Drug & supplement interaction

Garden Cress + Fenoprofen Calcium

Fenoprofen Calcium brand name: Nalfon.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Garden Cress and Fenoprofen Calcium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Fenoprofen Calcium states a food rule worth keeping to.

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Interaction report

Garden Cress and Fenoprofen Calcium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Fenoprofen Calcium and Garden Cress in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Garden Cress safety at a glance

Garden Cress overall Use caution Generally safe as a food, but concentrated seed amounts have limited safety data.
Pregnancy Avoid Seeds are traditionally believed to stimulate the uterus, so avoid medicinal amounts during pregnancy.
Breastfeeding Use caution Food amounts are likely fine, but safety of concentrated supplements is not well studied.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Fenoprofen Calcium and Garden Cress? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Fenoprofen Calcium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Fenoprofen Calcium is filed under 5 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates. Garden Cress has documented interactions with 14 drug classes — the most serious being amlodipine (norvasc) (moderate), anticoagulant/antiplatelet drugs (moderate) and antidiabetes drugs (moderate) — and none of Fenoprofen Calcium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Garden Cress Does Interact With Other Medications

Garden Cress has 398 moderate known drug interactions in our database — Fenoprofen Calcium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 398 No known interaction 2,432 (incl. Fenoprofen Calcium)
Taking anything else?

Check Another of Your Medications Against Garden Cress

Covers the 2,830 medications we’ve checked against Garden Cress. Pick one to open its full report.

What to actually watch for

What Fenoprofen Calcium’s Own FDA Label Lists

This is not an interaction — none of it involves Garden Cress. These are the most notable effects listed in the ADVERSE REACTIONS section of Fenoprofen Calcium’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • Heart failure Worth acting on
  • Confusion Worth acting on
  • Kidney problems Worth acting on
  • Raised blood pressure Worth acting on
  • Shortness of breath Worth acting on
  • Liver problems Worth acting on
  • Bleeding or bruising Worth acting on
  • A higher chance of infection Worth acting on

Showing the 10 most notable of 30 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Fenoprofen Calcium. Read the label on DailyMed › Where a percentage is shown, it is the share of 49 voluntary FDA FAERS reports for Fenoprofen Calcium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Garden Cress’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Garden Cress side to compare — that is a limit of the record, not a statement that Garden Cress has no side effects.

How to take them

Some Fenoprofen Calcium Products Have a Food Rule — Garden Cress Should Not Break It

At least one FDA label for a product containing Fenoprofen Calcium says to take it with food. If you take Garden Cress on an empty stomach out of habit, keep them separate — and take Fenoprofen Calcium with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Fenoprofen Calcium products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Fenoprofen Calcium may be administered with meals or with milk.

From the Dosage and Administration section of the FDA label we read for Fenoprofen Calcium — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Fenoprofen Calcium

This page covers Garden Cress only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fenoprofen Calcium page lists 32 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 16 moderate · 11 minor.

From our pharmacist’s overview on the Fenoprofen Calcium page

“The kidneys and the stomach lining take the brunt of any NSAID, and fenoprofen calcium (Nalfon), prescribed for arthritis and other pain, is no exception. This list of 32 interacting supplements deserves real caution; five carry a major rating, and understanding those five comes first.”

Reviewed by 2 · Jul 18, 2026

Open the Fenoprofen Calcium interaction page

One more smart check

Taking Garden Cress as Part of a Dietary Supplement Product? Check It for Interactions

We hold 16 real supplement products containing Garden Cress, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Garden Cress. Even though Garden Cress itself has no known interaction with Fenoprofen Calcium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Garden Cress and Fenoprofen Calcium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Garden Cress
Top half

#672 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fenoprofen Calcium
Steady interest

#1,919 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Garden Cress reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Garden Cress and Fenoprofen Calcium records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Garden Cress

What is Garden Cress?

Garden Cress
  • Digestive support
  • Bone health
  • Iron and vitamin source
  • Cough and respiratory comfort
  • Boosting breast milk (traditional)
  • Constipation relief

Garden cress is a nutritious leafy herb and seed used widely in cooking and traditional medicine, providing vitamins, minerals, and fiber. While it has a long history of use for digestion, bone health, and lactation, strong human research supporting most medicinal claims is limited. It is generally safe as a food, but concentrated seed supplements should be used cautiously and avoided in pregnancy.

Lepidium sativum · Brassicaceae · Seeds and leaves · Fresh leaves, seeds, seed powder, sprouts

An interaction check asks whether these two react with each other — it does not ask whether Garden Cress is a good idea for someone in your situation. Here is what our Garden Cress record says about it on its own.

Garden Cress: dosing

There is no official, standardized medicinal dose for garden cress. It is most often consumed as a food—fresh leaves, sprouts, or soaked seeds added to meals or drinks.If you use a seed powder or supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Garden Cress monograph — the full record covers uses, side effects and every documented interaction.

Read the full Garden Cress monograph & all interactions
Medication

About Fenoprofen

What Is Fenoprofen Used For?

Brand name: Nalfon

Fenoprofen is used to relieve mild to moderate pain in adults. It is also used to reduce the pain, swelling, and stiffness caused by rheumatoid arthritis and osteoarthritis.

These uses are supported by products including Fenoprofen Calcium, Fenopron, and Nalfon capsules. Nalfon is also available as a tablet.

Most-Reported Side Effects for Fenoprofen Calcium

From FAERS, the FDA’s public side-effect reporting system (49 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 5 reports
Drug hypersensitivity 5 reports
Headache 5 reports
Myocardial infarction 4 reports
Pain in extremity 4 reports
See full Fenoprofen drug information
Keep checking

Other Drugs & Garden Cress

Browse every other medication we’ve checked against Garden Cress — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
398Moderate
0Minor
2,431No known interaction
398 Moderate 2,431 No interaction
Moderate

398 interactions

Showing 60 of 398 moderate interactions — see all 398 on the Garden Cress page.

No interaction 2,431 drugs checked — show the list

We also checked Garden Cress against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,431 medications checked with no known interaction — see the full Garden Cress list.

See the full Garden Cress interactions page
See every supplement checked against Fenoprofen Calcium, ranked by severity
Evidence & sources

Garden Cress References

The 12 references that drive our Garden Cress monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Eddouks, M. and Maghrani, M. Effect of Lepidium sativum L. on renal glucose reabsorption and urinary TGF-beta 1 levels in diabetic rats. Phytother.Res 2008;22(1):1-5.
  2. Maghrani, M, Zeggwagh, NA, Michel, JB, and Eddouks, M. Antihypertensive effect of <it>Lepidium sativum</it> L. in spontaneously hypertensive rats. Journal of Ethnopharmacology (Ireland) 2005;100:193-197.
  3. Al-Jenoobi FI, Ahad A, Mahrous GM, Al-Mohizea AM, AlKharfy KM, Al-Suwayeh SA. Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs. Pharm Biol 2015;53(2):296-300. PubMed
  4. Alkharfy KM, Al-Jenoobi FI, Alam MA, et al. Lepidium sativum but not Nigella sativa affects carbamazepine disposition in an animal model. Drug Metab Lett 2013;7:47-51. PubMed
  5. Chen X, Yuan H, Shi F, Zhu Y. Effect of garden cress in reducing blood glucose, improving blood lipids, and reducing oxidative stress in a mouse model of diabetes induced by a high-fat diet and streptozotocin. J Sci Food Agric 2020;100(5):2074-2081. PubMed
  6. Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
  7. Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
  8. Ramadan S, Hegab AM, Al-Awthan YS, Al-Duais MA, Tayel AA, Al-Saman MA. Comparison of the efficiency of Lepidium sativum, Ficus carica, and Punica granatum methanolic extracts in relieving hyperglycemia and hyperlipidemia of streptozotocin-induced diabetic
  9. I Al-Suwaydani A, Alam MA, Raish M, A Bin Jardan Y, Ahad A, I Al-Jenoobi F. Effect of C. cyminum and L. sativum on pharmacokinetics and pharmacodynamics of antidiabetic drug gliclazide. Curr Drug Metab 2022;23(10):842-849.
  10. Alam MA, Bin Jardan YA, Raish M, Al-Mohizea AM, Ahad A, Al-Jenoobi FI. Herb-drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa. Xenobiotica 2022;52(2):177
  11. Ahad A, Raish M, Abdelrahman IA, et al. Changes in pharmacokinetics and pharmacodynamics of losartan in experimental diseased rats treated with Curcuma longa and Lepidium sativum. Pharmaceuticals (Basel) 2022;16(1):33. PubMed
  12. Doghmane A, Aouacheri O, Laouaichia R, Saka S. The investigation of the efficacy ratio of cress seeds supplementation to moderate hyperglycemia and hepatotoxicity in streptozotocin-induced diabetic rats. J Diabetes Metab Disord 2021;20(1):447-459. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Garden Cress and Fenoprofen Calcium Together: Common Questions

Is it safe to take Garden Cress with Fenoprofen Calcium?
We do not list a known interaction between Garden Cress and Fenoprofen Calcium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Garden Cress and Fenoprofen Calcium at the same time of day?
At least one FDA label for a product containing Fenoprofen Calcium says to take it with food. If you take Garden Cress on an empty stomach out of habit, keep them separate and take Fenoprofen Calcium with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Fenoprofen Calcium products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Garden Cress and Fenoprofen Calcium combination checked?
Interactions in our licensed database are recorded against drug classes. Fenoprofen Calcium is filed under 5 classifications, and Garden Cress has documented interactions with 14 drug classes — none of Fenoprofen Calcium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Garden Cress interact with any other medications?
Yes. Garden Cress has 398 documented drug interactions in our database — Fenoprofen Calcium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Fenoprofen Calcium interact with any supplements?
Yes. Fenoprofen Calcium has documented interactions with 32 supplements in our database — Garden Cress is not one of them. The Fenoprofen Calcium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Garden Cress monograph Uses, safety profile, and every drug interaction in one place Fenoprofen drug information The full plain-English guide to this medication Fenoprofen Calcium supplement interactions Every supplement checked against Fenoprofen Calcium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Fenoprofen Calcium and Garden Cress?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.