Medication interaction hub

What Supplements Interact with Metformin, Sitagliptin?

Metformin, Sitagliptin brand names: Janumet, Janumet XR. Every interaction below applies to the brands too.

257 Interactions 2 Major 217 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Metformin, Sitagliptin? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Metformin, Sitagliptin against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Many people prescribed metformin with sitagliptin (Janumet, Janumet XR) for type 2 diabetes also try herbs sold as blood sugar support, fenugreek among the most popular, and that habit is exactly where the risk on this page concentrates. Of 257 documented supplement interactions, 239 can push glucose in the same direction the medication already does, sometimes hard enough to cause genuine hypoglycemia, so this is a list I would weigh carefully rather than casually. The two major-rated entries come first: Siberian cocklebur has caused severe low blood sugar in humans, and activated charcoal can pull the drug from your system before it works.

Most of the 217 moderate entries repeat that additive glucose theme, with another 38 rated minor, which makes closer blood sugar checks the right response whenever a supplement joins the regimen. A handful of bulky fibers act differently, slowing absorption of oral doses and quietly weakening them. Space those well apart from each dose, and skip the two majors outright.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 217 Minor 38 No known interaction 1,195

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Metformin, Sitagliptin: Top Interactions at a Glance

The Metformin, Sitagliptin supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 257 interacting ingredients — plus 1,195 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Metformin, Sitagliptin Combinations Today

The Metformin, Sitagliptin + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Clove + Metformin, Sitagliptini

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Minor Likelihood Possible Yerba Mate + Metformin, Sitagliptini

Theoretically, metformin might increase the levels and adverse effects of the caffeine in yerba mate.

Read the full interaction Moderate Likelihood Possible Dill + Metformin, Sitagliptini

Theoretically, dill extract might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Ellagic Acid + Metformin, Sitagliptini

Some clinical research shows that ellagic acid reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are on stable doses of hypog...

Read the full interaction Moderate Likelihood Possible Eleuthero + Metformin, Sitagliptini

Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.

Read the full interaction Minor Likelihood Possible Vitamin B12 + Metformin, Sitagliptini

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals.

Read the full interaction
The complete list

Every Supplement Checked Against Metformin, Sitagliptin

All 1,452 ingredients in our database, ranked by severity — 257 with a Metformin, Sitagliptin interaction on file and 1,195 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Metformin, Sitagliptin?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Clove with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.

Full Clove + Metformin, Sitagliptin answer

Can you take Yerba Mate with Metformin, Sitagliptin?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, metformin might increase the levels and adverse effects of the caffeine in yerba mate.

Full Yerba Mate + Metformin, Sitagliptin answer

Can you take Dill with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, dill extract might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Full Dill + Metformin, Sitagliptin answer

Can you take Ellagic Acid with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some clinical research shows that ellagic acid reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are on s...

Full Ellagic Acid + Metformin, Sitagliptin answer

Can you take Eleuthero with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, eleuthero might have additive effects when used with antidiabetes drugs.

Full Eleuthero + Metformin, Sitagliptin answer

Can you take Cashew with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Eating a diet that consists of high amounts of cashew might increase fasting blood glucose levels.

Full Cashew + Metformin, Sitagliptin answer

Can you take Cassia Auriculata with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Cassia auriculata may reduce blood glucose levels and might have additive effects on glucose levels when used with antidiabet...

Full Cassia Auriculata + Metformin, Sitagliptin answer

Can you take Cassia Cinnamon with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.

Full Cassia Cinnamon + Metformin, Sitagliptin answer

Can you take Ceylon Cinnamon with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.

Full Ceylon Cinnamon + Metformin, Sitagliptin answer

Can you take Ceylon Leadwort with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ceylon leadwort root extract has been shown to both increase and decrease blood glucose levels in animal research.

Full Ceylon Leadwort + Metformin, Sitagliptin answer

Can you take Chaga with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chaga with antidiabetes drugs might increase the risk of hypoglycemia.

Full Chaga + Metformin, Sitagliptin answer

Can you take Chicory with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chicory + Metformin, Sitagliptin answer

Can you take Chinese Cucumber with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Chinese cucumber with antidiabetic drugs may have additive effects and adverse effects.

Full Chinese Cucumber + Metformin, Sitagliptin answer

Can you take Chinese Mallow with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with Chinese mallow might increase the risk for hypoglycemia.

Full Chinese Mallow + Metformin, Sitagliptin answer

Can you take Chirata with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Full Chirata + Metformin, Sitagliptin answer

Can you take Chokeberry with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chokeberry might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chokeberry + Metformin, Sitagliptin answer

Can you take Chromium with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.

Full Chromium + Metformin, Sitagliptin answer

Can you take Cissus Quadrangularis with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cissus Quadrangularis + Metformin, Sitagliptin answer

Can you take Coca with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coca might reduce the effects of antidiabetes drugs.

Full Coca + Metformin, Sitagliptin answer

Can you take Cod Liver Oil with Metformin, Sitagliptin?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking cod liver oil with antidiabetes drugs might increase the risk of hypoglycemia.

Full Cod Liver Oil + Metformin, Sitagliptin answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Metformin, Sitagliptin is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Metformin, Sitagliptin, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Metformin, Sitagliptin sits in 5 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Metformin, Sitagliptin through this category.

Metformin (Glucophage) 18 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

18 of the supplement ingredients on this page reach Metformin, Sitagliptin through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Metformin, Sitagliptin through this category.

Organic Cation Transporter 2 (Oct2) Substrates 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Metformin, Sitagliptin through this category.

Sitagliptin (Januvia) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Metformin, Sitagliptin through this category.

Related: does Metformin, Sitagliptin deplete any nutrients?

Metformin, Sitagliptin has 8 reported nutrient associations in the research literature — see the Metformin, Sitagliptin nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Metformin, Sitagliptin

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Metformin, Sitagliptin.

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Pharmacist Counseling Corner

Metformin, Sitagliptin & Supplements: Common Questions

What supplements interact with Metformin, Sitagliptin?
Our database currently documents 257 ingredients with a known Metformin, Sitagliptin interaction (2 major, 217 moderate, 38 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 257. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Metformin, Sitagliptin supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Metformin, Sitagliptin?
Plenty of supplements coexist fine with Metformin, Sitagliptin; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Janumet have the same supplement interactions as Metformin, Sitagliptin?
Yes — Janumet, Janumet XR all contain Metformin, Sitagliptin, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Metformin, Sitagliptin deplete any vitamins or nutrients?
It might — Metformin, Sitagliptin has 8 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Metformin, Sitagliptin nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Metformin, Sitagliptin and my other medications?
This page covers Metformin, Sitagliptin against supplements and herbal ingredients. Checking Metformin, Sitagliptin against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.