Drug & supplement interaction

Gamboge + Pegloticase

Pegloticase brand name: Krystexxa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Gamboge and Pegloticase in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Gamboge and Pegloticase

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pegloticase and Gamboge in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Gamboge safety at a glance

Gamboge overall Avoid Gamboge resin is a harsh purgative and can be toxic when swallowed.
Pregnancy Possibly Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pegloticase and Gamboge? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pegloticase

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pegloticase is filed under a single classification — antigout drugs. Gamboge has documented interactions with 5 drug classes — the most serious being corticosteroids (moderate), digoxin (lanoxin) (moderate) and diuretic drugs (moderate) — and none of Pegloticase’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Gamboge Does Interact With Other Medications

Gamboge has 122 moderate known drug interactions in our database — Pegloticase isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Pegloticase)
Taking anything else?

Check Another of Your Medications Against Gamboge

Covers the 2,830 medications we’ve checked against Gamboge. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Gamboge and Pegloticase May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Vomiting Additional detail

    Gamboge

    “Orally, abdominal pain and vomiting have been reported with gamboge at doses as low as 200 mg. Deaths have been reported after ingestion of 4 grams of gamboge (18).”

    Gamboge · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, abdominal pain and vomiting have been reported with gamboge at doses as low as 200 mg (18).”

    Gamboge · Natural Medicines adverse-effect record, reported in myasthenia gravis.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Pegloticase

    Listed in the ADVERSE REACTIONS section of the FDA label for Pegloticase. Read the label on DailyMed ›

Reported for Gamboge but not commonly for Pegloticase: stomach pain.

Effects for Pegloticase come from the ADVERSE REACTIONS section of its FDA label; effects for Gamboge come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 3,424 voluntary FDA FAERS reports for Pegloticase that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Gamboge in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Pegloticase

This page covers Gamboge only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pegloticase page lists 1 supplement it has a documented interaction with, worst first, each one explained.

The most serious there right now: Inosine (moderate).

By severity: 1 moderate.

From our pharmacist’s overview on the Pegloticase page

“Inosine is the one supplement on record that can work against pegloticase (Krystexxa), the IV enzyme infused for severe gout that has stopped responding to standard treatment. Inosine raises uric acid in the blood and urine, which is precisely what pegloticase exists to lower, so combining the two could blunt the very benefit those inf…”

Reviewed by 2 · Jul 18, 2026

Open the Pegloticase interaction page

How much people look this up

Where Gamboge and Pegloticase Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gamboge
Steady interest

#901 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pegloticase
Steady interest

#2,387 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Gamboge reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Gamboge and Pegloticase records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Gamboge

What is Gamboge?

  • Laxative (purgative)
  • Expelling intestinal worms
  • Traditional wound care
  • Use as a yellow dye/pigment

Gamboge is a bright yellow tree resin used historically as a strong laxative and as an artists' pigment, but it is toxic in even modest amounts and is not a safe dietary supplement. Modern interest centers on its compound gambogic acid in laboratory cancer research, which does not make the raw resin safe to take. We recommend avoiding oral use of gamboge.

Garcinia hanburyi · Clusiaceae · Dried resin (gum-resin) from the bark/latex · Resin powder, traditional pills, paint pigment (not a typical modern supplement)

An interaction check asks whether these two react with each other — it does not ask whether Gamboge is a good idea for someone in your situation. Here is what our Gamboge record says about it on its own.

Gamboge: dosing

There is no established safe dose of gamboge for any health use, and we do not provide one. Because the resin is considered toxic and is not a recognized supplement, there are no reliable, standardized products with proven dosing.If you ever encounter a product that contains gamboge, do not take it without first talking to a pharmacist or doctor. In general, our recommendation is to avoid oral use entirely and choose safer, well-studied options for problems like constipation.

From our Gamboge monograph — the full record covers uses, side effects and every documented interaction.

Read the full Gamboge monograph & all interactions
Medication

About Pegloticase Injection

What Is Pegloticase Injection Used For?

Brand name: Krystexxa

Krystexxa is used to treat chronic gout in adults whose gout has not responded to conventional treatments — either because standard uric-acid-lowering medications (like xanthine oxidase inhibitors) haven't brought uric acid to a normal level, or because those drugs cannot be used.

Krystexxa is not recommended for people who have high uric acid levels but no gout symptoms (a condition called asymptomatic hyperuricemia).

Most-Reported Side Effects for Pegloticase

From FAERS, the FDA’s public side-effect reporting system (3,686 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Gout 562 reports
Blood uric acid increased 405 reports
Infusion related reaction 365 reports
Therapeutic response decreased 240 reports
Dyspnea 180 reports
See full Pegloticase Injection drug information
Keep checking

Other Drugs & Gamboge

Browse every other medication we’ve checked against Gamboge — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Gamboge page.

No interaction 2,707 drugs checked — show the list

We also checked Gamboge against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Gamboge list.

See the full Gamboge interactions page
See every supplement checked against Pegloticase, ranked by severity
Evidence & sources

Gamboge References

The 2 references that drive our Gamboge monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Gamboge and Pegloticase Together: Common Questions

Is it safe to take Gamboge with Pegloticase?
We do not list a known interaction between Gamboge and Pegloticase. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Gamboge and Pegloticase have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Gamboge and Pegloticase combination checked?
Interactions in our licensed database are recorded against drug classes. Pegloticase is filed under 1 classification, and Gamboge has documented interactions with 5 drug classes — none of Pegloticase's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Gamboge interact with any other medications?
Yes. Gamboge has 122 documented drug interactions in our database — Pegloticase is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pegloticase interact with any supplements?
Yes. Pegloticase has documented interactions with 1 supplement in our database — Gamboge is not one of them. The Pegloticase interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Gamboge monograph Uses, safety profile, and every drug interaction in one place Pegloticase Injection drug information The full plain-English guide to this medication Pegloticase supplement interactions Every supplement checked against Pegloticase, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pegloticase and Gamboge?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.