Drug & supplement interaction

Dymethazine + Methazolamide

Methazolamide brand name: Neptazane.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Dymethazine and Methazolamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Dymethazine and Methazolamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methazolamide and Dymethazine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Dymethazine at all — not against Methazolamide, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dymethazine safety at a glance

Dymethazine overall Avoid Dymethazine is a designer anabolic steroid with serious liver and hormonal risks and is best avoided entirely.
Pregnancy Possibly Unsafe When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss,... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss,... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methazolamide and Dymethazine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

No Interaction Found — But Data Suggests Dymethazine and Methazolamide May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Liver problems Worth acting on Additional detail

    Dymethazine

    “Orally, dymethazine is possibly unsafe. As an anabolic androgenic steroid, there is concern that it might cause serious side effects including stroke, kidney failure, and liver injury.”

    Dymethazine · Natural Medicines adverse-effect record, reported in kidney failure.

    “There is a case of cholestatic jaundice with elevated liver enzymes, dark urine, clay stools, and pruritus in a 26-year-old male, likely related to the use of a product (Super DMZ Rx 2.0) containing methylstenbolone 10 mg and dymethazine 10 mg per capsule. The product was used at manufacturer-recommended doses of two capsules daily for up to one month. Liver enzyme levels gradually decreased after discontinuation.”

    Dymethazine · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 108298. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed

    Methazolamide

    Listed in the ADVERSE REACTIONS section of the FDA label for Methazolamide. Read the label on DailyMed ›

Reported for Dymethazine but not commonly for Methazolamide: kidney problems, itching and yellowing of the skin or eyes.

Effects for Methazolamide come from the ADVERSE REACTIONS section of its FDA label; effects for Dymethazine come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 339 voluntary FDA FAERS reports for Methazolamide that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Dymethazine in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Anabolic androgenic steroids can disrupt the body's hormonal balance and cause various adverse effects including reduced fertility, hair loss, acne, and behavioral changes. Anabolic androgenic steroid use has also been associated with hepatotoxicity and increased risk for heart disease. The U.S. Food and Drug Administration and other regulatory agencies warn that dietary supplements containing anabolic steroids are dangerous. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Methazolamide

This page covers Dymethazine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methazolamide page lists 218 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Lithium (major) and Oleander (major).

By severity: 7 major · 187 moderate · 24 minor.

From our pharmacist’s overview on the Methazolamide page

“Methazolamide (Neptazane) treats glaucoma by lowering pressure inside the eye, and because it also has mild water-pill effects it can nudge blood pressure and potassium on its own. That is exactly where most of the 218 supplements on this page press, and the list earns real caution.”

Reviewed by 2 · Jul 18, 2026

Open the Methazolamide interaction page

One more smart check

Taking Dymethazine as Part of a Dietary Supplement Product? Check It for Interactions

We hold 18 real supplement products containing Dymethazine, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dymethazine. Even though Dymethazine itself has no known interaction with Methazolamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dymethazine and Methazolamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dymethazine
Steady interest

#1,029 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methazolamide
Steady interest

#2,387 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dymethazine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Dymethazine and Methazolamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dymethazine

What is Dymethazine?

  • Muscle building
  • Strength gains
  • Bodybuilding bulking cycles
  • Performance enhancement

Dymethazine is a synthetic anabolic-androgenic steroid (a so-called 'prohormone' or 'designer steroid'), not a true dietary supplement or herb. It carries serious health risks including liver damage and hormonal disruption, is banned in sports, and is not approved or recommended for use. We strongly advise against taking it.

Synthetic anabolic-androgenic steroid (not a plant) · Capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Dymethazine is a good idea for someone in your situation. Here is what our Dymethazine record says about it on its own.

Dymethazine: dosing

There is no established or recommended safe dose for Dymethazine, because it is not an approved medicine or a legitimate dietary supplement. We do not provide dosing for it.Because it is an anabolic steroid with real health risks, the safest amount is none.

From our Dymethazine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dymethazine monograph & all interactions
Medication

About Methazolamide

What Is Methazolamide Used For?

Brand name: Neptazane

Methazolamide tablets are used to treat eye conditions where lowering intraocular pressure (pressure inside the eye) is expected to help. These include chronic open-angle glaucoma and secondary glaucoma.

Methazolamide tablets are also used before surgery in acute angle-closure glaucoma, when reducing eye pressure ahead of the procedure is needed. Note that long-term use in angle-closure glaucoma is not appropriate.

Most-Reported Side Effects for Methazolamide

From FAERS, the FDA’s public side-effect reporting system (339 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 41 reports
Dizziness 29 reports
Dyspnea 28 reports
Headache 28 reports
Blood pressure increased 22 reports
See full Methazolamide drug information
Keep checking

Other Drugs & Dymethazine

Browse every other medication we’ve checked against Dymethazine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Dymethazine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Dymethazine list.

See the full Dymethazine interactions page
See every supplement checked against Methazolamide, ranked by severity
Evidence & sources

Dymethazine References

The 2 references that drive our Dymethazine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Agbenyefia P, Arnold CA, Kirkpatrick R 3rd. Cholestatic jaundice with the use of methylstenbolone and dymethazine, designer steroids found in super DMZ Rx 2.0 "Nutritional Supplement": A case report. J Investig Med High Impact Case Rep 2014;2(2):232470961 PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dymethazine and Methazolamide Together: Common Questions

Is it safe to take Dymethazine with Methazolamide?
We do not list a known interaction between Dymethazine and Methazolamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Dymethazine and Methazolamide have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Does Methazolamide interact with any supplements?
Yes. Methazolamide has documented interactions with 218 supplements in our database — Dymethazine is not one of them. The Methazolamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dymethazine monograph Uses, safety profile, and every drug interaction in one place Methazolamide drug information The full plain-English guide to this medication Methazolamide supplement interactions Every supplement checked against Methazolamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methazolamide and Dymethazine?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.