Drug & supplement interaction

Mace + Metformin, Sitagliptin

Metformin, Sitagliptin brand names: Janumet, Janumet XR.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Mace and Metformin, Sitagliptin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Metformin, Sitagliptin states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Mace and Metformin, Sitagliptin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metformin, Sitagliptin and Mace in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Mace safety at a glance

Mace overall Use caution Safe as a culinary spice but large or concentrated doses can be toxic.
Pregnancy Possibly Unsafe When used orally in medicinal amounts. Mace might have abortifacient activity, and its safrole content might be mutagenic. Read the full pregnancy detail
Breastfeeding Use caution Food amounts are probably fine, but avoid concentrated supplements due to lack of safety data.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metformin, Sitagliptin and Mace? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metformin, Sitagliptin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metformin, Sitagliptin is filed under 5 classifications — including organic cation transporter 2 (oct2) substrates, antidiabetes drugs, oral drugs. Mace has documented interactions with 4 drug classes — the most serious being cns depressants (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and immunosuppressants (moderate) — and none of Metformin, Sitagliptin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Mace Does Interact With Other Medications

Mace has 500 moderate known drug interactions in our database — Metformin, Sitagliptin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 500 No known interaction 2,330 (incl. Metformin, Sitagliptin)
Taking anything else?

Check Another of Your Medications Against Mace

Covers the 2,830 medications we’ve checked against Mace. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Mace and Metformin, Sitagliptin May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Seizures Worth acting on Additional detail

    Mace

    “There are no reports of adverse neurologic or central nervous system (CNS)-related events due to ingestion of mace. However, mace contains myristicin, which is structurally similar to certain hallucinogenic chemicals. High intake of nutmeg, a similar herb, has been reported to cause headache, dizziness, drowsiness, hot and cold sensations, sensations of limb loss, convulsions, and coma.”

    Mace · Natural Medicines adverse-effect record, reported in cluster headache.

    4 sources cited
    1. 2563. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
    2. 19294. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
    3. 19300. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
    4. 19487. Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed

    Metformin, Sitagliptin

    Listed in the ADVERSE REACTIONS section of the FDA label for Metformin, Sitagliptin. Read the label on DailyMed ›

  • A skin rash Additional detail

    Mace

    “Orally, mace seems to be well tolerated when consumed in appropriate amounts. No adverse effects have been reported, although a thorough evaluation of safety outcomes has not been conducted. However, severe cardiovascular, gastrointestinal, neurologic, ocular, and psychiatric adverse events have been reported following high intake of the related herb nutmeg.”

    Mace · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 19293. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
    2. 19492. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
    3. 39898. Dooms-Goossens, A., Dubelloy, R., and Degreef, H. Contact and systemic contact-type dermatitis to spices. Dermatol Clin 1990;8(1):89-93. DOI

    “Topically, contact and systemic contact-type dermatitis to mace has occurred in rare cases.”

    Mace · Natural Medicines adverse-effect record, reported in dermatitis.

    1 source cited
    1. 39898. Dooms-Goossens, A., Dubelloy, R., and Degreef, H. Contact and systemic contact-type dermatitis to spices. Dermatol Clin 1990;8(1):89-93. DOI

    Metformin, Sitagliptin

    Listed in the ADVERSE REACTIONS section of the FDA label for Metformin, Sitagliptin. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Mace

    “There are no reports of adverse gastrointestinal events due to ingestion of mace. However, mace contains myristicin, which is structurally similar to certain hallucinogenic chemicals. High intake of nutmeg, a similar spice, has been reported to cause nausea and vomiting, epigastric pain, and gastroenteritis. Theoretically, high intake of mace may have similar effects.”

    Mace · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    3 sources cited
    1. 2563. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
    2. 19294. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
    3. 19300. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed

    Metformin, Sitagliptin

    Listed in the ADVERSE REACTIONS section of the FDA label for Metformin, Sitagliptin. Read the label on DailyMed ›

  • Headache Additional detail

    Mace

    Recorded for Mace in the same Natural Medicines adverse-effect record shown under Seizures above.

    Metformin, Sitagliptin

    Listed in the ADVERSE REACTIONS section of the FDA label for Metformin, Sitagliptin. Read the label on DailyMed ›

Reported for Mace but not commonly for Metformin, Sitagliptin: hallucinations, confusion, anxiety or restlessness and a fast or pounding heartbeat.

Effects for Metformin, Sitagliptin come from the ADVERSE REACTIONS section of its FDA label; effects for Mace come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Mace in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally in medicinal amounts. Mace might have abortifacient activity, and its safrole content might be mutagenic.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Metformin, Sitagliptin Products Have a Food Rule — Mace Should Not Break It

At least one FDA label for a product containing Metformin, Sitagliptin says to take it with food. If you take Mace on an empty stomach out of habit, keep them separate — and take Metformin, Sitagliptin with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Metformin, Sitagliptin products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Take sitagliptin and metformin hydrochloride extended-release tablets orally once daily with a meal.

From the Dosage and Administration section of the FDA label we read for Metformin, Sitagliptin — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Metformin, Sitagliptin

This page covers Mace only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metformin, Sitagliptin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 217 moderate · 38 minor.

From our pharmacist’s overview on the Metformin, Sitagliptin page

“Many people prescribed metformin with sitagliptin (Janumet, Janumet XR) for type 2 diabetes also try herbs sold as blood sugar support, fenugreek among the most popular, and that habit is exactly where the risk on this page concentrates. Of 257 documented supplement interactions, 239 can push glucose in the same direction the medicatio…”

Reviewed by 2 · Jul 18, 2026

Open the Metformin, Sitagliptin interaction page

One more smart check

Taking Mace as Part of a Dietary Supplement Product? Check It for Interactions

We hold 38 real supplement products containing Mace, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Mace. Even though Mace itself has no known interaction with Metformin, Sitagliptin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Mace and Metformin, Sitagliptin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Mace
Top half

#464 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metformin, Sitagliptin
Steady interest

#1,424 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Mace reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Mace and Metformin, Sitagliptin records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Mace

What is Mace?

  • Digestive upset and gas
  • Flavoring and culinary spice
  • Nausea
  • Appetite stimulation
  • Traditional pain or muscle relief

Mace is the lacy red covering of the nutmeg seed and comes from the same tree as nutmeg. It is mostly used as a cooking spice and in traditional medicine for digestion, but there is little solid human research to support its health uses. In normal food amounts it is generally safe, but large doses can be toxic, so use it as a spice and check with your pharmacist before taking concentrated supplements.

Myristica fragrans · Myristicaceae · The dried red, lacy covering (aril) of the nutmeg seed · Whole dried blades, ground powder, essential oil, capsules

An interaction check asks whether these two react with each other — it does not ask whether Mace is a good idea for someone in your situation. Here is what our Mace record says about it on its own.

Mace: dosing

There is no established standardized medicinal dose for mace. As a spice, the amount used in cooking is small and considered safe.If you choose to use a mace supplement, follow the directions on the product label and do not exceed them. Because high amounts can be toxic, more is not better.

From our Mace monograph — the full record covers uses, side effects and every documented interaction.

Read the full Mace monograph & all interactions
Keep checking

Other Drugs & Mace

Browse every other medication we’ve checked against Mace — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
500Moderate
0Minor
2,329No known interaction
500 Moderate 2,329 No interaction
Moderate

500 interactions

Showing 60 of 500 moderate interactions — see all 500 on the Mace page.

No interaction 2,329 drugs checked — show the list

We also checked Mace against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,329 medications checked with no known interaction — see the full Mace list.

See the full Mace interactions page
See every supplement checked against Metformin, Sitagliptin, ranked by severity
Evidence & sources

Mace References

The 18 references that drive our Mace monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. PubMed
  3. Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. DOI
  4. Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. PubMed
  5. McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. PubMed
  6. Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. PubMed
  7. Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. PubMed
  8. Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. PubMed
  9. Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. PubMed
  10. Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. PubMed
  11. Checker R, Chatterjee S, Sharma D, et al. Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol. 2008;8(5):661-669. PubMed
  12. Sell AB, Carlini EA. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology. 1976;14(4):367-77. PubMed
  13. Fundarò A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375-80.
  14. Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. PubMed
  15. Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Mace and Metformin, Sitagliptin Together: Common Questions

Is it safe to take Mace with Metformin, Sitagliptin?
We do not list a known interaction between Mace and Metformin, Sitagliptin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Mace and Metformin, Sitagliptin have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Mace and Metformin, Sitagliptin at the same time of day?
At least one FDA label for a product containing Metformin, Sitagliptin says to take it with food. If you take Mace on an empty stomach out of habit, keep them separate and take Metformin, Sitagliptin with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Metformin, Sitagliptin products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Mace and Metformin, Sitagliptin combination checked?
Interactions in our licensed database are recorded against drug classes. Metformin, Sitagliptin is filed under 5 classifications, and Mace has documented interactions with 4 drug classes — none of Metformin, Sitagliptin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Mace interact with any other medications?
Yes. Mace has 500 documented drug interactions in our database — Metformin, Sitagliptin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metformin, Sitagliptin interact with any supplements?
Yes. Metformin, Sitagliptin has documented interactions with 257 supplements in our database — Mace is not one of them. The Metformin, Sitagliptin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Mace monograph Uses, safety profile, and every drug interaction in one place Metformin, Sitagliptin supplement interactions Every supplement checked against Metformin, Sitagliptin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 18 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metformin, Sitagliptin and Mace?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.