Eleuthero - Vraylar (Cariprazine Hydrochloride) Interaction
Herbal: Eleuthero
Also Known As: Eleutherococcus senticosus, Acanthopanax Obovatus, Ciwujia Root, Devil's Bush, Eleuthero Ginseng, Eleuthero Root, Eleutherococci Radix, Ginseng Siberiano, North Wu Jia Pi, Shigoka, Siberian Eleuthero, Siberian Ginseng, Eleuthero, Touch-Me-Not, Wild Pepper, Wu-jia
Drug: Cariprazine Hydrochloride
Brand names:
Vraylar
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 04, 2025
Interaction Details
Cariprazine Hydrochloride is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, eleuthero might increase levels of drugs metabolized by CYP3A4.
In vitro and animal research suggest that standardized extracts of eleuthero might inhibit CYP3A4. However, research in healthy human volunteers has found that taking eleuthero 485 mg twice daily for 14 days does not inhibit CYP3A4 drug metabolism.
Interaction Rating
Likelihood of Occurrence
UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
References
- Harkey MR, Henderson GL, Zhou L, et al. Effects of Siberian ginseng (Eleutherococcus senticosus) on c-DNA-expressed P450 drug metabolizing enzymes. Alt Ther 2001;7:S14.
- Donovan JL, DeVane CL, Chavin KD, et al. Siberian Ginseng (Eleutheroccus senticosus) Effects on CYP2D6 and CYP3A4 Activity in Normal Volunteers. Drug Metab Dispos 2003;31:519-22..
Eleuthero Overview
Eleuthero (Eleutherococcus senticosus) is a plant native to Asia and a member of the Araliaceae family. It is also commonly known as 'Siberian ginseng' or 'eleuthero root'. The root of the plant is used in traditional medicine for its purported ability to improve physical and mental performance, boost the immune system, and reduce fatigue. It is also claimed to have anti-inflammatory and antioxidant properties. Eleuthero is often referred to as an 'adaptogen'. Adaptogens are believed to help the body resist stress. It is important to note that although eleuthero is known as 'Siberian ginseng', it is not related to Panax ginseng.
Cariprazine Hydrochloride Overview
-
Cariprazine is used to treat schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions). Cariprazine is also used to treat episodes of depression in people with bipolar I disorder (manic depressive disorder; a disease that causes episodes of mania, episodes of depression and other abnormal moods). It is also used as a short term treatment for episodes of mania or mixed episodes (symptoms of mania and depression that happen together) in people with bipolar I disorder. Cariprazine is also used along with other medications to treat depressive symptoms in adults with major depressive disorder (MDD). Cariprazine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
Eleuthero - More Interactions
Eleuthero interacts with 1103 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
Ask A Pharmacist About Your Herbal Questions!
Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
Ask A Pharmacist