Drug & supplement interaction

Flaxseed Oil + Prilocaine

Prilocaine brand name: Citanest Plain.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Flaxseed Oil and Prilocaine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Flaxseed Oil and Prilocaine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Prilocaine and Flaxseed Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Flaxseed Oil safety at a glance

Flaxseed Oil overall Use caution Generally well tolerated for most adults, but quality and dose vary by product.
Pregnancy Possibly Safe When used orally and appropriately for medicinal purposes, short-term. Although flaxseed oil has been used with apparent safety in clinical research in doses of... Read the full pregnancy detail
Breastfeeding Use caution Limited safety information during breastfeeding, so use only with medical advice.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Prilocaine and Flaxseed Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Prilocaine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Prilocaine is filed under a single classification — anesthesia. Flaxseed Oil has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and ezetimibe (zetia) (moderate) — and none of Prilocaine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Flaxseed Oil Does Interact With Other Medications

Flaxseed Oil has 293 moderate known drug interactions in our database — Prilocaine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 293 No known interaction 2,537 (incl. Prilocaine)
Taking anything else?

Check Another of Your Medications Against Flaxseed Oil

Covers the 2,830 medications we’ve checked against Flaxseed Oil. Pick one to open its full report.

What to actually watch for

What Flaxseed Oil Itself Has Been Linked To

This is not an interaction — nothing below involves Prilocaine. It is the side-effect record for Flaxseed Oil on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Flaxseed Oil, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction / An allergic reaction Worth acting on Additional detail

    “Orally, flaxseed oil is generally well tolerated. Topically, flaxseed oil seems to be well-tolerated.

    Most Common Adverse Effects:

    Topically: Itching, redness.

    Serious Adverse Effects (Rare):

    Orally: Severe allergic reactions such as anaphylaxis.”

    Flaxseed Oil · Natural Medicines adverse-effect record, reported in pruritus.

  • Dry mouth / Stomach upset / Diarrhea Additional detail

    “Orally, flaxseed oil may cause a change in bowel habits, dry mouth, and dyspepsia when taken at a dose of about 5 grams daily. However, these effects have been reported by only a small number of patients (approximately 3%). High doses of flaxseed oil (30 grams per day and higher) have been associated with loose stools and diarrhea.”

    Flaxseed Oil · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 16794. Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
    2. 5898. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
    3. 11025. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI
  • Itching Additional detail

    “Topically, eye drops containing flaxseed oil may cause redness and itching.”

    Flaxseed Oil · Natural Medicines adverse-effect record, reported in pruritus.

    1 source cited
    1. 101953. Downie LE, Hom MM, Berdy GJ, et al. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020;18(1):148-157. PubMed

Everything above comes from the Natural Medicines adverse-effect record for Flaxseed Oil — expand a row for the licensed statement it rests on. We haven’t matched Prilocaine to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Prilocaine.

Special populations

Flaxseed Oil in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally and appropriately for medicinal purposes, short-term. Although flaxseed oil has been used with apparent safety in clinical research in doses of 1-2 grams daily for up to 6 weeks, some population research has found that consuming flaxseed oil during the second and third trimesters of pregnancy is associated with a four-fold increased risk of premature birth.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Prilocaine

This page covers Flaxseed Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prilocaine page lists 5 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (major), Cannabis (moderate), Cowhage (moderate), Datura Wrightii (moderate) and Delta-9-tetrahydrocannabinol (thc) (moderate).

By severity: 1 major · 4 moderate.

From our pharmacist’s overview on the Prilocaine page

“Prilocaine (Citanest Plain) is the numbing medicine injected for dental work and minor procedures, and every one of the five supplement ingredients on this list earns real caution, because each can change how the body handles anesthesia itself. Fever bark is the single entry rated major.”

Reviewed by 2 · Jul 18, 2026

Open the Prilocaine interaction page

One more smart check

Taking Flaxseed Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,329 real supplement products containing Flaxseed Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Flaxseed Oil. Even though Flaxseed Oil itself has no known interaction with Prilocaine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Flaxseed Oil and Prilocaine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Flaxseed Oil
Top 25%

#183 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Prilocaine
Steady interest

#1,772 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Flaxseed Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Flaxseed Oil and Prilocaine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Flaxseed Oil

What is Flaxseed Oil?

  • Source of omega-3 (ALA) fatty acids
  • Heart and cholesterol health
  • Dry skin and inflammation
  • Constipation
  • General wellness

Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy fats, but evidence for most specific health claims is limited or mixed. It is generally well tolerated, but talk to your pharmacist or doctor before starting, especially if you are pregnant or have a bleeding risk.

Linum usitatissimum · Linaceae · Oil pressed from the seeds · Liquid oil, softgel capsules, salad oil

An interaction check asks whether these two react with each other — it does not ask whether Flaxseed Oil is a good idea for someone in your situation. Here is what our Flaxseed Oil record says about it on its own.

Flaxseed Oil: dosing

There is no official standardized dose of flaxseed oil for any health condition. Products vary widely in strength and in how much ALA they provide per serving.The safest approach is to follow the dose printed on the product label and not exceed it without medical advice. To keep the oil fresh, store it as directed (often refrigerated) and avoid using it for cooking at high heat.

From our Flaxseed Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Flaxseed Oil monograph & all interactions
Medication

About Prilocaine

Most-Reported Side Effects for Prilocaine

From FAERS, the FDA’s public side-effect reporting system (1,840 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 188 reports
Nausea 153 reports
Diarrhea 125 reports
Vomiting 96 reports
Dyspnea 92 reports
Keep checking

Other Drugs & Flaxseed Oil

Browse every other medication we’ve checked against Flaxseed Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
293Moderate
0Minor
2,536No known interaction
293 Moderate 2,536 No interaction
Moderate

293 interactions

Showing 60 of 293 moderate interactions — see all 293 on the Flaxseed Oil page.

No interaction 2,536 drugs checked — show the list

We also checked Flaxseed Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,536 medications checked with no known interaction — see the full Flaxseed Oil list.

See the full Flaxseed Oil interactions page
See every supplement checked against Prilocaine, ranked by severity
Evidence & sources

Flaxseed Oil References

The 21 references that drive our Flaxseed Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
  2. Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
  3. Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
  4. De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
  5. Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
  6. Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI
  7. Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
  8. Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
  9. Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. PubMed
  10. Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
  11. University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
  12. Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
  13. Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
  14. Taghizadeh M, Jamilian M, Mazloomi M, Sanami M, Asemi Z. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids on vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. J
  15. Blackwood DP, LaVallee RK, Al Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Flaxseed Oil and Prilocaine Together: Common Questions

Is it safe to take Flaxseed Oil with Prilocaine?
We do not list a known interaction between Flaxseed Oil and Prilocaine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Flaxseed Oil and Prilocaine combination checked?
Interactions in our licensed database are recorded against drug classes. Prilocaine is filed under 1 classification, and Flaxseed Oil has documented interactions with 3 drug classes — none of Prilocaine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Flaxseed Oil interact with any other medications?
Yes. Flaxseed Oil has 293 documented drug interactions in our database — Prilocaine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Prilocaine interact with any supplements?
Yes. Prilocaine has documented interactions with 5 supplements in our database — Flaxseed Oil is not one of them. The Prilocaine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Flaxseed Oil monograph Uses, safety profile, and every drug interaction in one place Prilocaine supplement interactions Every supplement checked against Prilocaine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Prilocaine and Flaxseed Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.