young as 4 years old. It works by targeting the underlying problem in sickle cell disease — the abnormal hemoglobin that causes red blood cells to take on a rigid, sickle shape.

This approval was granted under the FDA's accelerated approval pathway, based on the drug's ability to raise hemoglobin levels. Continued approval may depend on results from confirmatory clinical trials showing broader clinical benefit.

Most-Reported Side Effects for Voxelotor

From FAERS, the FDA’s public side-effect reporting system (22,300 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Sickle cell anaemia with crisis 11,218 reports
Diarrhea 3,187 reports
Nausea 2,016 reports
Headache 1,691 reports
Abdominal pain upper 1,171 reports
See full Voxelotor drug information
Keep checking

Other Drugs & Cauliflower

Browse every other medication we’ve checked against Cauliflower — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
186Moderate
0Minor
2,643No known interaction
186 Moderate 2,643 No interaction
Moderate

186 interactions

Showing 60 of 186 moderate interactions — see all 186 on the Cauliflower page.

No interaction 2,643 drugs checked — show the list

We also checked Cauliflower against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,643 medications checked with no known interaction — see the full Cauliflower list.

See the full Cauliflower interactions page
See every supplement checked against Voxelotor, ranked by severity
Evidence & sources

Cauliflower References

The 9 references that drive our Cauliflower monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joshipura KJ, Ascherio A, Manson JE, et al. Fruit and vegetable intake in relation to risk of ischemic stroke. JAMA 1999;282:1233-39. PubMed
  2. Zhao H, Lin J, Grossman HB, et al. Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer risk. Int J Cancer 2007;120:2208-13.
  3. Cohen, J. H., Kristal, A. R., and Stanford, J. L. Fruit and vegetable intakes and prostate cancer risk. J Natl.Cancer Inst. 1-5-2000;92(1):61-68. PubMed
  4. Michaud DS, Spiegelman D, Clinton SK, et al. Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort. J Natl Cancer Inst 1999;91(7):605-13. PubMed
  5. Feskanich D, Ziegler RG, Michaud DS, et al. Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. J Natl Cancer Inst 2000;92(22):1812-23. PubMed
  6. Chang ET, Smedby KE, Zhang SM, et al. Dietary factors and risk of non-Hodgkin lymphoma in men and women. Cancer Epidemiol Biomarkers Prev 2005;14(2):512-20. PubMed
  7. Liu S, Serdula M, Janket SJ, et al. A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women. Diabetes Care 2004;27(12):2993-6. PubMed
  8. Gaudet MM, Britton JA, Kabat GC, et al. Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor status. Cancer Epidemiol Biomarkers Prev 2004;13(9):1485-94. DOI
  9. Peterson S, Schwarz Y, Li SS, et al. CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. Cancer Epidemiol Biomarkers Prev 2009;18(11):3118-25.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Cauliflower and Voxelotor Together: Common Questions

Is it safe to take Cauliflower with Voxelotor?
We do not list a known interaction between Cauliflower and Voxelotor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Cauliflower and Voxelotor combination checked?
Interactions in our licensed database are recorded against drug classes. Voxelotor is filed under 3 classifications, and Cauliflower has documented interactions with 1 drug class — none of Voxelotor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Cauliflower interact with any other medications?
Yes. Cauliflower has 186 documented drug interactions in our database — Voxelotor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Voxelotor interact with any supplements?
Yes. Voxelotor has documented interactions with 143 supplements in our database — Cauliflower is not one of them. The Voxelotor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Cauliflower monograph Uses, safety profile, and every drug interaction in one place Voxelotor drug information The full plain-English guide to this medication Voxelotor supplement interactions Every supplement checked against Voxelotor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 9 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Voxelotor and Cauliflower?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.