Devil's Club + Salmeterol
Salmeterol brand name: Serevent.
We found no known interaction between Devil's Club and Salmeterol in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Salmeterol states a food rule worth keeping to.
Devil's Club and Salmeterol
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Salmeterol and Devil's Club in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
Worth understanding: our licensed dataset holds no drug-interaction record for Devil's Club at all — not against Salmeterol, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Devil's Club safety at a glance
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Some Salmeterol Products Have a Food Rule — Devil's Club Should Not Break It
At least one FDA label for a product containing Salmeterol says to take it on an empty stomach. Most supplements — Devil's Club included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Salmeterol on its own and move Devil's Club to a meal later in the day.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Salmeterol products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
One inhalation of SEREVENT DISKUS at least 30 minutes before exercise has been shown to protect patients against EIB.
From the Dosage and Administration section of the FDA label we read for Salmeterol — where that label names a specific product, the instruction is that product's. See the Salmeterol drug page ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
See Every Supplement That Interacts With Salmeterol
This page covers Devil's Club only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Salmeterol page lists 141 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: American Hellebore (major), Arsenic (major), Cesium (major), Ephedra (major) and Grapefruit (major).
By severity: 7 major · 105 moderate · 29 minor.
From our pharmacist’s overview on the Salmeterol page
“Salmeterol (Serevent) is the long-acting inhaler taken twice daily for asthma or COPD, and its supplement list is one I would approach with real caution. Seven of the 141 ingredients on file rate major: grapefruit can raise salmeterol levels by blocking the enzyme that clears it, St.”
Reviewed by 2 · Jul 18, 2026
Taking Devil's Club as Part of a Dietary Supplement Product? Check It for Interactions
We hold 48 real supplement products containing Devil's Club, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Devil's Club. Even though Devil's Club itself has no known interaction with Salmeterol, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Devil's Club and Salmeterol Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#923 of 1,452 supplements looked up here in the last 7 days
#2,546 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Devil's Club reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Devil's Club and Salmeterol records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Devil's Club
What is Devil's Club?
- Blood sugar support
- Respiratory and cold symptoms
- Arthritis and joint pain
- Digestive complaints
- General tonic and wellness
Devil's Club is a thorny shrub from the Pacific Northwest of North America that has long been used in Indigenous traditional medicine, especially for blood sugar and respiratory complaints. Scientific evidence in humans is very limited, so its benefits are not proven. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.
Oplopanax horridus · Araliaceae · Root bark, stem bark, and inner bark · Tea or decoction, tincture, capsules, dried bark, topical salves
An interaction check asks whether these two react with each other — it does not ask whether Devil's Club is a good idea for someone in your situation. Here is what our Devil's Club record says about it on its own.
Devil's Club: dosing
There is no established standard dose for Devil's Club. The right amount has not been determined in clinical studies, and product strength can vary widely between brands and forms (tea, tincture, or capsule).If you choose to use it, follow the directions on the product label and do not exceed the suggested amount.
From our Devil's Club monograph — the full record covers uses, side effects and every documented interaction.
About Salmeterol Oral Inhalation
What Is Salmeterol Oral Inhalation Used For?
Brand name: Serevent
Serevent Diskus (salmeterol inhalation powder) is used for three main purposes: treating asthma in patients aged 4 and older alongside an inhaled corticosteroid (ICS), preventing exercise-induced bronchospasm (EIB) in patients aged 4 and older, and providing long-term maintenance treatment of bronchospasm associated with COPD — including chronic bronchitis and emphysema — in adults.
Important: Serevent Diskus is not a rescue inhaler. It will not relieve a sudden asthma or COPD attack. For asthma, it must always be used together with an inhaled corticosteroid — using it alone for asthma is contraindicated due to a serious risk of asthma-related death.
Other Drugs & Devil's Club
Browse every other medication we’ve checked against Devil's Club — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
No interaction 2,829 drugs checked — show the list
We also checked Devil's Club against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Abemaciclib ›
- Aspirin ›
- Acetaminophen ›
- Metoprolol ›
- Rosuvastatin ›
- Rivaroxaban ›
- Escitalopram ›
- Clopidogrel ›
- Atorvastatin ›
- Tadalafil ›
- Docusate ›
- Tirzepatide ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Valacyclovir ›
- Warfarin Sodium ›
- Sumatriptan ›
- Semaglutide ›
- Prednisone ›
- Lisdexamfetamine ›
- Propranolol ›
- Metformin ›
- Amitriptyline ›
- Amoxicillin ›
- Lisinopril ›
- Isotretinoin ›
- Amlodipine Besylate ›
- Methotrexate ›
- Bendamustine ›
- Bupropion ›
- Amphetamine ›
- Doxycycline ›
- Fluoxetine ›
- Acyclovir ›
- Azithromycin ›
- Lamotrigine ›
- Pregabalin ›
- Dextroamphetamine ›
- Gabapentin ›
- Acetaminophen, Codeine ›
- Quetiapine ›
- Clonazepam ›
- Levothyroxine, Liothyronine ›
- Naproxen ›
- Omeprazole ›
- Letrozole ›
- Methylene Blue ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Devil's Club list.
Devil's Club References
The 2 references that drive our Devil's Club monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Turner NJ, Thompson LC Thompson MT York AZ. Thompson Ethnobotany: Knowledge and Usage of Plants by the Thompson Indians of British Columbia. 1990.
- Thommasen HV, Wilson RA, McIlwain RG. Effect of Devil's Club Tea on Blood Glucose Levels in Diabetes Mellitus. Can Fam Physician. 1990;36:62-5.
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Devil's Club and Salmeterol Together: Common Questions
Is it safe to take Devil's Club with Salmeterol?
Should I take Devil's Club and Salmeterol at the same time of day?
Does Salmeterol interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.