Drug & supplement interaction

Ceylon Cinnamon + Phenoxybenzamine

Phenoxybenzamine brand name: Dibenzyline.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Ceylon Cinnamon has a moderate interaction with Phenoxybenzamine. Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Ceylon Cinnamon and Phenoxybenzamine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIHYPERTENSIVE DRUGS

Why this applies to Phenoxybenzamine

Phenoxybenzamine falls under ANTIHYPERTENSIVE DRUGS — the group Ceylon Cinnamon interacts with.

Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version. Phenoxybenzamine already lowers blood pressure by blocking alpha receptors, which is exactly why it's used for the surges from a pheochromocytoma. Ceylon cinnamon, at least in lab and animal studies, seems to relax blood vessels too. So the worry is that the two could stack on each other and push your blood pressure a little too low.

If that happened, you might feel dizzy, lightheaded, faint when you stand up, or notice a fast heartbeat (effects phenoxybenzamine can already cause). I'll be honest though: this is theoretical and based on animal research, not human studies. A sprinkle of cinnamon on your food is very unlikely to matter. Concentrated cinnamon capsules are worth running past your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
  2. Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Ceylon Cinnamon Also Interacts With Other Medications

Ceylon Cinnamon has 257 moderate known drug interactions in our database — the Phenoxybenzamine one above is one of them. If you take anything else, check it against the full list below.

Moderate 257 No known interaction 2,573 (incl. Phenoxybenzamine)
Taking anything else?

Check Another of Your Medications Against Ceylon Cinnamon

Covers the 2,830 medications we’ve checked against Ceylon Cinnamon. Pick one to open its full report.

From our Q&A

Questions About Ceylon Cinnamon or Phenoxybenzamine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Ceylon Cinnamon or Phenoxybenzamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Phenoxybenzamine

This page covers Ceylon Cinnamon only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Phenoxybenzamine page lists 137 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 112 moderate · 21 minor.

From our pharmacist’s overview on the Phenoxybenzamine page

“Phenoxybenzamine (Dibenzyline) is usually prescribed for pheochromocytoma, an adrenal tumor that sends blood pressure surging, often to steady a patient in the weeks before surgery, so keeping pressure in a narrow band is the entire goal of treatment. That makes this a list to treat carefully rather than skim.”

Reviewed by 2 · Jul 18, 2026

Open the Phenoxybenzamine interaction page

One more smart check

Taking Ceylon Cinnamon as Part of a Dietary Supplement Product? Check It for Interactions

We hold 362 real supplement products containing Ceylon Cinnamon, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Ceylon Cinnamon. Your product may carry other ingredients that interact with Phenoxybenzamine too, on top of Ceylon Cinnamon — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Ceylon Cinnamon and Phenoxybenzamine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Ceylon Cinnamon
Top 25%

#338 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Phenoxybenzamine
Top half

#742 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Ceylon Cinnamon

What is Ceylon Cinnamon?

Ceylon Cinnamon
  • Blood sugar support
  • High cholesterol
  • Indigestion and gas
  • Antimicrobial
  • General flavoring and culinary use

Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evidence for most health benefits is limited and mixed, but as a food it is generally safe and contains far less coumarin than common cassia cinnamon. Talk with your pharmacist or doctor before taking concentrated supplements, especially if you have a health condition or take medications.

Read the full Ceylon Cinnamon monograph & all interactions
Medication

About Phenoxybenzamine

What Is Phenoxybenzamine Used For?

Brand name: Dibenzyline

Phenoxybenzamine hydrochloride capsules are used to treat pheochromocytoma — a rare tumor of the adrenal gland that releases large bursts of stress hormones, causing dangerous spikes in blood pressure and heavy sweating. The capsules help keep those episodes under control.

If the heart rate becomes too fast during treatment, a doctor may also prescribe a beta-blocker alongside phenoxybenzamine.

See full Phenoxybenzamine drug information
Keep checking

Other Drugs & Ceylon Cinnamon

Browse every other medication we’ve checked against Ceylon Cinnamon — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
257Moderate
0Minor
2,572No known interaction
257 Moderate 2,572 No interaction
Moderate

257 interactions

Showing 60 of 257 moderate interactions — see all 257 on the Ceylon Cinnamon page.

No interaction 2,572 drugs checked — show the list

We also checked Ceylon Cinnamon against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,572 medications checked with no known interaction — see the full Ceylon Cinnamon list.

See the full Ceylon Cinnamon interactions page
See every supplement checked against Phenoxybenzamine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Ceylon Cinnamon monograph › Uses, safety, and every drug interaction in one place Phenoxybenzamine supplement interactions › Every supplement checked against Phenoxybenzamine, ranked by severity Phenoxybenzamine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Ceylon Cinnamon and Phenoxybenzamine Together: Common Questions

Can you take Ceylon Cinnamon with Phenoxybenzamine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Ceylon Cinnamon and Phenoxybenzamine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Phenoxybenzamine and Ceylon Cinnamon?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.