Drug & supplement interaction

Evodia + Granisetron

Granisetron brand names: Kytril, Sustol.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Evodia and Granisetron in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Granisetron states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Evodia and Granisetron

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Granisetron and Evodia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Evodia safety at a glance

Evodia overall Use caution Limited human safety data exist, so use carefully and under professional guidance.
Pregnancy Possibly Unsafe When used orally. Active constituents in evodia have uterine stimulant activity in animal models. Evodia might also decrease litter size in animal models. Theor... Read the full pregnancy detail
Breastfeeding Avoid There is not enough safety information, so it is best to avoid while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Granisetron and Evodia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Granisetron

Interactions in our licensed database are recorded against drug classes, not just single drug names. Granisetron is filed under 3 classifications — serotonergic drugs, serotonergic drugs, oral drugs. Evodia has documented interactions with 11 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), caffeine (moderate) and chlorzoxazone (parafon forte, paraflex) (moderate) — and none of Granisetron’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Evodia Does Interact With Other Medications

Evodia has 950 moderate known drug interactions in our database — Granisetron isn’t one of them. If you take anything else, check it against the full list below.

Moderate 950 No known interaction 1,880 (incl. Granisetron)
Taking anything else?

Check Another of Your Medications Against Evodia

Covers the 2,830 medications we’ve checked against Evodia. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Evodia and Granisetron May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An irregular heartbeat Worth acting on Additional detail

    Evodia

    “There is no reliable evidence regarding the safety of evodia from clinical trials. In animal studies, evodia has induced QT prolongation and Torsade de pointes.”

    Evodia · Natural Medicines adverse-effect record, reported in torsades de pointes.

    1 source cited
    1. 97035. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163. DOI

    “In animal studies, evodia acts as a proarrhythmic agent with a dose-dependent effect. Evodia infusion has resulted in QT prolongation and Torsade de pointes. It is not clear what dose of evodia, if any, is required to produce a similar effect in humans.”

    Evodia · Natural Medicines adverse-effect record, reported in torsades de pointes.

    1 source cited
    1. 97035. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163. DOI

    Granisetron

    Listed in the ADVERSE REACTIONS section of the FDA label for Granisetron. Read the label on DailyMed ›

Effects for Granisetron come from the ADVERSE REACTIONS section of its FDA label; effects for Evodia come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Evodia in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. Active constituents in evodia have uterine stimulant activity in animal models. Evodia might also decrease litter size in animal models. Theoretically, taking evodia during pregnancy might adversely affect pregnancy outcome.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Granisetron Products Have a Food Rule — Evodia Should Not Break It

At least one FDA label for a product containing Granisetron says to take it on an empty stomach. Most supplements — Evodia included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Granisetron on its own and move Evodia to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Granisetron products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Recommended Dosage ( 2.2 ): The recommended dosage in adults is 10 mg administered as a single subcutaneous injection at least 30 minutes before the start of emetogenic chemotherapy on Day 1.

From the Dosage and Administration section of the FDA label we read for Granisetron — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Granisetron

This page covers Evodia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Granisetron page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).

By severity: 2 major · 25 moderate · 11 minor.

From our pharmacist’s overview on the Granisetron page

“Granisetron (Kytril, Sustol) blocks serotonin signals to stop nausea from chemotherapy and surgery, and this is a list that warrants real caution before you add a supplement to it. Most of the entries raise serotonin themselves, and stacking them on a serotonin-acting drug can push toward serotonin syndrome, a dangerous overload of tha…”

Reviewed by 2 · Jul 18, 2026

Open the Granisetron interaction page

One more smart check

Taking Evodia as Part of a Dietary Supplement Product? Check It for Interactions

We hold 182 real supplement products containing Evodia, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Evodia. Even though Evodia itself has no known interaction with Granisetron, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Evodia and Granisetron Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Evodia
Top 25%

#345 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Granisetron
Steady interest

#2,161 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Evodia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Evodia and Granisetron records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Evodia

What is Evodia?

  • Digestive upset and nausea
  • Headaches
  • Menstrual cramps
  • Abdominal pain
  • Diarrhea

Evodia is a fruit used in traditional Chinese medicine, most often for digestive complaints, headaches, and menstrual pain. Human evidence for these uses is very limited, and it is mostly studied in laboratory and animal research. Talk with a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Tetradium ruticarpum · Rutaceae · Dried unripe fruit · Dried fruit, powder, capsules, tablets, teas, and traditional herbal formulas

An interaction check asks whether these two react with each other — it does not ask whether Evodia is a good idea for someone in your situation. Here is what our Evodia record says about it on its own.

Evodia: dosing

There is no well-established standard dose for evodia. Traditional use often relies on combination formulas prepared by trained practitioners, and modern supplement products vary widely in strength and ingredients.If you choose to use evodia, follow the directions on the product label and do not exceed the recommended amount.

From our Evodia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Evodia monograph & all interactions
Medication

About Granisetron

What Is Granisetron Used For?

Brand names: Kytril, Sustol

Granisetron is used to prevent nausea and vomiting linked to emetogenic (nausea-causing) cancer chemotherapy — including high-dose cisplatin — and radiation therapy, including total body irradiation and fractionated abdominal radiation. Granisetron hydrochloride tablets and Granisol oral solution are approved for both the chemotherapy and radiation indications. Sancuso skin patch is approved for prevention of nausea and vomiting in adults receiving moderately and/or highly emetogenic chemotherapy regimens of up to 5 consecutive days.

Granisetron hydrochloride injection (intravenous) is also used to prevent and treat postoperative nausea and vomiting in adults. Sustol (subcutaneous injection) is used in combination with other anti-nausea medicines in adults specifically for the prevention of acute and delayed nausea and vomiting associated with moderately emetogenic chemotherapy or anthracycline and cyclophosphamide combination chemotherapy regimens.

See full Granisetron drug information
Keep checking

Other Drugs & Evodia

Browse every other medication we’ve checked against Evodia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
950Moderate
0Minor
1,879No known interaction
950 Moderate 1,879 No interaction
Moderate

950 interactions

Showing 60 of 950 moderate interactions — see all 950 on the Evodia page.

No interaction 1,879 drugs checked — show the list

We also checked Evodia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,879 medications checked with no known interaction — see the full Evodia list.

See the full Evodia interactions page
See every supplement checked against Granisetron, ranked by severity
Evidence & sources

Evodia References

The 13 references that drive our Evodia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sheu JR, Kan YC, Hung WC, et al. The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C. Thromb Res 1998;92:53-64. PubMed
  2. Sheu JR, Hung WC, Lee YM, Yen MH. Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. Eur J Pharmacol 1996;318:469-75. PubMed
  3. Ueng YF, Tsai TH, Don MJ, et al. Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats. J Pharm Pharmacol 2005;57:227-32.
  4. King CL, Kong YC, Wong NS, et al. Uterotonic effect of Evodia rutaecarpa alkaloids. J Nat Prod 1980;43:577-82. PubMed
  5. Ueng YF, Jan WC, Lin LC, et al. The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes. Drug Metab Dispos 2002;30:349-53. PubMed
  6. Iwata H, Tezuka Y, Kadota S, et al. Mechanism-based inactivation of human liver microsomal CYP3A4 by rutaecarpine and limonin from Evodia fruit extract. Drug Metab Pharmacokinet 2005;20:34-45. PubMed
  7. Sheu JR, Hung WC, Wu CH, et al. Antithrombotic effect of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, on platelet plug formation in in vivo experiments. Br J Haematol 2000;110:110-5.
  8. Tsai TH, Chang CH, Lin LC. Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats. Planta Med 2005;71:640-5.
  9. Lee SK, Kim NH, Lee J, et al. Induction of cytochrome P450s by rutaecarpine and metabolism of rutaecarpine by cytochrome P450s. Planta Med 2004;70:753-7. PubMed
  10. Baburin I, Varkvisser R, Schramm A, et al. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo. Pharmacol Res. 2018 May;131:150-163. DOI
  11. Zhang W, Guo J, Wang D, et al. Effect of CYP3A inducer/inhibitor on pharmacokinetics of five alkaloids in Evodiae Fructus. Chem Biol Interact 2020;327:109146. PubMed
  12. Huang CJ, Huang WC, Lin WT, et al. Rutaecarpine, an alkaloid from Evodia rutaecarpa, can prevent platelet activation in humans and reduce microvascular thrombosis in mice: crucial role of the PI3K/Akt/GSK3ß signal axis through a cyclic nucleotides/VASP-in
  13. Bista SR, Lee SK, Thapa D, et al. Effects of oral rutaecarpine on the pharmacokinetics of intravenous chlorzoxazone in rats. Toxicol Res 2008;24(3):195-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Evodia and Granisetron Together: Common Questions

Is it safe to take Evodia with Granisetron?
We do not list a known interaction between Evodia and Granisetron. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Evodia and Granisetron have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Evodia and Granisetron at the same time of day?
At least one FDA label for a product containing Granisetron says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Granisetron on its own and move Evodia to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Evodia and Granisetron combination checked?
Interactions in our licensed database are recorded against drug classes. Granisetron is filed under 3 classifications, and Evodia has documented interactions with 11 drug classes — none of Granisetron's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Evodia interact with any other medications?
Yes. Evodia has 950 documented drug interactions in our database — Granisetron is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Granisetron interact with any supplements?
Yes. Granisetron has documented interactions with 38 supplements in our database — Evodia is not one of them. The Granisetron interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Evodia monograph Uses, safety profile, and every drug interaction in one place Granisetron drug information The full plain-English guide to this medication Granisetron supplement interactions Every supplement checked against Granisetron, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 13 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Granisetron and Evodia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.