Drug & supplement interaction

Coriander + Hydralazine, Hydrochlorothiazide, Reserpine

Hydralazine, Hydrochlorothiazide, Reserpine brand names: Ser-Ap-Es, Unipres, Uniserp.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Hydralazine, Hydrochlorothiazide, Reserpine falls into 2 drug categories that Coriander can interact with; the most serious is rated moderate. Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
Interactions2
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Coriander and Hydralazine, Hydrochlorothiazide, Reserpine

These two interact in 2 distinct ways. Each one is explained separately below.

Why Are There 2 Interactions?

Coriander interacts with whole categories of medication. Hydralazine, Hydrochlorothiazide, Reserpine falls into 2 of those categories, so it can interact with Coriander in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).

Moderate

ANTIHYPERTENSIVE DRUGS

1 of 2

Why this applies to Hydralazine, Hydrochlorothiazide, Reserpine

Hydralazine, Hydrochlorothiazide, Reserpine falls under ANTIHYPERTENSIVE DRUGS — the group Coriander interacts with.

Theoretically, coriander might increase the risk of hypotension when taken with antihypertensive drugs.
Evidence from animal research suggests that coriander fruit can lower blood pressure.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination pill already does a lot of work to lower your blood pressure. It pairs three different actions: hydralazine relaxes your blood vessels, hydrochlorothiazide (a water pill) helps you shed extra fluid, and reserpine calms certain nerve signals. Coriander may add a small blood-pressure-lowering nudge on top of that. The catch is that this idea comes only from animal studies, so we really don't know how meaningful it is in people.

If your pressure dipped too low, you might feel dizzy, lightheaded, or faint, especially when standing up quickly. Everyday cooking amounts of cilantro are very unlikely to cause trouble. Concentrated extracts or essential oils are the bigger question mark, so please check with your pharmacist or doctor before using those.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Jabeen, Q., Bashir, S., Lyoussi, B., and Gilani, A. H. Coriander fruit exhibits gut modulatory, blood pressure lowering and diuretic activities. J Ethnopharmacol. 2-25-2009;122(1):123-130. PubMed
Moderate

PHOTOSENSITIZING DRUGS

2 of 2

Hydralazine, Hydrochlorothiazide, Reserpine also falls under PHOTOSENSITIZING DRUGS.

Theoretically, coriander might increase the risk of photosensitivity when taken with photosensitizing drugs.
Evidence from in vitro research suggests that coriandrin, a constituent of coriander, has photosensitizing effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for this combo pill (hydralazine, hydrochlorothiazide, and reserpine). One of its ingredients, hydrochlorothiazide, is a water pill that's already known to make some people's skin more sensitive to the sun, so they sunburn faster than usual. Coriander, in theory, may add a little to that sun-sensitivity because of a plant compound called coriandrin.

I want to be honest about how thin this evidence is. It comes mostly from lab studies, not real patients, so the everyday cilantro on your tacos is very unlikely to cause trouble. The bigger question would be concentrated coriander extracts or essential oils. To play it safe, wear sunscreen and a hat outdoors, and ask your pharmacist before adding any coriander supplement.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Ashwood-Smith, M. J., Warrington, P. J., Jenkins, M., Ceska, O., and Romaniuk, P. J. Photobiological properties of a novel, naturally occurring furoisocoumarin, coriandrin. Photochem.Photobiol. 1989;50(6):745-751. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Coriander Also Interacts With Other Medications

Coriander has 716 moderate known drug interactions in our database — the Hydralazine, Hydrochlorothiazide, Reserpine one above is among them. If you take anything else, check it against the full list below.

Moderate 716 No known interaction 2,114 (incl. Hydralazine, Hydrochlorothiazide, Reserpine)
Taking anything else?

Check Another of Your Medications Against Coriander

Covers the 2,830 medications we’ve checked against Coriander. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Hydralazine, Hydrochlorothiazide, Reserpine

This page covers Coriander only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Hydralazine, Hydrochlorothiazide, Reserpine page lists 231 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Dolomite (major).

By severity: 10 major · 196 moderate · 25 minor.

From our pharmacist’s overview on the Hydralazine, Hydrochlorothiazide, Reserpine page

“Ser-Ap-Es combines three blood pressure drugs, hydralazine, hydrochlorothiazide, and reserpine, so this list deserves real attention before you add a supplement. Most of the 231 ingredients on file either push blood pressure down further than intended or pile onto the diuretic and drag potassium and fluid levels with it.”

Reviewed by 2 · Jul 18, 2026

Open the Hydralazine, Hydrochlorothiazide, Reserpine interaction page

One more smart check

Taking Coriander as Part of a Dietary Supplement Product? Check It for Interactions

We hold 934 real supplement products containing Coriander, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coriander. Your product may carry other ingredients that interact with Hydralazine, Hydrochlorothiazide, Reserpine too, on top of Coriander — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coriander and Hydralazine, Hydrochlorothiazide, Reserpine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coriander
Top 25%

#291 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Hydralazine, Hydrochlorothiazide, Reserpine
Steady interest

#2,292 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Coriander

What is Coriander?

Coriander
  • Digestive upset and gas
  • Appetite stimulation
  • Mild antimicrobial (topical)
  • Diarrhea and IBS symptoms
  • General flavoring and traditional remedy

Coriander (also called cilantro) is a common cooking herb and spice that has long been used in traditional medicine for digestive complaints. As a food it is generally safe for most people, but high-quality human studies supporting its medicinal benefits are limited. Talk with your pharmacist or doctor before using concentrated extracts or essential oils.

Read the full Coriander monograph & all interactions
Keep checking

Other Drugs & Coriander

Browse every other medication we’ve checked against Coriander — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
716Moderate
0Minor
2,113No known interaction
716 Moderate 2,113 No interaction
Moderate

716 interactions

Showing 60 of 716 moderate interactions — see all 716 on the Coriander page.

No interaction 2,113 drugs checked — show the list

We also checked Coriander against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,113 medications checked with no known interaction — see the full Coriander list.

See the full Coriander interactions page
See every supplement checked against Hydralazine, Hydrochlorothiazide, Reserpine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Coriander monograph › Uses, safety, and every drug interaction in one place Hydralazine, Hydrochlorothiazide, Reserpine supplement interactions › Every supplement checked against Hydralazine, Hydrochlorothiazide, Reserpine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Coriander and Hydralazine, Hydrochlorothiazide, Reserpine Together: Common Questions

Can you take Coriander with Hydralazine, Hydrochlorothiazide, Reserpine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 2 interactions listed for Coriander and Hydralazine, Hydrochlorothiazide, Reserpine?
Hydralazine, Hydrochlorothiazide, Reserpine belongs to more than one drug category, and Coriander interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Coriander and Hydralazine, Hydrochlorothiazide, Reserpine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Hydralazine, Hydrochlorothiazide, Reserpine and Coriander?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.