Drug & supplement interaction

Gotu Kola + Flibanserin

Flibanserin brand name: Addyi.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Gotu Kola has a moderate interaction with Flibanserin. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Gotu Kola and Flibanserin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Flibanserin

Flibanserin falls under CNS DEPRESSANTS — the group Gotu Kola interacts with.

Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.
In vitro research suggests that gotu kola may have sedative effects via binding of GABA receptors.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version: Addyi (flibanserin) already tends to make people drowsy, and it can lower your blood pressure or cause dizziness and fainting, especially if you stand up quickly. Gotu kola may have its own mild calming effect, possibly by acting on GABA, the brain's slow-down signal. Put the two together and you could feel sleepier or more lightheaded than you'd expect.

I want to be honest about the strength of this: it's theoretical, based mostly on lab research, not real patient reports. So it isn't a guaranteed problem. Still, since flibanserin's sedation can be significant on its own, it's worth a quick chat with your pharmacist or doctor before adding gotu kola, rather than changing anything on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the east Asian medical plant Centella asiatica. Phytomedicine 2000;7:427-48.
  2. Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol 2000;20:680-4. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Gotu Kola Also Interacts With Other Medications

Gotu Kola has 578 moderate known drug interactions in our database — the Flibanserin one above is one of them. If you take anything else, check it against the full list below.

Moderate 578 No known interaction 2,252 (incl. Flibanserin)
Taking anything else?

Check Another of Your Medications Against Gotu Kola

Covers the 2,830 medications we’ve checked against Gotu Kola. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Flibanserin

This page covers Gotu Kola only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Flibanserin page lists 199 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Grapefruit (major).

By severity: 9 major · 151 moderate · 39 minor.

From our pharmacist’s overview on the Flibanserin page

“Flibanserin (Addyi) is a nightly pill for low sexual desire in premenopausal women, and because it is sedating and can lower blood pressure, its supplement list deserves genuine care; nine of the 199 entries rate major, and those are the ones to learn first. Seventy-eight ingredients have calming effects that stack with flibanserin's d…”

Reviewed by 2 · Jul 18, 2026

Open the Flibanserin interaction page

One more smart check

Taking Gotu Kola as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,832 real supplement products containing Gotu Kola, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Gotu Kola. Your product may carry other ingredients that interact with Flibanserin too, on top of Gotu Kola — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Gotu Kola and Flibanserin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Gotu Kola
Top 10%

#144 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Flibanserin
Top half

#955 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Gotu Kola

What is Gotu Kola?

Gotu Kola
  • Wound healing
  • Varicose veins and poor circulation
  • Anxiety and stress
  • Memory and mental clarity
  • Skin health and scarring

Gotu kola is a traditional Ayurvedic and Asian herb that people use for wound healing, circulation, skin problems, and as a calming or memory-supporting herb. Some early studies suggest possible benefits for vein health and skin, but the overall evidence is limited and not strong. Talk to your pharmacist or doctor before using it, especially if you are pregnant, breastfeeding, or have liver problems.

Read the full Gotu Kola monograph & all interactions
Medication

About Flibanserin

What Is Flibanserin Used For?

Brand name: Addyi

Addyi is approved to treat acquired, generalized hypoactive sexual desire disorder (HSDD) — a condition where low sexual desire causes significant distress or relationship difficulty — in women under 65. "Acquired" means the low desire developed after a period of normal desire; "generalized" means it happens regardless of the situation or partner.

Addyi is not intended for use in men, and it is not a sexual performance enhancer. It is also not meant for HSDD that is caused by a medical condition, a psychiatric condition, relationship problems, or another medication.

See full Flibanserin drug information
Keep checking

Other Drugs & Gotu Kola

Browse every other medication we’ve checked against Gotu Kola — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
578Moderate
0Minor
2,251No known interaction
578 Moderate 2,251 No interaction
Moderate

578 interactions

Showing 60 of 578 moderate interactions — see all 578 on the Gotu Kola page.

No interaction 2,251 drugs checked — show the list

We also checked Gotu Kola against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,251 medications checked with no known interaction — see the full Gotu Kola list.

See the full Gotu Kola interactions page
See every supplement checked against Flibanserin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Gotu Kola monograph › Uses, safety, and every drug interaction in one place Flibanserin supplement interactions › Every supplement checked against Flibanserin, ranked by severity Flibanserin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Gotu Kola and Flibanserin Together: Common Questions

Can you take Gotu Kola with Flibanserin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Gotu Kola and Flibanserin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Flibanserin and Gotu Kola?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.